Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"genome-wide association analysis"”.
-
Genome-Wide Association Analysis of Major Depressive Disorder and Its Related Phenotypes.
… that ranks fourth as cause of disability worldwide. Thirteen to 14 million adults in the U.S. are believed to have MDD and an estimated 75% attempt suicide making MDD a major public health problem. Recently several genome-wide association (GWA) studies of MDD have been reported; however, few …
-
Molecular characterization of ovine GM1 gangliosidosis
… and ten unaffected animals were genotyped and a genome wide association analysis was performed using PLINK. A significant association was detected for multiple SNPs on OAR19; further investigation showed this area was orthologous to HSA3 containing GLB1. Sequence analysis revealed a G to T …
-
The evolution and genetics of virus resistance in Drosophila
… pipeline, I recovered partial viral genomes which were used to reconstructed their phylogeny. Then, I experimentally explored the impact of the newly isolated viruses on Drosophila infected with Wolbachia, a mutualistic endosymbiotic bacterium that protects the flies against RNA …
-
Dissection of Soil Waterlogging Tolerance in Soft Red Winter Wheat using Genomic Approaches
<p>Genomic methods including genome wide association analysis (GWAS), genomic selection (GS) and RNA-seq allow for faster selection of superior breeding lines and for identification and resolution of candidate genes. A panel of 240 soft red winter wheat (Triticum aestivum L.) cultivars and breeding …
-
Investigation into the causal effect of iron metabolism on cardiovascular disease
… despite 30 years of research into this suggested association, there is still no consensus regarding the causal effect of iron on CVD. Objectives: To establish the likelihood of a causal effect of iron metabolism on risk of coronary heart disease (CHD) and stroke using five markers of iron …
-
Genetic control and prediction of milling and baking quality for UK wheat breeding
… wheat quality and micronutrient traits. This analysis identified multiple quantitative trait loci (QTL) with co-locating pleiotropic effects that could explain much of the complementary and antagonistic relationships among these traits. Of note, a QTL that co-located with the awn length …
-
Genome-wide association study of muscle traits in Icelandic sheep
… allra gripa. Erfðamengis-tengslagreining (e. genome-wide association study) var framkvæmd annars vegar með BLUP einkunn sem eiginleika og hins vegar með öll sýnin skipt í tvo hópa; valið vöðvafé og óvalið fé sem tilfelli og viðmið (e. case/control). Fáir einbasabreytileikar voru tölfræðilega …
-
Mapping phenotypic traits in swine
… to detect QTL in this population. For the first analysis, a linkage map consisting of 137 microsatellite markers was used to perform a regression interval analysis with QTLexpress, a publicly available web-based software. In the second analysis, the SOLAR software package was used to perform a …
-
Characterization of arbuscular mycorrhial fungi on Glycine max and its influence on plant disease severity
… arbuscular mycorrhizal fungi (AMF) that form associations with over 80% of all terrestrial plant species and assist plants by increasing nutrient uptake, drought tolerance, and resilience against pathogens and pests. However, the level of benefit may be variable and be host-genotype dependent. …
-
Associated behavioral, genetic, and gene expression variation with alternative life history tactics in salmonid fishes
… and 3) using genetic polymorphisms to test for associations with ecotype, as well as population structure, in polymorphic populations. First, we evaluated the variation in a suite of ecologically relevant behaviors across time in juvenile progeny produced from crosses within and between …
-
Genomics of sickle cell disease and fetal hemoglobin in African populations
… in African Americans and non-anemic Europeans. Genome-wide association studies have been employed to replicate two of the three major loci (BCL11A and HBS1L-MYB) in African SCA patients, as well as to identify new loci including BACH2 involving a meta-analysis of African Americans and …