Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"genome-wide profiling"”.
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Genome-Wide Profiling Unveils Criticial Functions of P53 In Human Embryonic Stem Cells
… for p53 function. Surprisingly, although p53 is widely recognized as the guardian of the genome, due to its roles in cell cycle checkpoints, programmed cell death or senescence, relatively little is known about p53 functions in normal cells, especially in ESCs. My <strong>hypothesis </strong>is …
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DISCOVERY OF NOVEL EPIGENETIC MECHANISMS OF CARCINOGENESIS BY GENOME-WIDE PROFILING OF NON-CODING REGULATORY ELEMENTS
… marks to study important regions of the cancer genome that are key regulators of transcription with unprecedented resolution and accuracy. In this work, in-depth studies of epigenetic features of both promoters and distal enhancer elements are described, in each case enabled by distinct histone …
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Decoding Brain Somatic Mosaicism with New Single-Cell Copy Number Analysis Methods
… aging and disease. While single-cell whole-genome sequencing (scWGS) enables genome-wide profiling at single-cell resolution, existing computational methods struggle to accurately detect non-clonal CNVs, limiting our understanding of genomic mosaicism in the brain. In this thesis, I present …
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A multidisciplinary investigation into the function of NFXL1
… survival, lifespan, and larval locomotion. Genome-wide profiling using an existing ChIP-seq dataset in embryos and NanoDam in larval glial cells identified CG15011-binding sites enriched for cytoskeletal organisation and neuronal projection morphogenesis. Weighted gene co-expression network …
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Define The Epigenetic Profiles and Subtype-Specific Genes of Breast Cancer
<p>Molecular profiling has identified 5 distinct subtypes of breast cancer, luminal A, luminal B, HER2-enriched, basal-like, and claudin-low breast cancer. These 5 subtypes correlate with hormone response, patient prognosis, and response to therapy. Although steady state gene expression patterns …
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BIOLOGICAL AND MOLECULAR CHARACTERIZATION OF CMA-03/06, A NEWLY ESTABLISHED INTERLEUKIN-6 INDEPENDENT VARIANT OF THE CMA-03 HUMAN MYELOMA CELL LINE.
… using a high sensitivity IL-6 specific ELISA. Genome-wide profiling data were generated by means of Affymetrix GeneChip Human Mapping 250K NspI arrays; copy number (CN) alterations were calculated using the DNAcopy Bioconductor package, based on circular binary segmentation method. Global gene …
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Integrative Analysis of Omics Data In Adult Glioma and Other Tcga Cancers to Guide Precision Medicine
<p>Transcriptomic profiling and gene expression signatures have been widely applied as effective approaches for enhancing the molecular classification, diagnosis, prognosis or prediction of therapeutic response towards personalized therapy for cancer patients. Thanks to modern genome-wide profiling …
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P53 Maintains Hepatic Cell Identity During Liver Regeneration
… analyses (microarray and RNA sequencing) and profiling of p53 interactions with chromatin (ChIP sequencing) at the G1-S transition of normal cell cycle, corresponding to 24h post-PH in mice liver regeneration, will reveal p53 functions during cell cycle regulation in normal cells and during …
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Signal Transduction in Skeletal Muscle Mediating Responses to Phenotype Altering Signals
… at 10 ng ml 4 to C2C12 cells, and using cDNA genome-wide profiling, was shown to act as a transcriptional suppressor. Furthermore, in these cells myostatin significantly (n8, p<0.05) reduced phosphorylation of components in the P1-3K pathway: PKB Ser473 -30 %, mTOR Ser2448 -50 %, p70 S6K …