Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"genetic risk scores"”.
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Translating autoimmune genetic risk scores into improved prediction and classification of disease
The clinical translation of established genetic risk for type 1 diabetes is hindered by a lack of standardisation and understanding of disease heterogeneity. This thesis aims to address these issues by utilising genetic risk scores (GRS) to enhance type 1 diabetes prediction, differential …
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Are maternal symptoms of depression/PTSD and Child Genetic risk scores for depression/PTSD associated with childhood subcortical brain volumes?
The antenatal period is a critical window for genetic and environmental factors to influence a child's brain development. While previous research in East Asian and European populations has linked child polygenic risk scores (PRSs) for depression and maternal antenatal symptoms (E) to child …
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Statistical co-analysis of high-dimensional association studies
… (JIA) to adult diseases, using modified genetic risk scores and linear discriminants in a penalised regression framework. The contribution of this thesis is in a range of methodological developments in the analysis of high-dimensional association study comparison. Methods such as these …
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Early life phenotypes of type 1 diabetes genetic risk
… in ~600 children and used to derive high-risk T1D HLA haplotypes and genetic risk scores. Examination of data in the CBGS defined the contributors to physiological growth and set the framework for analyses. My findings concurred with most prior studies on the lack of an effect of the SNP …
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Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization
… complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. The aim of this thesis was to investigate gene-lifestyle interactions using the strongest T2D and CVD susceptibility genetic loci and to …
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The interplay between genes and dietary factors in the aetiology of Type 2 Diabetes Mellitus
… it is crucial to understand its aetiology. Both genetic and the environmental risk factors are known to be involved. Healthy diets have been proven to reduce the risk of T2D in primary prevention trials, however, which components and exact mechanisms are involved is not fully understood, in …
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Leveraging the microbiome in host genome wide association studies
… has emerged as an effective method for detecting genetic polymorphisms associated with expressed phenotypes. Over the past decade, GWAS of human traits and diseases has revolutionized the field of complex disease genetics, identifying hundreds of genetic variants associated with several different …
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Genetic and dietary determinants of Type 2 diabetes in a black South African population
… Westernised lifestyles among people who have a genetic predisposition to T2D is fuelling this epidemic. However, it is not clear which nutrient factors and genetic factors interact to increase T2D risk in the black South African population. We set out to determine 1) the predictive utility of …
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Investigation of Genetic and Behavioural Determinants of Type 2 diabetes and Glycaemic Traits
… originates from a complex interplay between genetic, behavioural and environmental risk factors, the underlying mechanisms of which are unclear. The goal of this thesis was to investigate the contributions of genetic, metabolic and behavioural risk factors in the aetiology of T2D by studying …