Global ETD Search
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Showing 1 to 20 of 403 for “"genome-wide association"”.
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Genome-wide association study of persistent developmental stuttering
A genome-wide association study (GWAS) is an approach that involves scanning markers across complete sets of DNA, or genomes, of many people to indentify genetic variations associated with a particular disease. A GWAS uses unrelated individuals, and for the purposes of this study, only those who …
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Assessment of Penalized Regression for Genome-wide Association Studies
The data from genome-wide association studies (GWAS) in humans are still predominantly analyzed using single marker association methods. As an alternative to Single Marker Analysis (SMA), all or subsets of markers can be tested simultaneously. This approach requires a form of Penalized Regression …
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Genome-wide association study for sperm motility in pigs
A qualidade do sêmen de reprodutores suínos pode ser avaliada de acordo com vários critérios, sendo a motilidade espermática o mais utilizado e importante. A motilidade, essencial para a fertilização, refere-se ao movimento retilíneo dos espermatozóides. Apesar da importância da avaliação de …
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Leveraging the microbiome in host genome wide association studies
Genome-wide association study (GWAS) has emerged as an effective method for detecting genetic polymorphisms associated with expressed phenotypes. Over the past decade, GWAS of human traits and diseases has revolutionized the field of complex disease genetics, identifying hundreds of genetic …
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Genome-wide association study of muscle traits in Icelandic sheep
… allra gripa. Erfðamengis-tengslagreining (e. genome-wide association study) var framkvæmd annars vegar með BLUP einkunn sem eiginleika og hins vegar með öll sýnin skipt í tvo hópa; valið vöðvafé og óvalið fé sem tilfelli og viðmið (e. case/control). Fáir einbasabreytileikar voru tölfræðilega …
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Phenotype prediction and feature selection in genome-wide association studies
Genome wide association studies (GWAS) search for correlations between single nucleotide polymorphisms (SNPs) in a subject genome and an observed phenotype. GWAS can be used to generate models for predicting phenotype based on genotype, as well as aiding in identification of specific genes …
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Computational Contributions Towards Scalable and Efficient Genome-wide Association Methodology
Genome-wide association studies are experiments designed to find the genetic bases of physical traits: for example, markers correlated with disease status by comparing the DNA of healthy individuals to the DNA of affecteds. Over the past two decades, an exponential increase in the resolution of …
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Towards constructing disease relationship networks using genome-wide association studies
Background: Genome-wide association studies (GWAS) prove to be a powerful approach to identify the genetic basis of various human[1] diseases. Here we take advantage of existing GWAS data and attempt to build a framework to understand the complex relationships among diseases. Specifically, we …
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Functional Genome Wide Association Study in Susceptibility and Resistance of Malaria
… qualified as a mortal infectious disease, worldwide causing high morbidity and mortality. The World Health Organization (WHO) has shown that, Distribution of Malaria in Africa takes a major part, it's accounting for 95% (about 229 million) and 67% (about 274000) of reported cases and death …
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A comparative analysis of machine learning algorithms for genome wide association studies
Variations present in human genome play a vital role in the emergence of genetic disorders and abnormal traits. Single Nucleotide Polymorphism (SNP) is considered as the most common source of genetic variations. Genome Wide Association Studies (GWAS) probe these variations present in human …
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Genome-Wide Association Analysis of Major Depressive Disorder and Its Related Phenotypes.
… that ranks fourth as cause of disability worldwide. Thirteen to 14 million adults in the U.S. are believed to have MDD and an estimated 75% attempt suicide making MDD a major public health problem. Recently several genome-wide association (GWA) studies of MDD have been reported; however, few …
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Characterizing non-coding hits in genome-wide association studies using epigenetic data
… putting it within reach. In the last ten years, genome-wide association studies have identified thousands of genetic variants associated with disease. However, the majority of these variants fall outside genes making interpreting their role in disease difficult. In parallel, the ENCODE and …
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A GPU program to compute SNP-SNP interactions in genome-wide association studies
… technologies, short read sequences of human genome are made more accessible. Paired end sequencing of short reads is currently the most sensitive method for detecting somatic mutations that arise during tumor development. In this study, a novel approach to optimize the detection of structural …
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Genetics of Eating Disorders: a candidate gene and a genome-wide association approach
… females), and Chapter 4 presents the results of genome-wide association gene (GWAG) analyses of these traits. No gene p values passed a multiple gene testing correction, but among the top genes were several previously implicated in the aetiology of eating disorders. Larger sample sizes would be …
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A Genome-Wide Association Study on Widespread Pain using the UK Biobank Cohort
… to explore the genetic variants associated with widespread pain in a cohort of UK Biobank participants who had completed a pain phenotyping questionnaire.<br/><br/><b>Method</b>: Cases and controls were determined by a question answered by UK Biobank participants. The question contained 10 …
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Genome-wide association study of Pseudomonas aeruginosa adaptations to the cystic fibrosis lung
… of some of the changes that occur. I performed a genome-wide association study inP. aeruginosausing a variety of analysis methods and several datasets of gene and SNP presence/absence. I determined that the machine learning algorithms random forest and support vector machines performed well on …
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Genome-wide association mapping of temperature response in agronomically important traits of soybean
… and plant development under temperature stress. Genome-wide association study (GWAS) using high-density and high-quality single nucleotide polymorphisms (SNPs) is a powerful tool to associate markers and important traits. The aims of this study are: 1) to characterize the effects of low and high …
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Repurposing variance genome-wide association studies (vGWAS) for identifying gene-by-environment interactions
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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Network-based approach for post genome-wide association study analysis in admixed populations
In this project, we review some existing pathway-based approaches for GWA study analyses, by exploring different implemented methods for combining effects of multiple modest genetic variants at gene and pathway levels. We then propose a graph-based method, ancGWAS, that incorporates the signal from …
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