Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"genome project"”.
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Genobiography: The Beethoven Genome Project as a case study integrating genomics into historical biography
… enabling the sequencing of high-coverage genomes from small quantities of historical hair. Eight independently sourced locks of hair plausibly attributed to Beethoven underwent genomic analyses. Five of these were found to originate from a single European male with an ancestry profile and …
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Arguing the Genome: A Topology of the Argumentation Behind the Construction of the Human Genome Project
The Human Genome Project (HGP), the name given to the scientific program to map and decode all of human genetic material, has been projected to revolutionize the conduct of biological science in the twenty-first century. For several years before its formation in 1990, a federally-funded, systematic …
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The ELSI Research Program and Genetic Nondiscrimination Legislation: A Study in Science and Public Poilicy
The Human Genome Project, a multi-national initiative to map and sequence the entire human genome, is expected to reach completion in the year 2003. One of the more immediate and direct results of this remarkable scientific effort is an increase in both the number and range of genetic tests …
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Computational verification of published human mutations
The completion of the Human Genome Project, a remarkable feat by any measure, has provided over three billion bases of reference nucleotides for comparative studies. The next, and perhaps more challenging step is to analyse sequence variation and relate this information to important phenotypes. …
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SIGN HERE : informed consent in personalized medicine
… has slowly been approaching. However, the human genome is not enough, not unless we can decipher its language. One ambitious study to this effect is the Personal Genome Project, led by Dr. George Church at Harvard Medical School. This project will eventually recruit 100,000 volunteers to donate …
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PASSS: Protein Active Site Structure Search
The Protein Structure Initiative, a project on the scale of the Human Genome Project aimed at protein structure determination, has successfully identified the structure of multiple human proteins. Unfortunately, knowledge of structure alone provides little insight into a protein's function within …
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Needs Analysis of Genetics and Genomics in Communication Sciences and Its Disorders: Evidence for Change
Purpose: Signaled by the completion of the Human Genome Project in 2003, rapid and escalating discovery in genome science has initiated a paradigm shift in education training and healthcare practices. This shift has required healthcare educators and professionals to possess a level of genetic and …
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The DNA of a high-performing manufacturing organization : improving operations capability through performance measurement
… contains the world's highest-throughput genome sequencing center, which contributed approximately one third of the sequence for the Human Genome Project (HGP) completed in 2003. Broad's Genome Sequencing Operations Group has acquired a cost leadership position within the genome sequencing …
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Computational genomics : mapping, comparison, and annotation of genomes
… we address key issues in the different stages of genome research: planning of a genome sequencing project, obtaining and assembling sequence information, and ultimately study, cross-species comparison, and annotation of finished genomic sequence. We present applications of computational techniques …
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Genetic Sequencing in Healthy Populations
After the success of the Human Genome Project, genetic sequencing technology has improved exponentially. Consumers can now have parts of their genome sequenced for under $100. Genetic sequencing in this direct-to-consumer (DTC) setting comes with many ethical problems that, despite being brought to …
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Graphene supported hafnium oxide nanopores for DNA sensing
The completion of the Human Genome Project in 2001 has served as both an inspiration and a challenge for researchers in the past decade. Understanding the genetic makeup of organisms is crucial for early disease detection, one of the driving forces behind personalized medicine. In this work, …
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Genome sequencing technology : improvement of the electrophoretic sequencing process and analysis of the sequencing tool industry
… system and its data. Due to its use in the human genome project (HGP), ABI has established a monopolistic position in the DNA-sequencing tool industry. As the de-facto standard of DNA sequencers ABI3730xl is highly automated, well-optimized, and black-boxed, despite the importance of higher …
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Owning the code of life : human gene patents in America
… a central role in the early years of the Human Genome Project, and continued as people experienced the challenging consequences of assigning property rights to our shared biology. Several patients with genetic diseases were forced to navigate limited or expensive testing because of a company's …
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Enabling sample tracking in and reducing variability in DNA library construction
… The Institute gained prominence during the Human Genome Project and has continued to be the nation's leading public laboratory for genomic sequencing projects. The Broad Institute has done this by taking advantage of economies of scale, rapid process innovation, and new process implementation. …
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BioInformatics, Phylogenetics, and Aspartate Transcarbamoylase
… against the contiguous sequence from its own genome project. A BLAST (Basic Local Alignment Search Tool; Atschul, et al., 1990) was performed in order to hypothesize the remaining portion of the gene from the contiguous sequence. This allowed a global comparison to other known aspartate …
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Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center
… contains the world's largest high throughput genome sequencing center, which contributed approximately one third of the sequence for the Human Genome Project (HGP) completed in 2003. The Molecular Biology Production Group (MBPG) is the most upstream part of the Broad Institute's genome …
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Innovation in the life sciences : the impact of intellectual property rights on scientific knowledge diffusion, accumulation and utilization
… I take as my research setting, the Human Genome Project (HGP) and our mapping of the entire human genome that emerged from the project (as defined in both scientific publications and patents). The HGP was a 13-year, $3.8 billion research effort funded and coordinated by the U.S. Department …
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Physical Map between Marker 8O7 and 146O17 on the Medicago truncatula Linkage Group 1 that Contains the NIP Gene
… and 23C16D. Based upon data from the Medicago genome sequencing project, a subset of the model legume Medicago truncatula bacterial artificial chromosomes (BACs) were used to create a physical map on the DNA in this genetic internal. BACs near the potential NIP gene location near marker 164N9 …
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Development of tools for automated collection, integration and analysis of genetic data in ALS
… frequency of each variant found in the 1000 Genome Project and Exome Variation Server (EVS) databases is displayed. To contribute to a better understanding of the pathogenesis of ALS, links to information on animal models are also available. Furthermore, ALSoD can now be viewed on mobile …
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Covalent end-immobilization of oligonucleotides onto solid surfaces
With the completion of the Human Genome Project, the focus of genetics research has shifted towards functional genomics, with emphasis on gene expression and polymorphism studies. To this end, there is rapidly increasing interest in solid-phase, high-throughput, combinatorial microarrays for DNA …
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