Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 179 for “"genome sequence"”.
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Genome sequence of the hyperinvasive Campylobacter jejuni strains
Campylobacter jejuni is the world’s major cause of gastroenteritis in humans. Although motility, toxin production, adhesion and invasion are some of the key factors associated with C. jejuni pathogenesis, their mechanism in the disease process remains unclear. The key aim of this project is to …
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Development of computational approaches for whole-genome sequence variation and deep phenotyping
… possible to detect variants in 98% of the human genome. A drop in sequencing costs made it feasible to sequence 10,000 individuals including 1,250 subjects diagnosed with PAH and relatives as part of the NIHR Bioresource – Rare (BR-RD) disease study. This large cohort allows the genome-wide …
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Identification of Genetic Copy Number Variants in Neurodevelopmental Disorders from Genome Sequence Data
… to identify CNVs from whole exome or whole genome sequence reads. However, there are no established best practices for CNV detection, and the use in molecular diagnostics is not routine. This thesis aimed to establish a bioinformatic framework for the identification of causative CNVs from …
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Robust and Efficient Algorithms for Protein 3-D Structure Alignment and Genome Sequence Comparison
Sequence analysis and structure analysis are two of the fundamental areas of bioinformatics research. This dissertation discusses, specifically, protein structure related problems including protein structure alignment and query, and genome sequence related problems including haplotype …
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Genome Sequence Analysis and Characterization of Recombinant Enzymes from the Thermoacidophilic Archaeon Picrophilus torridus
Picrophilus torridus ist ein thermo- und acidophiles Archaebacterium, welches mit seinen Wachstumsoptimum bei 60 °C und pH 0,7 den bislang acidophilsten bekannten Organismus repräsentiert. Im Rahmen dieser Arbeit wurde das komplette Genom von P. torridus sequenziert und im Anschluss die …
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Characterisation of the Ugandan HIV epidemic with full-length genome sequence data from 1986 to 2016
Presented here are two large Ugandan HIV genome datasets, one from the modern period (by the MRC/UVRI & LSHTM group and PANGEA), and another generated from stored 1986 serum samples using target-capture next generation sequencing. Uganda uniquely has two HIV subtypes at similar proportions, and …
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Complete Genome Sequence and Pathogenicity of Two Swine Parainfluenzaviruses Isolated from Pigs in the United States
… studies were undertaken. The complete genome of Texas81 virus was 15456 nucleotides (nt) and ISU92 was 15480 nt in length consisting of six non-overlapping genes coding for the nucloeo- (N), phospho- (P), matrix (M, fusion (F), hemagglutinin-neuraminidase (HN) and large polymerase (L) …
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The complete plastid genome sequence of Passiflora cincinnata: genome rearrangements, massive plastid gene losses and implications to genome-plastome incompatibility
The plastid genome (plastome) organization, gene content and order is well conserved in most angiosperms, but there are some exceptions. The Passiflora genus is one of those exceptions, because there are evidences of some unusual plastid gene losses to species of this genus. However, none plastome …
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Characterisation of the function(s) of a novel gene, CLWD
The availability of the human genome sequence has shown that there are many genes of completely unknown function; one of these is C20ORF149, or CLWD. We initially studied this gene because of its proximity to the deletion in wasted mice, but have found that whilst it is not involved in the …
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Complete computational sequence characterization of mobile element variations in the human genome using meta-personal genome data
… have been developed to detect such types of genome sequence variations as single nucleotide polymorphisms (SNPs) and small indels, comparatively fewer methods have been developed for finding structural variants (SVs) and in particular mobile elements insertions (MEIs). Moreover, almost all …
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HUMAN GENOME VARIATIONS AND EVOLUTION WITH A FOCUS ON THE ANALYSIS OF TRANSPOSABLE ELEMENTS
Genome sequence varies in numerous ways among individuals although the gross architecture is fixed for all humans. Retrotransposons create one of the most abundant structural variants in the human genome and are divided in many families, with certain members in some families, e.g., L1, Alu, SVA, …
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Comparative genomics of Bifidobacteria
Chapter 2 of this thesis describes the sequence analysis of 14 bifidobacterial genomes from various species of the genus Bifidobacterium, and the determination of their open pan-genome trend. This analysis first determined the total number of genes to be considered as the reservoir of functions …
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Evolutionary dynamics of the Yersinia enterocolitica complex
… six different biotypes (BT), but only a single genome sequence for high-pathogenic BT 1B was available at the start of the project.
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Application of Single-Molecule Analytical Methods for the Characterization of Multimeric Genetic Elements in Yarrowia lipolytica DSM 3286
… in production cell lines or in potential host genomes is a critical regulatory component in the assessment of potential health risks associated with therapeutic proteins and gene therapeutics. Current methods are based on short-read sequencing and PCR amplification steps, which are limited in …
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Reconstructing Chromothriptic Chromosomes in Oesophageal Adenocarcinomas
… from functional compartmentalisation of genomic sequences into topologically associating domains, to chromosome looping, to short-range promoter-enhancer interactions. The underlying genome sequence contributes to this regulation, likely at a variety of scales, however the extent of this …
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DNA Methylation and Genetic Divergence Associated with an Inducible Defensive Response in Mimulus guttatus
… inherited in a way that is sensitive to genome-wide demethylation when transmitted through the maternal but not the paternal germline. Investigation of this phenomenon has been hampered by a lack of computational tools to analyze pooled methylome and genome sequence data. In this study, …
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Genetic characterization of Rhodococcus rhodochrous ATCC BAA-870 with emphasis on nitrile hydrolysing enzymes
… mine the organism for biotechnological uses, the genome was sequenced using Solexa technology and an Illumina Genome Analyzer. The Solexa sequencing output data was analysed using the Solexa Data Analysis Pipeline and a total of 5,643,967 reads, 36-bp in length, were obtained providing 4,273,289 …
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Pyrimidine Genes in Pseudomonas Species
… and genetic maps of P. aeruginosa PAO1 with the genome sequence. The final section compares pyrimidine gene arrangements in three species of Pseudomonas. Pyrimidine biosynthesis and salvage genes will be aligned for P. aeruginosa PAO1, P. putida KT2440, and P. syringae DC3000. The whole study …
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