Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"genetic network"”.
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Genetic network regulating variation in vegetative phase change in maize
… variation of leaf identity traits in diverse genetic mapping populations indicates the feasibility to use quantitative trait locus (QTL) analyses to find underlying genes. I demonstrate here that Glossy15 (Gl15) is the most important gene controlling leaf identity traits in maize. Decreased …
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Incorporating diverse data to improve genetic network alignment with IsoRank
… have the same function (orthologs), I extend the network-alignment algorithm IsoRank to simultaneously align multiple unrelated networks over the same set of nodes. In addition to the original protein-interaction networks, I align genetic-interaction networks, gene-expression correlations, and …
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GENETIC NETWORK CONTROLLING FEMALE GAMETOPHYTE AND EMBRYO DEVELOPMENT IN ARABIDOPSIS THALIANA
The aim of the research performed is the molecular understanding of genes regulating embryo sac development. The identification of genes involved in female gametophyte formation is of significant interest since they are of great importance for plant reproduction. In the last year, different …
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A Mathematical and Engineering Framework to Predict the Effect of Resource Sharing on Genetic Networks
… effect of resource sharing on the performance of genetic networks. A model of a genetic system with shared resources for protein degradation is developed that captures resource sharing effects and is subsequently analyzed to discover ways in which this form of resource sharing effects genetic …
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Engineered E. Coli That Detect and Respond to Gut Inflammation Through Nitric Oxide Sensing
… and characterization of a synthetic genetic network that is intended for use by E. coli within lumen of the intestine, which is presumed to be a safer location than other tissues, such as blood, for the introduction of engineered microbes. The synthetic gene regulatory circuit …
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Genomic applications of statistical signal processing
… proteins. These interactions can be modeled by genetic regulatory networks (GRNs). This dissertation proposes to reverse engineering the GRNs based on heterogeneous biological data sets, including time-series and time-independent gene expressions, Chromatin ImmunoPrecipatation (ChIP) data, gene …
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Learning from Disorder and Noise in Physical Biology
… about the architecture of the underlying genetic network and make quantitative predictions using the entire content of experimentally realistic time-series data. Finally, we will break down the process of GBE using node-based Monte Carlo simulations to show that while anisotropic tension …
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Genetic dissection of carotenoid concentration and compositional traits in maize grain
… gain may be more predictably achieved if: 1) the genetic network regulating biological functions which contribute to carotenoid accumulation was better understood; and 2) the relative effect of the genetic loci controlling this quantitative trait was known, especially in varying genetic …
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Signal specificity amongst STAT1- and STAT3- inducing cytokines in the context of Th17 differentiation
… of these three chapters, we propose a simple genetic network which is capable of translating IL-6's high amplitude, transient STAT3 signal into a pro-inflammatory response and IL-10's low amplitude, sustained STAT3 signal into an antiinflammatory response. This network is able to predict that …
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Molecular mechanisms regulating implantation
… Our results uncovered an intricate genetic network operating downstream of STAT3 that regulates uterine epithelial junctional reorganization, stromal proliferation and differentiation, which are critical determinants of successful implantation. In the fourth chapter of this thesis we …
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Regulation and switching in bacterial gene expression networks in response to nutrients
… overall fitness of the species. The underlying genetic network plays a key role in the mechanisms that govern phenotypical variation. Many notable examples have been identified and principles and molecular mechanisms governing cell decision making have been extensively investigated. In this …