Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"genetic susceptibility"”.
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Understanding functional mechanisms of genetic susceptibility to mycobacterial infection
… of the leading causes of death worldwide. Human genetic factors determine susceptibility to M. tuberculosis (M. tb) infection and predispose to clinical TB. Genome-wide association studies (GWAS) aim to discover human genes associated with susceptibility to TB. Recently, a GWAS conducted by our …
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Genetic Susceptibility to Arsenic Exposure and Arsenical Skin Lesion Prevalence in Bangladesh
… date, few epidemiologic studies have evaluated genetic susceptibility to arsenical skin lesions based on single nucleotide polymorphisms (SNPs) in antioxidant enzyme or DNA repair genes. Utilizing cross-sectional data from the 2000-2002 survey of the Health Effects of Arsenic Longitudinal Study …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… redox imbalance. Uncontrolled hyperglycaemia and genetic factors are implicated in the pathogenesis of diabetic microvascular diseases. Genetic mutation through the genes coding for enzymes involved in glucose metabolism and immuno-regulatory mechanisms may contribute to the susceptibility to type …
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Habit Formation in a Rodent Model of Alcoholism: Genetic Susceptibility, Alcohol-Specific Effects, and Pharmacological Manipulation
Habit formation is a well-characterized process involving a shift from response-outcome as the leading driving force underlying action to a stimulus-response mechanistic process. It is hypothesized that a transition from goal-directed behavior to habitual behavior is driven by a transition of the …
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Systematic analysis of genes expressed in the retinal pigment epithelium (RPE) and identification of candidates for genetic susceptibility to age-related macular degeneration (AMD)
Age related macular degeneration (AMD) is the leading cause of visual impairment in the elderly and the major cause of blindness in the developed world. To date, the molecular mechanisms underlying the disease are not well understood although in recent years a primary involvement of the retinal …
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Genetic Determinants of Obesity in Relation to Diet, Weight Gain and Mortality
… believed to be a result of interactions between genetic and environmental factors. In this thesis we investigated the role of dietary factors in modifying the genetic susceptibility to obesity (papers I to III), studied the association between genetic susceptibility to obesity and weight gain at …
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The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa
… evidence from transgenic mouse models and human genetic susceptibility studies that implicate FcyRIIa in a number of immune diseases including, rheumatoid arthritis, systemic lupus erythematosus (SLE) and immune thrombocytopenia purpura (ITP). FcyRHa is therefore a promising target for the …
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Biomarker-And Pathway-Informed Polygenic Risk Scores for Alzheimer's Disease and Related Disorders
Determining an individual’s genetic susceptibility in complex diseases like Alzheimer’s disease (AD) is challenging as multiple variants each contribute a small portion of the overall risk. Polygenic Risk Scores (PRS) are a mathematical construct or composite that aggregates the small effects of …
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Dysbetalipoproteinaemia : clinical and laboratory aspects, changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs
… of remnants of triglyceride-rich lipoproteins. Genetic susceptibility is conferred by mutations in apolipoproteinE, but manifest hyperlipidaemia often only occurs in the presence of metabolic abnormalities that influence lipoprotein production or clearance. Normal lipid metabolism is briefly …
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DNA methylation landscape in retinal degenerative diseases: implications for Public Health at the crossroad between genes and diet
… further research - which takes into account genetic susceptibility - is needed to understand the mechanistic underpinnings of retinal degeneration. In addition, we proved that resveratrol and curcumin may restore DNA methylation changes which occur in cells under oxidative, inflammatory or …
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Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations
… due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. Growing evidence indicates that patients with genetic susceptibility to cancer may be at higher than normal risk for therapy related cancers. Increased knowledge …
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A Study of the Molecular Immunogenetics of Type 1 Diabetes in Man
… showed a strong association with the susceptibility towards type 1 diabetes (p= 0.002). The TC genotype of the TGF-β1 T (+869) C polymorphism also showed a significant association with type 1 diabetes (p= 0.003). The association of the 3 I 3 genotype of the IFNG CA repeats and no …
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The KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome
… of the pathophysiological processes underlying susceptibility to poor outcomes is limited, which has impaired the development of effective therapeutics for patients with a mTBI. The present study was designed to assess behavioral and molecular changes post-mTBI in an animal model of genetic …
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Genetic and Sex Steroid Hormone Contributions to the Sexual Dimorphism in Murine Experimental Allergic Encephalomyelitis
… EAE had important implications on the degree of genetic susceptibility necessary to result in disease. We also found that of the many quantitative trait loci (QTL) identified to date, genetic linkages to mouse chromosomes 7 and 11 were strongly associated with susceptibility to EAE. Further, the …
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Investigating the role of host genetic polymorphisms in periodontitis susceptibility in a Western Cape population
… pathogenesis involves studying both host genetics and microbial factors. Research shows that genetic susceptibility varies by ethnicity, with disparities in periodontitis prevalence across populations. In South Africa, limited dental access and diverse ethnicities add complexity to …
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Genetic analysis of the microvascular complications of diabetes mellitus
There is increasing evidence to suggest that genetic factors are involved in the pathogenesis of microvascular complications in diabetes mellitus. Recent studies have suggested that genetic variations in the aldose reductase (ALR2) gene may contribute to the genetic susceptibility to microvascular …
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A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape
… allotypes strengthens the hypothesis that a genetic susceptibility exists to acquiring TB.
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A detailed investigation into potential genes and their variants regulatory sequences causing endometriosis and how the environment may impact upon these
… suggest that endometriosis may have a genetic component. The aim of this project was to carry out a detailed investigation of genetic factors and their interactions with the environment (e.g. EDCs) which potentially predispose an individual to endometriosis development. Methods A …
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Determinants of Childhood Obesity in the UK: A Systematic Literature Review
… between inherent predispositions, such as genetic susceptibility and early-life growth patterns, and modifiable factors, including family and caregiver practices, lifestyle behaviours, environmental exposures, and social-emotional contexts. Importantly, UK-specific evidence largely aligned …
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Epidemiology of diabetes in a well defined population in Sweden: the Skaraborg Diabetes Registry
… A description of the patients in terms of genetic susceptibility, autoimmune markers, beta-cell function, and insulin sensitivity would be more appropriate for identifying homogenous groups of patients for studies of epidemiology, therapeutic alternatives, and prognosis.
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