Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"genome-wide scan"”.
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Identifikation und Charakterisierung von Suszeptibilitätsloci für Adipositas und Hypercholesterinämie in der NZO-Maus
… syndrome, suggesting a common pathophysiology. A genome wide scan revealed a susceptibility locus for obesity and hyperinsulinemia (Nob1) on mouse chromosome 5 in the vicinity of the markers D5Mit392 and D5Mit302. Nob1 contributed to higher body weight and insulin resistance (LOD-score for BMI > …
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Computational methods for the analysis of next generation sequencing data
… extended the ability to study the human genome and to better understand the biology of genomes, the new technology has required profound changes to the data analysis. There is a substantial need for computational methods that allow a convenient analysis of these overwhelmingly …
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Identifizierung und Charakterisierung von Suszeptibilitätsloci für Typ-2-Diabetes mellitus in einem Mausmodell für das Metabolische Syndrom
… glucose, serum insulin, serum lipids). In a genome wide scan with more than 100 polymorphic microsatellite markers, a significant susceptibility locus (Nidd/SJL, LOD score >8) for hyperglycemia with hypoinsulinemia was identified on the distal end of chromosome 4. This SJL-derived locus was …
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Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
… adherence to gluten-free diet (GFD). In a Scandinavian genome wide scan, performed by our group and published in 2001, eight chromosomal regions apart from HLA showed nominal significance (p < 0,05), among them 5q31-33. This region was previously suggested as a susceptibility region in …
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Clinical and genetical aspects of Celiac Disease
… ered all fi rst-degree relatives of CD patients. Genome-wide linkage scan was performed in the same material. Th is work showed signifi cant evidence of linkage to CD with an interesting region on chromosome 5q31-33 and on chromosome 11q. Simplex CD family material was collected for further …