Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"genome-scale modeling"”.
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Investigating Non-model Microorganisms for Biomanufacturing via Systems Biology and Machine Learning
… numerous production strains at the laboratory scale. However, selecting gene engineering targets is non-trivial, as lessons learned from previous microbes are not always applicable. Additionally, promising laboratory strains routinely fail to maintain performance during scale-up, requiring …
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Systems metabolic engineering through application of genome-scale metabolic flux modeling
… in systems metabolic engineering involves genome-scale metabolic flux modeling. These models allow generation of predictions of the global metabolic flux distribution in the metabolic network of organisms, in silico. With the current advances in genome sequencing technologies and the global …
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Multiscale, multiparadigm metabolic modeling of the keystone diazotrophic cyanobacterium, Trichodesmium erythraeum
… require organisms to interact. Current modeling techniques neglect many of these phenomena, considering cells as separate entities, homogeneous populations, or static members of a population. Biological data conflict with these models: organisms are highly dynamic even in the most ideal …
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Total proton flux and balancing in genome-scale models: The case for the updated model of Clostridium acetobutylicum ATCC 824
Genome-scale modeling and new strategies for constraining these models were applied in this research to find new insights into cellular metabolism and identify potential metabolic engineering strategies. A newly updated genome-scale model for Clostridium acetobutylicum, iMM864, was constructed, …