Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"genetics and disease"”.
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Middle ear development: Genetics and disease
… of three bony ossicles, the malleus, incus, and stapes that function to conduct sound from the external to the inner ear. Normal development of middle ear structures is integral for transduction of sound, defects resulting in conductive deafness. Mice are reliant on both embryonic and …
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Decoding CD4+ T cell activation by multi-modal phenotyping
… implicated in the biology of immune-mediated diseases, yet the molecular and functional mechanisms governing this process remain incompletely understood. With the explosion of profiling and functional genomic methods in the last decade, it is now feasible to interrogate the more intricate …
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Nash Alters Drug Metabolizing Enzyme and Transporter Expression Resulting in Significant Consequences for Pharmaceutical Disposition and Toxicity
… must remove in order to prevent damage to cells and organs. This system of removal is a collection of processes known as ADME (absorption, distribution, metabolism, and excretion). The dynamics of ADME ultimately determine the fate, or pharmacokinetics, of a xenobiotic in the body whether it be …
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Conformational engineering of human chemokine receptors and HIV-1 Env using deep mutational scanning
… are made at sites of suspected importance, and the activity of each variant is individually tested. However, by combining directed evolution and deep sequencing with site- saturation mutagenesis (SSM) to create unbiased, diverse libraries, it is now possible to track the phenotypic fitness …