Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"genetic risk factors"”.
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Genetic risk factors for carpal tunnel syndrome
… of the median nerve. Although several factors are believed to be associated with increased risk of CTS, the direct causes of this injury remain unknown and it is generally accepted that CTS, with the exception of acutely caused CTS, is a multifactorial condition. Although it is …
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Genetic risk factors for anterior cruciate ligament ruptures
… be associated with ACL ruptures, and then use a genetic association approach following a case-control study design to identify specific sequence variants (single nucleotide polymorphisms, SNPs) within these candidate genes which may predispose individuals to ACL ruptures. Candidate genes (COL1A1, …
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Genetic risk factors for overuse and acute musculoskeletal injuries
… interaction of several intrinsic and extrinsic risk factors. There is a growing body of evidence suggesting that inherited genetic elements may predispose an individual to injury risk and should therefore be considered as important intrinsic risk factors. Previous studies have investigated the …
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Etiology of congenital anorectal malformations : genetic and non-genetic risk factors
Contains fulltext : 150170.pdf (Publisher’s version ) (Open Access)
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White matter connectivity, cognition, symptoms and genetic risk factors in Schizophrenia
… potential relationships between them due to the genetic overlap shared among these factors. This work investigates the psychopathology of schizophrenia from a neurobiological, psychological and genetic perspective. The datasets used here include data from the Scottish Family Mental Health (SFMH) …
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Epidemiology and genetic risk factors of suicidal behaviour in South Africa
… social, environmental, and biological factors, that are not fully understood. Given the considerable societal cost associated with suicide and health inequality in South Africa, there is a critical need to determine the burden of suicide and risk factors associated with suicide, to …
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Heredity in Parkinson's disease. From rare mutations to common genetic risk factors.
This study investigated genetic causes of Parkinson's disease (PD) and parkinsonism in southern Sweden. The extensive Lister Family with parkinsonism caused by duplications and triplications of the gene for alpha-synuclein (SNCA) was studied. Clinical, genetic and genealogical data were compiled …
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Genetic Risk Factors for PTSD: A Gene-Set Analysis of Neurotransmitter Receptors
… pathogenesis of PTSD is not well understood, and genetic mechanisms are particularly elusive. Neurotransmitter systems are thought to contribute to PTSD etiology and are the targets of most pharmacotherapies used to treat PTSD, including the only two FDA approved options and a wide array of …
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Study of the Phenotypic Characteristics and Genetic Risk Factors of Primary Sclerosing Cholangitis
… leading to biliary cirrhosis, with an increased risk of colorectal and hepato-biliary malignancy. It is commonly associated with inflammatory bowel disease (IBD). Specific medical therapy is ineffective and for patients who develop end-stage liver disease, liver transplantation remains the only …
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Whole genome sequencing approach to identifying genetic risk factors underlying anterior cruciate ligament injuries in a twin family study
… a complex interplay of intrinsic and extrinsic risk factors. Variation in the genome is now considered a key intrinsic risk factor, but the majority of currently implicated loci have been identified through case-control genetic association studies, which are limited by a candidate gene approach …
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Ethical, Legal and Social/Societal Implications (ELSI) of Recall-by-Genotype (RbG) approaches in the Cooperative Health Research in South Tyrol (CHRIS) study on genetic risk factors of Parkinson’s disease (PD)
… with eligible participants. They use specific genetic information derived from pre-vious genome-wide association studies or whole-genome sequenc-ing enabled by next-generation sequencing. Genetic information may be partially disclosed when certain partici-pants are recalled for RbG studies, and …
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Utility of inbreeding coefficient and sire as predictors for osteochondrosis risk in Standardbred horses
… intervention. Both environmental and complex genetic risk factors play a role in the development of OC. However, no specific risk genes have yet been identified that could be used to quantify genetic risk at the level of the individual. Sire effects on risk of OC have been reported, but …
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Analysis of the genetic and epidemiological contributors to aging-related traits in the Diabetes Heart Study
… actions in the peripheral tissues. T2D increases risk for a number of age-related comorbidities, including cardiovascular disease and cognitive decline. Risk of these comorbidities is thought to be influenced by both clinical factors, including differences in treatment, lifestyle, and environment, …
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Examining Alcohol Dependence and Its Correlates From A Genetically Informative Perspective
… disciplines, including developmental psychology, genetic epidemiology, and molecular genetics, to achieve our current understanding of environmental and genetic risk factors for AD as well as its variable developmental trajectories. Nevertheless, there is still much to be learned in order to …
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UNRAVELLING THE MOLECULAR BASIS OF ALZHEIMER¿S DISEASE AND FRONTOTEMPORAL DEMENTIA: GENETIC AND EPIGENETIC APPROACH THROUGH NEXT GENERATION SEQUENCING AND OPENARRAY TECHNOLOGIES
… complex heterogeneous disorders with a strong genetic background, but the identification of a genetic cause is difficult given the multifactorial aetiology of the disorders. Epigenetic and environmental factors interplay to influence this complexity. The aim of the present project was to …
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Computational methods for genomic variant calling and analysis
… medicine to diagnose and treat disease. The genetic polymorphisms identified by this high-throughput sequencing can serve as markers for association with phenotypic traits. Variant calling refers to the process of detecting genetic polymorphisms based on analysis of genome sequence data …
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In vivo Examination of Peripheral Drivers of Alzheimer’s Disease
… subjects, we found that even in the absence of genetic risk factors for AD, elderly mice submitted to recurrent hepatotoxicity since an adult age display memory impairment congruent with persistent, but not robust deleterious changes to AD-relevant regulators in the brain and periphery. In …
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Revealing Mechanisms of Sporadic Alzheimer’s Disease by Modelling in Organotypic Hippocampal Slice Cultures
… of inflammation. Neuropathology and some known genetic and environmental risk factors help give clues as to the pathogenesis of AD, but we still lack a fundamental knowledge of how exactly this disease comes to fruition. Many environmental risk factors have now been associated with an increased …
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GENETIC AND BIOCHEMICAL ANALYSIS OF TYPE 2 DIABETES AND DIABETIC COMPLICATIONS
… as to why individuals with T2D have an increased risk for CVD have been proposed. These include: high glucose independent of other risk factors, the atherogenic profile of diabetes (i.e. dyslipidemia, hypertension, obesity, etc.) often termed the “common soil” hypothesis, or that it is common …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… from failure of thrombus resolution. Identifying genetic risk factors for CTEPH would provide important insights into pathobiology and might allow risk-stratification following PE. A genome-wide association study (GWAS) was performed in 1250 CTEPH patients, 1492 healthy controls and ~7 million …
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