Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 142 for “"genomic analysis"”.
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Genomic analysis of mouse tumorigenesis
… in analyzing mouse models of human cancer using genomic techniques. Comparative genomic studies on mouse and human tumors can be valuable in two major ways: in validating mouse models and in identifying genes that are common to mouse and human tumorigenesis. Many analytic tools have emerged in …
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Genomic analysis of hepatic insulin resistance
Type II Diabetes mellitus is a genetically complex disease characterized by insulin resistance in peripheral tissues, which results in simultaneous hyperglycemia and hyperinsulinemia. Because of the prevalence of type II diabetes, many researchers are investigating the genetics of glucose …
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Genomic analysis of control of cell type
… for high-resolution genome-wide location analysis and gene expression profiling has allowed characterization of the transcriptional regulatory circuitry of cells in unprecedented detail. From this research emerges an improved understanding of how these cells work, how they malfunction in …
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Genomic analysis of cohesin dynamics in fission yeast
… different model organisms. In this thesis, analysis of the cohesin binding pattern reveals that several determinants, thought specific for distinct organisms, collectively define the overall distribution of cohesin along fission yeast chromosomes. Like in budding yeast, cohesin is mainly …
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Genomic analysis of Saccharum species and interspecific hybrids
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Isolation and Genomic Analysis of the Cetacean Y-chromosome
The male-specific mammalian Y-chromosome represents a powerful tool for studying malemediated gene flow and genome evolution. Here it was possible to identify 7 polymorphic microsatellites for the first time in an odontocete species, using a combination of cell culture, cytogenetics and molecular …
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Integrative genomic analysis of Neurogenin2 reprogramming of human iPSCs
… hallmarks, I designed a time course-based genomic analysis that investigated the transcriptional and chromatin accessibility states of cells undergoing NGN2 reprogramming. Bulk RNA and ATAC-sequencing were performed at Day 0, 6h, 12h, Day 1, 36h, Day 2, Day 3, Day 4, Day 14 and Day 21 …
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Genomic analysis of sex chromosomes and sex differentiation in Caricaceae
… The first approach included a transcriptome analysis of papaya flower buds from different sex types at different developmental stages, including the transcriptome analysis of hermaphrodite-to-female sex reversal mutants. The analysis of differentially expressed genes between male, female, and …
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Functional genomic analysis of PPAR-gamma in human colorectal cancer cells
… elucidating the activated PPAR-gamma controlled genomic program responsible for these observed phenotypes, functional genomic analysis was performed using a two-class longitudinal microarray data set in the presence and absence of RS5444. Differential expression of genes was obtained using an …
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Genomic analysis in human solid tumours:Copper Homeostasis Genes in Colorectal cancer
… genes (CHGs) in colorectal cancer, and such analysis, performed on 228 colorectal tumor samples, has revealed that inactivating mutations are extremely rare in CHGs. 2. The collection of whole transcriptome profiles by oligonucleotide microarrays represents the second aim of the thesis. CHGs …
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Integrative statistical methods for the genomic analysis of immune-mediated disease
Genome-wide association studies (GWAS) have proved to be a successful method in cataloguing loci influencing thousands of complex human disease phenotypes. However, elucidating the causal mechanisms underlying such associations has proved challenging due to the regulatory nature of the majority of …
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The development of tools to allow genetic and genomic analysis of Frankia
… interested in developing tools for the genetic analysis of Frankia physiology and its interactions with its host plants. Our approach has focused on the development of a physical and genetic map of the Frankia chromosome by macrorestriction analysis. Agarose-embedded chromosomal DNA plugs were …
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Functional genomic analysis of cell cycle progression in human tissue culture cells
… endoribonuclease-prepared siRNAs (esiRNAs). The analysis of the silencing efficiency and specificity of esiRNAs and siRNAs revealed that esiRNAs are as efficient for mRNA degradation as chemically synthesized siRNA designed with state-of-the-art design algorithms, while exhibiting a markedly …
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Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells
… either HDACi sensitivity or resistance. Genomic comparisons between the sensitive and resistant classes using two independent microarray platforms identified RNH1, encoding a ribonuclease inhibitor, as a gene highly expressed in HDACi-resistant lines. Using genetic knockdown and …
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Functional Genomic Analysis of Natural Product Biosynthesis and Secretion in Aspergillus fumigatus
… confirmed by Southern blot and qRT-PCR analysis. A. fumigatus �akuB:�pes1 was significantly more sensitive to oxidative stress than wild-type (P < 0.01). It was found that, in vitro, either pes1 or sidD significantly improved fungal tolerance to anti-fungal drugs (amphotericin B and …
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Genomic Analysis of Human Spinal Deformity and Characterization of a Zebrafish Disease Model
… we performed copy number variation analysis on 143 patients with isolated scoliosis using the Affymetrix Genome-wide Human SNP Array 6.0. We identified a duplication of chromosome 1q21.1 in 2.1% (N=3/143) of AIS patients, which was enriched compared to 0.09% (N=1/1079) of controls …
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Genetic parameters and genomic analysis of semen quality and fertility traits in pigs
… semen traits and within-boar variation allow an analysis of whether these traits should be included in the breeding goal. Besides the estimation of genetic parameters for selection purposes, the interest in studying the molecular processes and genetic mechanisms affecting semen traits is …
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A genomic analysis of the insect pest populations of cowpea in West Africa
… pest management (IPM) and the current trends in genomic sequencing to cowpea IPM in West Africa with the aim of better understanding the insect pest populations of the cowpea crop and defining their population structure and movement patterns. Chapter 1 which serves as the introduction to the …
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