Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"genomic heterogeneity"”.
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Unsupervised Signal Deconvolution for Multiscale Characterization of Tissue Heterogeneity
… and subpopulation proportions. Tissue heterogeneity, arising from multiple cell types, is a major confounding factor in studying individual subpopulations and repopulation dynamics. Tissue heterogeneity cannot be resolved directly by most global molecular and genomic profiling methods. …
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Clinical Applications of Genomic Analyses in Prostate Cancer
… by significant intra- and inter-patient genomic heterogeneity. This heterogeneity manifests as variable disease presentations ranging from indolent cancers for which no treatment is needed to aggressive disease that impacts quality of life and survival. Additional biomarkers that predict …
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Characterising the evolutionary dynamics of hypermutated tumours using single-cell sequencing
… dynamics and patterns of intra-tumour heterogeneity, it is paramount to elucidate the clonal dynamics of MMRD tumours. Moreover, genomics analyses of MMRD tumour evolution have relied on bulk whole-genome sequencing (WGS), which is limited to infer the clonal structure and dynamics of …
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Functional Drivers of Therapeutic Response in Diffuse Large B Cell Lymphoma
… a remarkable amount of genetic and clinical heterogeneity, hampering efforts at designing effective therapeutic agents. The last major change in frontline therapy for DLBCL came in 1997 with the addition of rituximab into widespread clinical use. Much effort has been put forth to identify new …
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Molecular Marker Applications in Oat (Avena Sativa L.) Breeding and Germplasm Diagnostics
… Both KASP™ and GBS detected different extents of heterogeneity among a set of 160 seeds that originated from four seed sources of four cultivars. In both cases, the detected variation did not appear to be limited to a specific cultivar or seed source, reinforcing that all cultivars are …
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EPIDEMIOLOGIA GENOMICA DELLE PRINCIPALI VARIANTI DI SARS-COV-2 CIRCOLANTI IN ITALIA PRIMA E DURANTE L'ERA OMICRON
GENOMIC EPIDEMIOLOGY OF THE MAIN VARIANTS OF SARS-CoV-2 CIRCULATING IN ITALY BEFORE AND DURING THE OMICRON ERA Introduction Since the beginning of the pandemic, SARS-CoV-2 has shown a great genomic variability, resulting in the continuous emergence of new variants that has made their global …