Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"genome-wide SNP"”.
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Molecular genetic characterization of ataxic movement disorders in mouse and human
… Purkinje cells. In addition, high density genome wide SNP genotype data in humans showed a SUMF1-ITPR1 deletion to segregate with spinocerebellar ataxia 15 (SCA15), a late-onset autosomal dominant disorder, which was previously mapped to the genomic region containing ITPR1; however, no …
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Imputation of Microsatellite Markers With Tag SNPs
… common forms of genetic variation in the human genome, Single Nucleotide Polymorphisms (SNPs) and Variable Number Tandem Repeat Polymorphisms (VNTRs), SNPs are much more easily and inexpensively assayed in a high-throughput manner. For this reason, we seek to explore methods that can allow us to …
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The Genetics of General Cognitive Ability
… Research (MCTFR). Study #1 (N = 7,100) is a genome-wide association study plus other analyses that exploit genome-wide single-nucleotide polymorphism (SNP) data. Study #2 (N = 6,439) is an association study of a different class of genetic polymorphism, the copy-number variant (CNV). In this …
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Polygenic association in ADHD for the prediction of cognitive performance
… polygenic signals for ADHD generated from genome-wide SNP data are associated with the most promising cognitive variables. Analysis used data from the International Multi-Centre ADHD Gene (IMAGE) project. Transmission disequilibrium test (TDT) was conducted and the data used to generate …
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The Labrador Retriever as a Model of Naturally Occurring Myopia: Genetic and Environmental Contributions
… genetic loci for canine refractive error using a genome wide SNP array with a myopic case group and a non-myopic control group. Results: A significant prevalence (37%) of myopia was found within the pedigree studied. Familial aggregation analysis demonstrated a significant genetic contribution, as …
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A Genome Wide Association Study for Fusarium Head Blight Resistance in Southern Soft Red Winter Wheat
… and 3) identify novel resistance loci using a genome wide association (GWA) approach. From 2014-2017, 360 SRWW breeding lines were evaluated in inoculated misted FHB nurseries in Fayetteville and Newport, AR and Winnsboro, LA (2017 only) in a randomized complete block design. At all locations, …
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Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
… aetiology of SLE is complex; however, twin and genome-wide association (GWA) studies clearly indicate that SLE has a strong genetic component. Most recently, Copy Number Variations (CNVs) have been shown to be ubiquitously present in unrelated healthy subjects and contribute substantially to …
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Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
… aetiology of SLE is complex; however, twin and genome-wide association (GWA) studies clearly indicate that SLE has a strong genetic component. Most recently, Copy Number Variations (CNVs) have been shown to be ubiquitously present in unrelated healthy subjects and contribute substantially to …
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Diversification of Antbirds Associated with Amazonian Flooded Forest Habitats
… Here I used morphometrics, plumage and genome-wide SNP datasets to uncover clinal patterns in three species of flooded forest antbirds at different stages of divergence. I found weak phylogeographic structure in Hypocnemoides maculicauda and H. melanopogon and much stronger structure in …
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Simultaneous Mapping and Pyramiding of Fusarium Head Blight Resistance Loci in Wheat Breeding Populations
… linkage maps showed high concordance with the SNP consensus map for wheat. This suggests that linkage mapping in early generation plant breeding populations represents a reliable and efficient approach to support molecular breeding efforts. In the second study, we apply identical-by-descent …
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Genetic and morphometric variation of two focal snapper species (Lutjanus bohar and Lutjanus gibbus) in the Chagos Archipelago
… of population structure was carried out using genome wide SNP markers. Weak population structure was detected between all atolls, for both species (Fst 0.001-0.009) indicating good genetic connectivity among lutjanids throughout the Chagos Archipelago. The combined findings of this research are …
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Genetic analysis of Cannabis flowering traits in differential environments
… Population genetic analysis, using a custom genome-wide SNP panel, revealed that the genetic architecture of cannabis inflorescence yield may be population-specific with narrow-sense heritability estimates varying between populations. Furthermore, conducting a genome-wide association study …
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An Assessment of the Relationship among Oxidative Stress, Adaptive Immunity and Genetic Variations in the Chicken, Gallus gallus
… a 2734-bp region of mtDNA, but no definitive SNP was detected. In another experiment, 40 chickens were conversely selected according to three biomarkers for OS. Although no variation was found at eight SNP loci tested across the mitochondrial genome, mtDNA damage measured by …
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The colonisation of canola crops by the diamondback moth, Plutella xylostella L., in southern Australia
… the most destructive pest of Brassica crops worldwide, seasonally colonises winter canola crops in southern Australia leading to intermittent outbreaks. Little is known about regional movement and crop colonisation patterns of P. xylostella in the Australian canola agro-ecosystem, or the …
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Illuminating the Drivers of Genomic Diversification in Lamprologine Cichlids of the Lower Congo River
… infer gene flow rates and flow direction using genome-wide SNP data. Previous studies suggest that numerous high-energy rapids present in the LCR are physical barriers to gene flow, thus facilitating diversification and generating ichthyofaunal diversity. This study suggests high-energy rapids …
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Genetic investigation of recurrent exertional rhabdomyolysis risk and performance in racehorses
… in Standardbred racehorses using high density genome-wide SNP data. Heritability for fastest mile times, fastest last quarter mile times, and career earnings in a large population of North American STDB racehorses was moderately heritable, with the greatest variability in heritability estimates …
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Cryptobenthic Coral Reef Fishes: Resolving Critical Gaps in Species Delimitation, Sampling Techniques, and Phylogenetic relationships
… undetected cryptic species, which may require a genome-wide species delimitation approach to discern how many species are present. One of the most species-rich groups of CRF, the genus Eviota, has 132 species described to date, is widely distributed from the Red Sea to Hawaii and French …