Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"genetic targeting"”.
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The amygdala in value-guided decision making
… past can be detected using this analysis. Using genetic targeting of a sub-population of amygdala neurons, I show that this population is required for the rapid learning of an olfactory decision making task. Using in-vivo calcium imaging of this population I show that these neurons are active …
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Elucidating how αvβ3-integrin regulates neuropilin-1’s role in tumour angiogenesis in order to improve anti-angiogenic therapy
… VEGF-stimulation. Concordantly, the simultaneous genetic targeting of both molecules significantly impairs paxillin activation and focal adhesion turnover in endothelial cells, and thus inhibits endothelial cell migration, and tumour growth and angiogenesis, even in established tumours. These …
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CELL TYPE-SPECIFIC EFFECTS OF OPIOID DEPENDENCE ON CENTRAL AMYGDALA NEURONS
… to the CeA. Finally, using novel tools for genetic targeting of µOR+ neurons, I complement this profiling of CeLCPKCδ neurons by beginning to profile the μOR-expressing population of CeA neurons (CeAμOR). I describe important similarities and differences between these two overlapping …
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Specific loss power optimization in metal ferrite nanocrystals for radiofrequency stimulation of neurons
… A proposed system for such stimulation is the genetic targeting of neurons via expression of gated ion channels, and the selective stimulation of them using a transmitter-receiver pair. This thesis describes the design and optimization of such a transmitter-receiver pair that activates ion …
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Therapeutic Targeting Of Bmp2 In Nf1-Deficient Malignant Peripheral Nerve Sheath Tumors (mpnsts)
… however, therapeutic interventions targeting RAS activity have met with limited success. Using gene expression profiling, our lab identified BMP2-SMAD1/5/8 signaling pathway as a therapeutic target in MPNSTs, independent of the NRAS and MEK1/2 regulation. The overall goal of my …
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Directed evolution of split APEX peroxidase
… this strategy is limited by the specificity of genetic targeting; there are cellular regions that cannot be exclusively targeted by a single genetic tag (Chapter 1). To further advance the capabilities of APEX and address the need for an interaction-dependent proximity labeling tool, this thesis …
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Investigation of Genetic and Behavioural Determinants of Type 2 diabetes and Glycaemic Traits
… originates from a complex interplay between genetic, behavioural and environmental risk factors, the underlying mechanisms of which are unclear. The goal of this thesis was to investigate the contributions of genetic, metabolic and behavioural risk factors in the aetiology of T2D by studying …
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Using new tools to study the neural mechanisms of sensation: Auditory processing in locusts and translational motion vision in flies
… imaging into animals that are not amenable to genetic labelling techniques. Using this method in locusts and crickets – model systems of particular interest for their acoustic communication – I successfully delivered polar fluorescent dyes and tracers through the sheath covering the auditory …