Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"genome biology"”.
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Co-linear Chaining on Graphs With Cycles
… in bioinformatics. As the volume of sequenced genomes grows rapidly, pairwise sequence alignment becomes inefficient for pan-genomic analyses involving multiple sequences. The graph representation of multiple genomes has been an increasingly useful tool in pan-genomics research. Therefore, …
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Genome-graph based genotyping with applications to highly variable genes in P. falciparum
Analysing genetic variation in pathogen genomes is key to understanding their biology, evolution and epidemiology. Typically, this is done by assembling one arbitrary genome, defined as the ‘reference’, and describing other samples as deviations from it. However, this model breaks down in highly …
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New insights into Transposable Elements from high quality genome sequences across diverse animals
New high quality genomes, together with faster whole genome alignment methods, have opened the possibility of identifying new transposable element (TE) families by their polymorphic character in different haplotypes, in contrast to previous methods based on repetitiveness, homology and structural …
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Investigating the function of DNA G-quadruplex structures in human enhancers
… that form in guanine-rich regions of the genome. G4s are enriched at sites of important regulatory potential in diverse genomes, including promoters and enhancers. Enhancers interact with target promoters through 3D folding of interphase chromosomes to regulate gene transcription. However, …
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Evaluation of Annotation Performances between Automated and Curated Databases of <i>E.COLI</i> Using the Correlation Coefficient
This project compared the performance of the correlation coefficient to show similarities in annotations between a predictive automated bacterial annotation database and the curated EcoCyc database. EcoCyc is a conservative multidimensional annotation system that is exclusively based on …
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Investigating the effects of genetic variation on heterochromatic crossover events in Arabidopsis thaliana
… frequency by natural genetic variation. Genome-wide effects on crossover frequency were evaluated using natural variation and biotic stress. Significant crossover frequency variation was recorded throughout the genome in Col- 0/relict F1 hybrids. A diverse panel of Arabidopsis accessions …