Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"genetic toggle switch"”.
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Design of a robust ratiometric sensor and a long-term memory genetic toggle switch
… yet reversible, memory device, which can be toggled between two stable states that can be maintained for long time despite stochastic fluctuations. These two circuit designs can be widely applied in many diagnostic applications, such as through engineered bacteria in the gut, and at the same …
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Spatiotemporal Characterization of Stochastic Bacterial Growth in Biofilm Environment
… microbiological experiments utilizing genetically engineered Escherichia coli. Before demonstrating the efficacy of these systems, the development of the field of synthetic biology over the past half century is reviewed, focusing on synthetic genetic circuits and their applications …
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Assessing the transition state model for cellular differentiation in vivo: a case study of zebrafish neuromesodermal progenitors
… regime, I explored a stochastic model of the genetic toggle switch and showed that by making the Wnt input time-dependent, I can recreate these rebellious cells in silico. Taken together, my work demonstrates that several predictions of the transition state model hold true within an endogenous …
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Integrated modeling of bacterial metabolism
… and from both wild-type cells and genetic mutants growing in different environmental conditions. The single-cell model is then used to examine a growth-modulating feedback circuit whose dynamics can be qualitatively altered by host-circuit interactions. To further elucidate the …
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Advances in the stochastic and deterministic analysis of multistable biochemical networks
This dissertation is concerned with the potential multistability of protein concentrations in the cell that can arise in biochemical networks. That is, situations where one, or a family of, proteins may sit at one of two or more different steady state concentrations in otherwise identical cells, …