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Showing 1 to 5 of 5 for “"genetically encoded sensor"”.
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Heterogeneity in the population response of a human cell line to hydrogen peroxide as measured by a genetically encoded sensor
Genetically encoded ratiometric sensors can provide valuable mechanistic understanding of biological systems. Characterization of cellular response of these sensors is the first step in validating their use. Here, we characterize the response of a genetically encoded H₂O₂ sensor, HyPer, expressed …
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Clearance systems at brain borders
… clears metabolic waste. We observed multisensory 40 Hz stimulation promotes the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of Alzheimer’s disease, which was associated with increased aquaporin-4 polarization along astrocytic …
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Functional Aspects of Protein Kinase C FRET Probe Performance
… to be essential for the mechanism of action of a genetically encoded sensor. Based on this data, we propose the following models for the mechanism of these PKC probes: In unphosphorylated KCP-2, dimerization of fluorophores serves as a clamp, pulling the two fluorophores together to a closed, …
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Cell Signaling Components of the Drosophila Circadian Pacemaker
… and dorsolateral neurons: LNd).</p><p>Using a genetically encoded sensor to measure changes in cAMP in the living Drosophila brain, I report that PDF receptor preferentially couples to specific signaling components. These groupings vary in composition depending upon receptor identity; small LNv …
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In vitro selection of DNAzymes selective for monovalent metal ions and their development as sensors in living cells and organisms
… of environmental or live cell metal ion sensors. Potassium ion (K+) is the most abundant metal ion in all living cells and plays important biological roles. Hence, methods to detect K+ in living systems with high selectivity are invaluable to understand the precise mechanisms of K+ in …