Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3288 for “"genomic"”.
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Genomic and Non-Genomic Actions of Estrogen Receptor Ligands
… ca. 10,000-fold less potent than estradiol in genomic actions. In contrast to estradiol, EDC was not effective in stimulating breast cancer cell proliferation. Because these EDC ligands activate non-genomic activity at concentrations at which they do not alter the transcription of estrogen …
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Genomic diversity and genomic typing of Salmonella enterica serovar Typhimurium
Salmonella enterica serovar Typhimurium (S. Typhimurium) is one of the most frequently reported serovars in Australia. In the first study of this thesis, 21 S. Typhimurium genomes from Salmonella reference collection A (SARA) were sequenced. Together with 47 publicly available S. Typhimurium …
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Taxonomic classification of genomic sequences : from whole genomes to environmental genomic fragments
… develop a classifier for assigning environmental genomic fragments to the closest known source organism. This has been achieved by the development of a novel method for the TAxonomic COmposition Analysis - TACOA - of environmental genomic fragments using a kernelized nearest neighbor approach. A …
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Wastewater-Based Genomic Epidemiology
… successive waves of infection and reinfection. Genomic surveillance has become a cornerstone of pathogen monitoring, but clinical sequencing remains expensive, logistically demanding and biased by non-random testing. Wastewater–based epidemiology (WBE), whose origins trace back almost a century, …
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High-throughput genomic phenotyping
In the wake of the development of technology to sequence the complete genome of an organism, it has become expedient to generate methodologies to elucidate and characterize the function of all genes constituting the complete genetic makeup of an organism, whereby the knowledge of the genetic code …
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A fast genomic dictionary
Thesis (S.B. and M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.
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Graph-based genomic signatures
… to regions of conserved or divergent gene order. Genomic signatures work by capturing one or more such features efficiently into a compact mathematical structure. This work examines the unique manner in which oligonucleotides fit together to comprise a genome, within a graph-theoretic setting. A …
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Genomic Cis-Regulatory Map Mining.
Genomic Cis-Regulatory Map Mining.
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Risk prediction with genomic data
… is the use of insertions and deletions in the genomic sequence (INDEL) together with SNPs as a feature for prediction. A substantial improvement in the prediction accuracy is achieved using the latter approach. The success of the approach of using NSG data shows that it contains valuable …
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Genomic Evolution in the Oomycetes
… have generated large amounts of oomycete genomic data. Availability of which facilitated bioinformatic characterisation of the secretomes of diverse oomycete species. Using comparative genomic, network, and phylogenetic methods, this thesis reports the identification of lineage and …
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GENOMIC DIVERSITY IN Staphylococcus Aureus
… gel electrophoresis (PFGE). Thirty-nine distinct genomic macrorestriction patterns (GPs) were identified using <em>Sma</em>I; 29 of these patterns are from methicillin-resistant <em>S. aureus</em> (MRSA).</p> <p>A dendrogram showing percent similarity among the patterns was constructed which …
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Genomic diversity of Lactobacillus salivarius
… to have an understanding of the level of genomic diversity present in this species. Comparative genomic hybridization (CGH) and multilocus sequence typing (MLST) were employed to assess the level of genomic diversity in L. salivarius. The wellcharacterised probiotic strains L. salivarius …
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Topics in Genomic Signal Processing
Genomic information is digital in its nature and admits mathematical modeling in order to gain biological knowledge. This dissertation focuses on the development and application of detection and estimation theories for solving problems in genomics by describing biological problems in mathematical …
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Genomic investigation of primary immunodeficiency
Primary immunodeficiencies (PIDs) are a collection of rare diseases which effect one or more components of the human immune system and are typically considered monogenic. PID presents with features including increased susceptibility to infection, autoimmunity, autoinflammation, atopy and …
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Studies on Genomic G-Quadruplexes
… lengths of the three loops formed by potential genomic quadruplexes show strong correlations, and these may be explained in terms of the folding pattern of the quadruplexes. This provides the first evidence of wide-scale presence of actual quadruplexes in the genome, and allows the calculation …
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Genomic analysis of mouse tumorigenesis
… in analyzing mouse models of human cancer using genomic techniques. Comparative genomic studies on mouse and human tumors can be valuable in two major ways: in validating mouse models and in identifying genes that are common to mouse and human tumorigenesis. Many analytic tools have emerged in …
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Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
Nandrolone and other anabolic androgenic steroids (AAS) at elevated concentration can alter the expression and function of neurotransmitter systems and contribute to neuronal cell death. This effect can explain the behavioural changes, drug dependence and neuro degeneration observed in steroid …
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Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes.
… major route towards this prominent intra-tumour genomic diversity in aneuploid neuroblastomas. Taken together, these studies suggest that neuroblastoma genomes are highly plastic, which may to some extent explain the poor response to oncological treatment for some of these tumours.
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Genomic Approaches to Congenital Genitourinary Disorders
… this research was to use both array-comparative genomic hybridization and whole exome sequencing to identify causative variants and candidate genes for PBS, persistent cloaca, and DSD. Sequencing the exomes of two PBS brothers identified a missense mutation in Filamin A and functional testing …
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