Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 80 for “"genetic predisposition"”.
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Impaired awareness of hypoglycaemia in type 1 diabetes. Prevalence, genetic predisposition and mortality
Contains fulltext : 183427.pdf (Publisher’s version ) (Open Access)
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SARCOPENIA, LIVER AND CARDIOVASCULAR ALTERATIONS IN A MULTICENTRIC COHORT OF PATIENTS WITH MASLD: EVALUATION OF CLINICAL PRESENTATION AND GENETIC PREDISPOSITION
… advanced liver fibrosis, and share common pathogenetic mechanisms such as insulin-resistance (IR), low-grade chronic systemic inflammation, mitochondrial dysfunction, and oxidative stress. Additionally, genetic predisposition plays a role in MASLD, with specific polymorphisms in PNPLA3, TM6SF2, …
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Saying ‘No’: A biographical analysis of the experiences of women with a genetic predisposition to developing breast/ovarian cancer who reject risk reducing surgery
Background: Genetic technologies have identified some of the genes implicated in cancer susceptibility. Women with mutations in breast/ovarian cancer-susceptibility genes (BRCA1 and 2) have a lifetime combined risk of breast/ovarian cancer of more than 80%. Risk reducing surgery (RRS) reduces …
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Autonomy and genetic predisposition: The relationship between original organizational configuration and the tendency for autonomy. An analysis of three drop-in centres servicing street youth
… using a combination of Angelo Panebianco's genetic model and literature specific to non-profit organizations and their development. Long-term behavioural patterns were examined through a longitudinal overview of fundraising and policy making practices. This mode of analysis yields a unique …
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Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes
… individuals both with and without known genetic predisposition to T2D. This thesis is part of the research conducted at Lundberg laboratory for diabetes research, Institute of Medicine, Sahlgrenska Academy, at Gothenburg University. In study I, we aimed to investigate if markers of …
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Genetic analysis of hoof traits
… from University of Illinois dairy farm for genetic analysis were all inside 80% range of reference herds. Estimated heritabilities based on Snell transformed scores were.05,.12,.06,.14,.02 and.08 for corkscrew claw, heel erosion, interdigital dermatitis, laminitis, sole ulcers and white line …
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The role of fruit colour in avian fruit selection: an objective approach
… blackcaps prefer red fruits and might have a genetic predisposition. Black and white fruits have high tannin content, some red, orange and yellow fruits show high protein contents. The unexplained biological activity of tannins and the unknown avian visual system leave the correlation unclear. …
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The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice
… effects of cancer risk factors such as exposure, genetic predisposition and age on homologous recombination in vivo. To determine the effect of exposure to exogenous carcinogens on homologous recombination, FYDR mice were treated with two different chemotherapeutic agents, cisplatin and …
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Eating behaviour and the aetiology of obesity
… was used to interrogate: (1) the role of EB in genetic predisposition to obesity, (2) the interaction between infant EB and maternal attitudes in the determination of infant milk intake and weight and (3) the genetic basis of EB traits and risk-taking. First, the effect of body mass index …
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Immanuel Kant's Sparrow
… be displayed by a species. These included (1) a genetic predisposition, (2) body condition of the parents, (3) food availability during early ontogeny, (4) social factors, (5) neuronal mechanisms, (6) hormonal states, and (7) body size and morphology of the vocal tract. House sparrows singing …
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Source activity and tonotopic organization of the auditory cortex in musicians and non-musicians
… support for the hypothesis of a predominant genetic predisposition of music aptitude proposed by Gordon (1987). The early source activity of the primary auditory cortex revealed a strong logarithmic organization (the lower frequencies more superficial, 2.3 mm/octave), the late activity at 100 …
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Correlation between pro-inflammatory alleles and clinical and laboratory markers of allergy in Xhosa South Africans
… are the result of a complex interaction between genetic predisposition and environmental exposure. It is likely that multiple genes are involved in the progression from allergen exposure to the development of signs and symptoms of allergic disease. Although advances in genetic research have …
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Molecular and genetic characterisation of contralateral breast cancer (CBC): opportunities for personalised surgery
This thesis outlines a molecular epidemiology and genetic sequencing study carried out to investigate the relationship between primary and contralateral breast cancers (CBCs). Additionally, given the known risk factors for CBC development of young age at primary diagnosis and significant family …
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The role of genetic and environmental variation in the respiratory phenotype of alpha 1 antitrypsin deficiency
… deficiency (AATD) is the only established genetic predisposition to chronic obstructive pulmonary disease (COPD). The development of COPD in AATD is highly variable, probably relating to complex interactions between multiple genetic and environmental factors. This thesis will describe the …
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‘The missing discourse’: how does the family history of cancer affect the care needs of palliative care patients?
… and growing public awareness of the influence of genetics on the development of cancer. It is known that up to ten percent of cancers are associated with a genetic predisposition. This study asks ‘How does the family history of cancer affect the care needs of palliative care patients?’ in this …
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L-NAME- Induced Hypertension in the WKY and BHR Rat
… endothelial-derived relaxing factor. The BHR is genetically predisposed to developing hypertension in response to chronic exposure to environmental stress. After normalizing for initial systolic blood pressure (SBP), rats received drinking water that contained N-nitro-L-arginine methyl ester …
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Quality Management: A Global Case Study in Organ Transplantation
… failure from a multitude of reasons: cancer, genetic predisposition, exposure to harmful chemicals in home or surrounding areas or through drinking, drugs and smoking. Another problem faced, is the ratio of organ donors to organ recipients. Over 121,000 patients are on the waiting for an organ …
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Mitochondrial Dysfunction: A Mechanistic Link in the Progression from Normal Aging to Sporadic Alzheimer’s Disease
… human genome sequencing data, we identified genetic variants of mitochondrial proteins as putative causal factors for AD. Our results indicate that genetic predisposition and aging-related mitochondrial Aβ sequestration contribute to synaptic mitochondrial dysfunction during the transition …
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Geographic Differences in the Risk of Surgery in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
… of these disease is not well understood but genetic predisposition, dietary and microbiome-related factors, and environment exposures have been previously implicated. These diseases have traditionally been thought of as diseases of Caucasians living in the Western world: North America, …
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Molecular genetic investigations of renal cell carcinoma predisposition
… (RCC) are a diverse group of histologically and genetically distinct renal neoplasms accounting for 2.4% of all cancers worldwide. While a majority of RCC cases are sporadic in nature, a proportion are due to genetic predisposition caused by syndromic and non-syndromic conditions. Inherited renal …
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