Global ETD Search
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Showing 1 to 5 of 5 for “"genetic linkage analysis"”.
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New Score Tests for Genetic Linkage Analysis in a Likelihood Framework
<p>Linkage analysis has been the successful primary tool for mapping many Mendelian traits and some complex traits until the genetic analysis paradigm shifted from rare Mendelian disease mapping using family data to the common variant-common disease mapping mainly using unrelated case-control data, …
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Genetic Networks Modulating Retinal Injury
… also define CNS repair mechanisms by identifying genetic networks that underlie the temporal changes of retinal wound healing. Gene expression changes in the injured rat retina were analyzed with microarray technology, genetic linkage analysis of gene expression, and higher-level bioinformatic …
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FROM DISEASE TO THE GENE - Identification of arthritis-regulating loci in rats
… aetiology involving both environmental and genetic factors. Large efforts have been directed towards the understanding of the molecular mechanisms underlying RA. Because of the complexity of the disease in humans, animal models for RA have become attractive tools for gene-identification. Use …
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Genetic Determinants of Human Serum Sterol Levels
… serum levels of this sterol substrate. In the genetic linkage analysis, a SNP in CYP39A1 was strongly (P=2.1 x 10-27) correlated with serum 24-hydroxycholesterol levels. Expression analysis indicated that this SNP also decreased CYP39A1 enzyme activity. Together, these results illustrate that …
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A molecular investigation of the novel gene underlying autosomal dominant retinitis pigmentosa in a South African family
… was also incorporated into this investigation. Genetic linkage analysis facilitated the mapping of the disease phenotype in the two South African adRP families to a 10 cM interval on chromosome 17q22. This novel locus, designated RP17, is the eighth identified for adRP. Haplotype construction in …