Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"genomic damage"”.
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Cas9-induced on-target genomic damage
… an assay for quantification of Cas9-induced genomic lesions that are not small indels ("complex lesions") and used this assay to isolate and genotype complex lesions, many of which would be missed by standard methods. I found that DNA breaks introduced by single guide RNAs frequently resolved …
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Understanding The Mechanism of Genomic Instability During Replicative Aging In Budding Yeast
… most important hallmarks of aging is increased genomic instability. However, there remains much ambiguity as to the cause. I am studying the replicative life span (RLS) of the genetically tractable model organism Saccharomyces cerevisiae, or budding yeast using the innovative “mother enrichment …
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Interaction of amphiphilic gold nanoparticles with lipid membranes and their application to cancer radiotherapy
… radiosensitization causing membrane rupture and genomic damage.
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UV light inactivation of adenovirus, coxsackievirus and murine norovirus
… the inactivation of microorganisms by inducing genomic damage. However the results obtained in this research suggest that different wavelengths emitted by the medium-pressure UV source may be affecting not only the genome of the virus, but also proteins in the viral capsid that may disturb the …
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Effect of space conditions on neuronal plasticity and connectivity
… are known to induce oxidative stress as well as genomic damages. In this thesis, we studied concomitant microgravity and radiation exposures as models for space conditions and developed various methods to analyse their specific and combined effects on in vitro neuronal network models. In vitro …
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Mechanisms of apoptosis modulation and their contribution to genomic instability in tumor cells
… such as DNA repair and assessment of DNA damage (check points). Thus, failure in any of these steps can cause a defective apoptotic response that plays a decisive role in both tumorigenesis and drug resistance in tumor treatment. More distinctly, the capability of cancer cells to go into …
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Age-related genetic and epigenetic chromosomal changes: A twin study
… micronuclei frequencies, which are indicative of genomic damage, significantly increased with age (p<0.0001, r=0.446). The majority of micronuclei (32%) contained sex chromosomes and the frequency of sex chromosome-bearing micronuclei significantly increased with age (p<0.0001). The frequency of …
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Disruption of Dna Polymerase Zeta Promotes An Innate Immune Response
… that protects cells from the consequences of DNA damage and stress. Without pol ζ function mammalian cells and yeast are exquisitely sensitive to genotoxic stresses including ultraviolet irradiation and platinum compounds such as the chemotherapeutic agent cisplatin. This elevated sensitivity …
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Factors That Influence Mammalian Enteric Virus Infection
… assist plaque formation in situations with high genomic damage. This work contributes to mechanisms that influence co-infection of RNA viruses and potentially drive viral evolution. Infection by members of the Picornaviridae family can cause respiratory, cardiac, gastrointestinal, and …
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Untersuchung des genetischen Schadens in peripheren Lymphozyten von Dialysepatienten mittels Mikrokerntest und Comet-Assay
Die vorliegende Arbeit beschäftigt sich im Gegensatz zu bisherigen Studien (überwiegend im Rahmen von Querschnittsstudien) v.a. prospektiv mit der Untersuchung der Auswirkung verschiedener Faktoren (1. Prädialysephase, 2. Wechsel von der Hämodialyse zu HDF-Behandlung, 3. Einfluß einer Angiotensin …