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Showing 1 to 20 of 88 for “"genetic variations"”.
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Analysis of genetic variations associated with arrhythmogenic right ventricular cardiomyopathy
… identified; this study focused primarily on the genetic causes of arrhythmogenic right ventricular cardiomyopathy (ARVC). Many genes are implicated in ARVC pathogenesis, but many remain to be identified. We investigated a South African family (ACM2) with autosomal dominant ARVC, for whom the …
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Genetic Variations in Interferon-Induced Genes and HCV Recurrence after Liver Transplantation
Hepatitis C Virus (HCV) infection represents a worldwide pandemic and is currently the leading cause of cirrhosis and liver transplantation. After transplantation recurrence is almost universal with 96% of patients testing positive for viral RNA and exhibiting histological evidence of infection …
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Effect of nitrogen form and genetic variations of the Asparagine-cycling pathway on maize ear growth
… through the reproductive phase. The underlying genetic and physiological mechanisms for this phenomenon are currently unknown. Previous studies with DuPont Pioneer found that in the maize line Gaspé Flint, ear growth no longer responded to additional nitrate 20 days after emergence, but a …
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Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization
… complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. The aim of this thesis was to investigate gene-lifestyle interactions using the strongest T2D and CVD susceptibility genetic loci and to …
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An Assessment of the Relationship among Oxidative Stress, Adaptive Immunity and Genetic Variations in the Chicken, Gallus gallus
… well understood. In addition, the impact of bird genetic variation on redox balance remains to be elucidated. Thus, the central hypothesis of this dissertation is: The bird's adaptive immunocompetence is impacted by their OS level, which is not only influenced by environmental factors, but also …
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Individual genetic variations of eight SNPs associated with risk of obesity in preschool age children from STRONG Kids Program
… of obesity has been strongly associated with genetic predisposition. Variations in genes involved or potentially related to the leptin-melanocortin pathway (i.e. BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, TUB) have been associated with symptoms of poor appetite control and obesity-related …
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Morphological and Genetic Variations of Calyx and Fruit and Their Relation to Crack Resistance in the Tomato, Lycopersicon Esculentum, Mill
Made available in DSpace on 2014-12-12T00:57:17Z (GMT). No. of bitstreams: 1 7121091.pdf: 4173067 bytes, checksum: d4fa8beeed5b217ee097def06cfa2a08 (MD5) Previous issue date: 1971
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Occurrence of bacterial spot of pumpkin (Xanthomonas cucurbitae) in Illinois, and pathogenic and genetic variations, host range, and seed borne aspect of the pathogen
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-07-08T18:06:44Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Ravanlou_Abbasali.pdf.pdf: 3197635 bytes, checksum: 2fd43079e5eaa4c7853c4c0c33711942 (MD5)
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Assessment of genetic variations within and between populations of Marama Bean (Tylosema Esculentum (Burchell) Schreiber) based on Microsatellites (SSRS) and Intergenic spacer length variation markers in the Namibian germplasm
… In this study SSR markers were used to assess genetic diversity in natural populations of marama in the Namibian germplasm. Additionally, in the present study, the intergenic spacers (IGS) region of the large ribosomal DNA gene was amplified to assess length variation in marama bean. In the …
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Interaction between dietary factors and genetic risk for lipoprotein traits and cardiovascular disease
… This may be due to individuals having varied genetic profiles that are differentially associated with CVD. In genome-wide association studies (GWAS), genetic variations in the fatty acid desaturase gene (FADS1), which encodes the FADS1 enzyme, have been associated with blood lipid and …
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HUMAN GENETIC VARIANTS IN ESSENTIAL SPLICING FACTORS AND THEIR IMPACT ON IMMUNE PATHOLOGY
… (SFs). Here we present two unique cases in which genetic variations in two essential SFs, DExD-box polypeptide 39B (DDX39B) and U2 small nuclear RNA auxiliary factor 1 (U2AF1), contribute to altered splicing of Forkhead box P3 (FOXP3) – an immunoregulatory gene critical for regulatory T (Treg) …
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Novel Mass Spectrometric and Sampling Strategies for Investigating Neuropeptide Processing and Distribution
… determine new processing pathways, and to assess genetic variations. In some instances, however, alternative sampling approaches such as microseparation with MALDI MS detection are necessary to pre-concentrate and partially purify neuropeptides and to reduce ionization suppression effects. Here we …
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Determinants of innate immune responses to mycobacteria
… first 9 months of life, and to assess effects of genetic variations in toll-like receptors on host responses to mycobacteria. This knowledge is important for designing rational strategies for vaccination against tuberculosis.
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Reconstruction of major male and female lineages of the Strand Muslim community
… The Study has shown the ability of molecular genetic tools to give insight into the origins and history of local communities. The study was also used as a point of reference for the Strand Muslim Community project. Genetic variations of the Y-chromosome and mitochondrial DNA for the pilot …
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Prevalence and frequency spectra of single nucleotide polymorphisms at exon-intron junctions of human genes
… splicing or some are due to DNA sequence variations in human populations. Genetic variations that affect splicing have been shown to cause variation in splicing patterns and potentially are an important source of phenotypic variability among humans. Furthermore, variation in disease …
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Using network clustering to predict copy number variations associated with health disparities
… and Caucasians in the United States. Copy number variations (CNVs) are one form of human genetic variations that have been linked with complex diseases and often occur at different frequencies among African Americans and Caucasian populations. In this study, we aimed to investigate whether CNVs …
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Genome-wide association study of persistent developmental stuttering
… of DNA, or genomes, of many people to indentify genetic variations associated with a particular disease. A GWAS uses unrelated individuals, and for the purposes of this study, only those who persistently stutter, to identify common genetic variants among these people when contrasted to the …
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Genetic diversity and population structure within Botswana: association with HIV-1 infection
… is attributable to, among other factors, host genetic variation. Characterisation of human genetic variations can contribute towards understanding the genetic aetiology of HIV-1 and foster development of novel preventive and treatment strategies against HIV-1. Despite the high burden of HIV-1 …
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A comparative analysis of machine learning algorithms for genome wide association studies
Variations present in human genome play a vital role in the emergence of genetic disorders and abnormal traits. Single Nucleotide Polymorphism (SNP) is considered as the most common source of genetic variations. Genome Wide Association Studies (GWAS) probe these variations present in human …
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High-throughput platforms for investigating bioadhesion and cell migration
… With this approach, I investigated the impact of genetic variations on endothelial wound healing relevant to acute lung injury.
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