Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"genetic heterogeneity"”.
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An investigation of genetic heterogeneity in a biological sentinel species (Lumbricus rubellus)
… the existence of several possible sources of genetic heterogeneity within the sentinel species Lumbricus rubellus that could compromise its suitability for ecotoxicological assessment. The species appears to consist of two genetically divergent cryptic lineages and has been demonstrated to …
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Time to quit? Non-genetic heterogeneity in cell fate propensity after DNA damage
… cell cycles and the transmission of unresolved genetic lesions from one phase to the next. Furthermore, these mechanisms are also believed to underpin the responses of cells, both in normal and cancerous tissues, to those therapies that either directly or indirectly generate DNA damage. In …
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Genetic Heterogeneity of Residual Variance for Production and Functional Traits in American Angus Cattle
… is evidence that residual variance may be under genetic control, which opens the possibility of selecting for uniformity. In this sense, the objectives of the present dissertation were: 1) to investigate the extent of genetic heterogeneity of residual variance at the pedigree level in birth …
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Apobec1-Mediated RNA Editing in Monocytes Contributes to Genetic Heterogeneity and Modulates Monocyte Activity and Development
<p>Post-transcriptional modifications such as alternative splicing have been shown to add to the complexity needed to compensate for the relatively low number of genes found in higher organisms. Many other modifications recently found in mRNA, which cannot be deduced from what is coded in the …
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Analysis of the effect of genetic heterogeneity on de novo genome assembly using Xylocopa virginica as a model.
… (NGS) technology has revolutionized genomic and genetic research, and as a result, de novo genome sequencing and assembly for non-model organisms has now become a common task in genome research. However, the integral properties of a genome such as ploidy, mutations, and repeat content impose …
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Multiplexed biochemical imaging reveals the extent and complexity of non-genetic heterogeneity in DNA damage-induced caspase dynamics.
Genetically identical cells show a heterogeneous response to a multitude of signals such as growth factors and DNA damage. While this heterogeneity has been shown to be a major determinant of treatment success in several diseases including cancer, little is known about how differences in …
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Spatial and Temporal Genetic Heterogeneity in a Natural Daphnia Population: Ecological and Physiological Differences Between Genotypes (Cladocera, Freshwater, Parthenogenesis)
… and one-half year study of spatial and temporal genetic heterogeneity in a population of the cyclically, parthenogenetic cladoceran, Daphnia pulex, inhabiting a permanent farm pond in east-central Illinois, indicated that electrophoretically distinct genotypes (clones) are frequently distributed …
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The molecular ecology of Vaccinium macrocarpon Aiton, the American cranberry
… The objective of this project was to investigate genetic and clonal variation and phenotypic plasticity of V. macrocarpon. Specifically, I wanted to test whether there exists an inverse relationship between population genetic variation and the amount of overall phenotypic plasticity of vegetative …
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MIR-181A/B INHIBITION AS A NEW STRATEGY FOR MITOCHONDRIAL DISEASE TREATMENT
… range of clinical phenotypes. MDs show extreme genetic heterogeneity, which makes the development of efficient treatments particularly difficult. Indeed, despite recent progress, no effective therapies are currently available. Gene/mutation-independent approaches targeting downstream affected …
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Family and tumour studies in breast and oesophageal cancer
… cancer susceptibility. The initial area was the genetic analysis of a recently mapped breast cancer susceptibility locus, BRCAl, in a number of breast and breast-ovarian cancer families. In the largest of the ICRF families studied (BOV3), linkage to the long arm of chromosome 17 was confirmed and …
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DawnRank: discovering personalized driver genes in cancer
… cancer genomic studies have revealed that the genetic heterogeneity of the same type of cancer is greater than previously thought. A key question in cancer genomics is the identification of driver genes. Although existing methods have identified many common drivers, it remains challenging to …
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Linking germination traits of oilseed rape (<i>Brassica napus</i> L.) to DNA markers
… and other germination traits, and in underlying genetic heterogeneity. The aim of this work was to quantify in more detail inter- and intra- cultivar variation in germination traits for six oilseed rape cultivars, to confirm that variation was consistent in laboratory and field, and to ascertain …
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Functional analysis of A 5' untranslated variant in rhodopsin : implications for the retinitis pigmentosa phenotype
… loss of vision. Clinical, phenotypic and genetic heterogeneity are frequently observed in RP. Mutations in Rhodopsin (RHO) have been identified as a major cause of RP. A sequence variant identified in the 5' untranslated region of RHO, g.269A>G, also known as c.-26A>G, was proposed to …
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MOLECULAR DISSECTION OF CARDIOMYOPATHY
… are inherited cardiac conditions with marked genetic heterogeneity. The genetic aetiology of HCM and DCM in Singapore and European was broadly similar but Singapore Chinese HCM patients frequently have fewer clinically actionable disease variants, overall. Two common lowly penetrant risk …
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Population substructuring in Schreibers' long-fingered bat (Miniopterus schreibersii) in South Africa
… gene flow among colonies, resulting in genetically distinct breeding subpopulations. The population structure of M. schreibersii in South Africa was investigated using microsatellites and mitochondrial DNA (mtDNA), with the aim of determining the degree of genetic differentiation among …
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Exploring the role of aneuploidy in phenotypic variability
… These differences have long been attributed to genetic differences within the population altering the likelihood that particular phenotypes will develop. However, work in yeast and mouse models of aneuploidy suggest that phenotypic variability can be a consequence of aneuploidy itself in the …
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Oncogene-induced remodelling of cellular networks
… stressors. During carcinogenesis, cells accrue genetic alterations that rewire signalling pathways, eventually leading to the partial loss of homeostatic control and cancer- related phenotypes. Cancer is a very heterogeneous disease with genetic alterations that exhibit vast variability within a …
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Epidemiology and comparative analysis of Yersinia in Ireland
… diarrhoea and domestic animals revealed high genetic heterogeneity of these species. Because of the extensive human, animal and food exchanges between the UK and Ireland the objective of this study was to gain further insight into genetic heterogeneity and relationships among clinical and …
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Oncogenic KRAS drives heterogeneity in metabolic and signalling pathways through genetic and non-genetic mechanisms
… research into PDAC and KRAS, the impact of both genetic and non-genetic variability during the earliest steps of carcinogenesis are scantly described. We hypothesise that both forms of heterogeneity might alter the efficiency of PDAC initiation. On the one hand, oncogenic KRAS alleles might …
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Emergent patterns of diversity and dynamics in natural populations of planktonic Vibrio bacteria
… environmental change. Fine-scale analysis of the genetic structure within one Vibrio population (>99% rRNA similarity to V. splendidus) reveals vast co-occurring genomic diversity. The average concentration of unique genome-types is observed to be 1000-fold lower than the total population size and …
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