Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"genetic sequences"”.
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Matching Genetic Sequences in Distributed Adaptive Computing Systems
Distributed adaptive computing systems (ACS) allow developers to design applications using multiple programmable devices. The ACS API, an API created for distributed adaptive com-puting, gives developers the ability to design scalable ACS systems in a cluster networking environment for large …
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An outcome-based statistical framework to select and optimize molecular clustering methods for infectious diseases
Collecting genetic sequences from infectious pathogens allows for the construction of molecular clusters: groups of cases with genetically similar pathogen populations. These imply outbreaks, but the methods used to create them often require a threshold to qualify clusters (ie. 99% average pairwise …
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The development of a nanoscale Coulter counter for rapid genetic sequence recognition
… for the direct electrical detection of specific genetic sequences of deoxyribonucleic acid (DNA); the general approach used to accomplish sequence recognition is a refinement of the resistive pulse technique. Commercial Coulter counters fabricated with sub-micrometer apertures can size particles …
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The alien presence: Palaeoentomological approaches to trade and migration
… palaeoentomological remains to yield assayable genetic sequences. Ancient DNA was recovered from preserved Roman and medieval specimens. If aDNA preservation is widespread in palaeoentomological remains, a phylogeographic method is conceivable as a means for assessing past trade and migration.
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Capsid catalysis : de novo enzymes on viral proteins
… semisynthetic enzymes remain linked to the genetic sequences responsible for catalysis, future work could tailor the biocatalysts to high-demand synthetic processes by evolving new activities, utilizing high-throughput screening technology and harnessing M13's multifunctionality.
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Applying engineering principles to the design and construction of transcriptional devices
… then to biological parts, and finally to genetic sequences. Standardization is used to make the process of engineering a multi-component system easier. I then focus on devices that implement digital information processing through transcriptional regulation in Escherichia coli. For …
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Secure Discovery of Genetic Relatives across Large-Scale and Distributed Genomic Datasets
… and secure federated algorithm for identifying genetic relatives across data silos. SF-Relate vastly reduces the number of individual pairs to compare while maintaining accurate detection through a novel locality-sensitive hashing approach. We assign individuals who are likely to be related …
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Real-time Three-Dimensional DNA Microarrays: How Well Can We Distinguish Between Related Target Sequences?
… space to be explored can be very large, the genetic sequences of many species are very similar, and the concentrations at which the different species are present is typically not known at the time of the sample collection, which can result in complex overlapping hybridization patterns. There …
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Hybrid nanostructure designs facilitated by M13 virus for lithium ion battery and lithium air battery electrodes
… was improved. By rationally designing genetic sequences of the M13 virus, graphene sheets were homogeneously distributed throughout bismuth oxyfluorides cathodes as conducting paths. Second, large surface area cathodes were developed with virus-templated manganese oxide nanowires. These …
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PRIVATIZING AGRICULTURAL GENETICS: AN ANALYSIS OF THE PROCESS AND IMPLICATIONS OF CREATING PROPERTY FROM A ONCE RES NULLIUS PUBLIC GOOD
For milennia, agricultural genetics were common-pool, open access (or res nullius) resources, unencumbered by the assignment of property rights. Beginning in 1930, a series of legislative and judicial actions incrementally altered the legal definition of agricultural genetics and, ultimately, …
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Large-scale methods for multiple sequence alignment and phylogeny estimation
Bioinformatic analyses generally involve passing genetic sequence data through a pipeline of transformations. These prominently include multiple sequence alignment (MSA) and phylogeny estimation, which are both core challenges in computational biology. Their established mathematical formulations …
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CRISPR-based functional genomics to study gene regulatory architecture and consequences of genetic variation
… The coding portion of the genome contains the genetic template for RNA transcription and protein translation, and translated proteins are the functional units of the cell that carry out biological function. Despite coding genes acting as templates for RNA transcription and protein translation, …
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Modeling the effects of site-specific amino-acid preferences on protein evolution.
… of protein evolution is understanding which genetic changes that fixed in nature were selected for and why. However, understanding the functional consequence of any given mutation is a challenge because the effects of amino-acid changes are highly idiosyncratic across sites in a protein. My …
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Molecular and Field Analyses of Bathyplectes spp. (Hymenoptera: Ichneumonidae) in Alfalfa Systems in Virginia
… by the population functional response, and genetic variation among and between populations of parasitoids. GPS-referenced quadrat sampling was conducted in alfalfa fields in the Piedmont and southwestern region to assess alfalfa weevil population levels and spatial distribution, and the …
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Sequence-structure correlations in the MaSp1 protein of N. clavipes dragline silk
… assemblies, in particular under variations of genetic sequences, have been published. Here, atomistic-level structures of wildtype as well as modified MaSp1 protein from the N. clavipes spider dragline silk sequences are reported, obtained using an in silico approach based on replica exchange …
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IDENTIFICATION AND CHARACTERISATION OF POTENTIALLY NOVEL HERPESVIRUSES IN VERTEBRATE SPECIES
… non-adapted hosts, which can lead to severe consequences. Non-adapted hosts typically lack the evolutionary adaptations necessary to effectively control the virus, resulting in increased viral pathogenicity and significant clinical disease. Based on biological and phylogenetic characteristics …
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High-throughput protein engineering tools for efficient exploration and quantitative mapping of protein fitness landscapes
… the nearly boundless search space of amino acid sequences resulting from the combinatorial explosion of possible mutations, and (2) the complex sequence-function relationships that make it challenging to rationally narrow down the vast sequence search space to a functionally relevant search space …
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Models and Methods in Cultural and Social Evolution
… recent common ancestor (MRCA) of a sample of genetic sequences or of a group of individuals. Here we introduce a model of cultural genealogies that is a step toward answering similar questions for cultural traits. In our model individuals can inherit from a variable, potentially large number …
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The Major Histocompatibility Complex in Rabbits
… extracellular peptides to CD4+ T-cells. The genetic diversity of MHC molecules is exhibited by their polymorphism, particularly in their antigen-binding regions. This polymorphism is maintained by mechanisms of balancing selection, such as heterozygote advantage and rare allele advantage. …
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Novel molecular engineering approaches for genotyping and DNA sequencing
… has increased the need for investigation of genetic sequences and their biological functions, which will significantly contribute to the advances in biomedical sciences, human genetics and personalized medicine. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry …
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