Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"genetic mechanisms"”.
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Molecular genetic mechanisms of eosinophil activation in aspirin-exacerbated respiratory disease : Genetic mechanisms of eosinophil activation
… a potential association of IL5, IL5RA and P2RY12 genetic polymorphisms in the susceptibility to asthma and AERD in a Korean population. Materials and Methods: The two study groups, 310 adult asthmatics and 160 normal controls (NC), were enrolled at Ajou University Medical Center, Suwon, South …
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Molecular and Genetic Mechanisms in Atopic Eczema
… activity within the fieldof atopic eczema genetic research, stimulated by the discovery, in 2006, of loss-of-function mutations in the gene encoding filaggrin (FLG). FLG null mutations play a major role in eczema and other atopic diseases and my work has built on this seminal discovery. I …
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IDENTIFYING THE GENETIC MECHANISMS IN SEIZURE THRESHOLD REGULATION
… of seizure threshold and has been shown to have genetic influences. Expression of neuronal cyclooxygenase-2 (COX-2) gene, PTGS2, a primary gene that regulates prostaglandin synthesis in the normal brain, is enhanced by excitatory neurotransmission and is under tight regulation of …
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NON-GENETIC MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
Acute Myeloid Leukemia (AML) is the most common type of acute hematological malignancy in adults. 40–60% of patients relapse due to the emergence of cellular resistance to anti- leukemic drugs. Drug resistance in leukemic cells has been associated with intratumoral heterogeneity, among which …
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The Cellular And Genetic Mechanisms Underlying Morphological Diversity Of Insects
… While basic information regarding the genetic mechanisms that regulate the size of the T3 legs became available in the past several years, virtually nothing is known about cellular mechanisms involved. To address this issue, we measured the relative mitotic activity (RMA) in <i>Acheta …
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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia
… ALL, improving our understanding of the genetic basis of childhood acute lymphoblastic leukemia (ALL). Recent genome-wide association studies (GWAS) have identified germline genetic variations of ARID5B and, more recently, IGF2BP1 that are associated with susceptibility to ALL. …
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The genetic mechanisms that coordinate the development and morphological divergence of Drosophila genital structures
… these structures are known to some extent, the genetic differences causing phenotypic divergence are not well understood. Drosophila simulans and D. mauritiana exhibit striking morphological differences in the size, shape, and bristle composition of the male periphallic genitalia, despite only …
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Cellular and genetic mechanisms of new tissue production in the regenerating planarian Schmidtea mediterranea
… a source for new cellular material as well as mechanisms to specify, differentiate, and pattern the regenerate. The planarian Schmidtea mediterranea is a classic system for studies of regenerative biology in which proliferating cells known as "neoblasts" provide the source of new cellular …
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Oncogenic KRAS drives heterogeneity in metabolic and signalling pathways through genetic and non-genetic mechanisms
… research into PDAC and KRAS, the impact of both genetic and non-genetic variability during the earliest steps of carcinogenesis are scantly described. We hypothesise that both forms of heterogeneity might alter the efficiency of PDAC initiation. On the one hand, oncogenic KRAS alleles might …
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Systems View Of The Soybean Genetic Mechanisms Involved In The Response To Plant Pathogen Infection
… a rich information resource for breeders and geneticists working towards improving traits for pathogen resistance.Results reported here provide a systemic view at both the genetic and biochemical level, and were generated by data-mining gene expression data from soybean cultivars inoculated …
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Unraveling The Genetic Mechanisms Involved In The Evolution And Development Of The Thoracic Appendages In Insects
<p>Insects display the greatest amount of structural and functional variation among animal groups, particularly in regard to their appendage morphology. These differences can range from the diverse pigmentation patterns between fore- and hindwings to changes in the size and shape of legs. The …
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Exploring the genetic mechanisms underlying superficial scald development and prevention in apple fruit during postharvest storage.
… process influenced by various factors, including genetic background, storage conditions and preharvest management practices. Recent research partially disclosed the molecular mechanisms underlying the development of superficial scald in apple fruit. It has been shown that this disorder is …
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Genetic Mechanisms Responsible for Dietary Restriction Dependent Lifespan Extension in Drosophila Melanogaster: A Role for Muscle Tissue
<p>Dietary Restriction (DR) is a robust intervention that is known to extend lifespan and increase spontaneous activity in multiple species. Whether activity increase plays a causal role in mediating the health protective benefits of DR remains unknown. To investigate this relationship, nutritional …
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Investigating the Effects of Sodium Benzoate on Fat Deposition, Pharyngeal Pumping, and Related Genetic Mechanisms in Caenorhabditis elegans
Sodium benzoate is a widely used food preservative common in many household products due to its antibacterial and antifungal activities. However, many of its side effects other than as a preservative has been under research as of late to try and assess the validity of it being a generally regarded …
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Genetic mechanisms contributing to antimicrobial resistance: gene repression in Mycobacterium, gene transfer in Salmonella, and phage sensitivity in Escherichia
… resistance to antimicrobial agents through genetic mutation or horizontal acquisition of genetic material from resistant cells. Mycobacterium, Salmonella, and Escherichia are all capable of causing disease, and each demonstrates increasing resistance to conventional antibiotic treatment. …
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Genetic regulation of dietary restriction-induced longevity in Caenorhabditis elegans
… stroke in humans. Clearly, identification of the genetic mechanisms underlying these protective effects of DR would have profound implications for the development of novel medical interventions affecting diseases of aging. Recent studies of model organisms have revealed many genetic pathways that …
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Genetic Regulation of Maize and Sorghum under Abiotic Stress
… resilience in agronomic crops and understand the genetic mechanisms conferring adaptation to water-limited environments.
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Implications of the interactions between genetic background and dietary phosphorus on porcine muscle
… in this area, little research has examined the genetic mechanisms underlying the control of P utilization. Lack of understanding of the molecular response of skeletal muscle to dietary P and the influence of genetics has hindered our understanding of P homeostatic mechanisms. The objectives of …
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Genetic and Hormonal Regulation of Worker Behavioural Development in Honey Bees
How such plastic physiological and genetic regulation mechanisms for behavioral development might have evolved in the highly eusocial insects has been studied only theoretically. I performed three experiments with male honey bees (drones) to investigate how mechanisms regulating worker behavioral …
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The genetics of parallel evolution: a case study using thermal and non-thermal ecotypes of Mimulus guttatus from Yellowstone National Park
Understanding the genetic mechanisms of adaptation has long been a goal of evolutionary biologists. However, the predictability of genetic change across adaptive events and the patterns observed during adaptive transitions across species remain poorly understood. Numerous parallel evolutionary …
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