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Showing 1 to 3 of 3 for “"genetic robustness"”.
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Causes and Consequences of Genetic Robustness and Fragility in HIV-1 Proteins
<p>Genetic robustness describes a capacity to maintain function in the face of mutation. RNA viruses, like human immunodeficiency virus-1 (HIV-1), experience extremely high mutations rates in vivo, which contribute to the evolvability that permits HIV-1 to evade immune defenses. However, the …
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Utilizing Haplotypes For Sensitive Snp Array-Based Discovery of Somatic Chromosomal Mutations
… to sensitive detection of these mutations is genetic heterogeneity and high levels of contaminating normal cells in tumor samples, which limit the fraction of cells carrying informative mutations. The method presented here is the first method to utilize population-based haplotype estimates to …
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Probabilistic Reconstruction and Comparative Systems Biology of Microbial Metabolism
… I present two projects related to population genetics aspects of sequence and genome evolution. The first project addresses the question of why highly expressed proteins evolve slowly, showing that, at least for Escherichia coli, this is more likely to be a consequence of selection for …