Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"genetic drivers"”.
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Methods for inferring dynamical systems from biological data with applications to HIV latency and genetic drivers of aging
… fail for different reasons: inferring the genetic networks controlling aging across the human lifespan, and inferring the processes allowing latent HIV infection to persist and evade a cure with existing treatments.
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A Compendium of Genetic Drivers for Oesophageal Adenocarcinoma defines Prognostic and Therapeutic Biomarkers for use in the Clinic
… rapidly rising incidence. Understanding of the genetic events driving OAC development is limited, and there are few molecular biomarkers for prognostication or therapeutics. This study aimed to use a large cohort of genomically characterised OACs to determine the landscape of genetic driver …
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CHARACTERIZING THE ROLE OF THE CHROMATIN REMODELING COMPONENT ARID1A AS A SUPPRESSOR OF SPORADIC MAMMARY TUMORS IN MICE
… a significant amount of knowledge regarding the genetic drivers of hereditary breast cancers, there is very little known about the genes responsible for driving sporadic breast cancers, largely in part due to the dearth of appropriate mouse models of this disease. The C3H-MCM4Chaos3(Chaos3) mouse …
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Identification of genotype-specific dependencies in Keap1-deficient lung adenocarcinoma
… our ability to functionally interrogate putative genetic drivers in the context of mammalian cells and autochthonously arising tumors.
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Identification of novel gastric stem cell markers and investigation of Intestinal Stem Cell Cre-mediated Recombination
<p>Very few genetic markers for gastric stem cells are currently described. Identifying new markers is important for increasing our basic understanding of gastric tissues and studying mechanisms of cancer development. Gastric and intestinal tissues share a common developmental program. Thus, …
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Application of the single cell genomics in deciphering tumor heterogeneity and its role in tumor progression and drug resistance
… tumor progression, cancer cells acquire new genetic mutations, becoming more heterogeneous, leading to tumor progression and resistance to therapy. However, clear genetic drivers of progression, metastasis, and therapeutic resistance are identified in only a subset of tumors, pointing to …
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Modeling Recurrent Metastatic Events
… understood. Here, we aim to characterize the genetic landscape of metastatic drivers to specific organ sites using large-scale tumor sequencing and medical record data. We propose and evaluate a recurrent event survival model that draws additional statistical power from patients with multiple …
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Wisp1 Is An Overexpressed Driver of Glioblastoma
… grim. There is a tremendous need to identify new genetic drivers which can serve as potential therapeutic targets. In order to find new drivers, we leveraged genomic datasets to conduct a context specific <em>in vivo</em> functional genomic screen of overexpressed and/or amplified genes in GBM. We …
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Defining and Targeting Epigenetic Rewiring During Tumor Progression
… cause of death among breast cancer patients. Epigenetic mechanisms are critical for regulation of gene expression and to facilitate appropriate responses to environmental cues. However, it is increasingly appreciated that epigenetic dysregulation directly promotes therapeutic resistance and tumor …
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Genetic dissection of EGFRvIII brain and spinal mouse gliomas through whole-exome sequencing and in vivo piggyBac mutagenesis forward genetic screening
… significant morbidity in children; however the genetics of these spinal gliomas is poorly understood. EGFRvIII is a common driver mutation in brain gliomas; it is unclear when this is acquired during glioma evolution and what its cooperative genetic drivers are. Here, we show that EGFRvIII …
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Consequences of avian parental incubation behavior for within-clutch variance in incubation temperature and offspring behavioral phenotypes
… crucial for understanding parental effects, non-genetic drivers of phenotypic variation, and how environmental changes affect avian populations. I used wood ducks (Aix sponsa) as a study species to investigate how factors (disturbance, clutch size, ambient temperature) that influence parental …
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NOVEL APPROACHES IN GENETIC VARIANT DISCOVERY AND CLASSIFICATION TACKLING UNSOLVED PROBLEMS IN CANCER CLINICAL GENOMICS
… did not previously show positivity for known MPN genetic drivers (“triple negative disease”). In the latter study, we found a high prevalence of mutations in a known cancer-associated gene, KMT2C. However, we noticed that KMT2C variants were highly dependent on the alignment algorithm used, due to …
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The Efficacy of Immunotherapy in Preventing Liver Cancer and the Role of Metabolic Zonation in Its Development
… models, chemically-induced models, and genetically-induced models. Within these categories, models differ in factors such as the source of the tumor cells and the chemicals or genetic drivers used to induce tumorigenesis. All of these models offer specific advantages over the others but …
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Preclinical Models to Identify Molecular Drivers of Metastasis in Paediatric Musculoskeletal Cancer
… over the last 20 years. Current knowledge of the genetic drivers controlling the progression of MS cancers is very limited. Osteosarcoma also affects dogs and the pathology and pathogenesis of the canine disease bares remarkable similarity to the human variant. In dogs and humans, lung metastasis …
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Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice
… In the work presented here, we identify sex and genetic (strain) differences in initial response and rapid tolerance to THC, the main psychoactive ingredient in cannabis, between highly genetically divergent inbred mouse strains—C57BL/6J (B6) and DBA/2J (D2). To identify variation in THC response …
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Exploring new methodologies to identify disease-associated variants in African populations through the integration of patient genotype data and clinical phenotypes derived from routine health data: A case study for Type 2 Diabetes Mellitus in patients in the Western Cape Province, South Africa
… Introduction There is poor knowledge on the genetic drivers of disease in African populations and this is largely driven by the limited data for human genomes from sub-Saharan Africa. While the costs of generating human genomic data have gone down significantly, they are still a barrier to …
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Population-Level Differences in Pinus monophylla Whole-Plant Seedling Strategies Under Varying Precipitation Pulses
… is facilitated by phenotypic plasticity or genetic drivers can help to identify ideal seed sources for P. monophylla regeneration and restoration. As climate change shifts the adaptive landscape, phenotypic plasticity and gene flow may allow for unassisted regeneration. However, strong local …
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Physiological mechanisms of yield improvement in historical U.S. soybean germplasm
… century with yield gains widely attributed to genetic advances and improved cultivars, as well as advances in farming technology and practice. Although soybean yields do not appear to be stagnating, the current rate of gain is insufficient to meet the United Nations target of doubling crop …
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Bioinformatic methods for the analysis of genetic variability and regulation
… data to address questions related to how cell's genetic and epigenetic makeups give rise to phenotypic traits and regulatory processes. We started analyzing the relationship between genetic information and phenotype. On one hand, we used DNA-seq to compare the genomes of two behaviorally …
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Expanding the toolbox for precision medicine with silicon photonic microring resonators and microfluidic technologies
… genomic technologies and therapies targeted to genetic drivers of disease have inspired an era of precision medicine. Obtaining molecular profiles of disease requires analyzing biological samples that present daunting analytical challenges with thousands of potentially interfering analytes, …
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