Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 102 for “"genetic determinants"”.
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Genetic determinants of NEIL2 transcription
… mutagenic agents at the beginning of the study. Genetic determinants that influence NEIL2 transcription, including cis-regulatory sequences and sequence polymorphisms, were unknown. We hypothesize that cis-regulatory sequences in the 5’ upstream region of NEIL2 regulate gene transcript levels and …
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Genetic Determinants of Junin Virus Attenuation
… and functional characterization of viral genetic factors implicated in JUNV pathogenesis or attenuation would significantly improve the understanding of the molecular mechanisms underlying AHF and facilitate the development of novel, effective and safe vaccines. To this end, an RNA …
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Genetic Determinants of Human Serum Sterol Levels
… serum levels of this sterol substrate. In the genetic linkage analysis, a SNP in CYP39A1 was strongly (P=2.1 x 10-27) correlated with serum 24-hydroxycholesterol levels. Expression analysis indicated that this SNP also decreased CYP39A1 enzyme activity. Together, these results illustrate that …
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Dissecting genetic determinants of transcription factor activity
… factor activity. The first study is to dissect genetic determinants of transcription factor activity in a segregating population. We exploit prior knowledge about the in vitro DNA-binding specificity of a TF in order to map the loci (`aQTLs') whose inheritance modulates its protein-level …
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Genetic determinants of cognitive heterogeneity in Parkinson’s disease
… are unclear, however exploration of the genetic contribution to cognitive profiles is unearthing promising developments. This thesis comprises three studies that use statistical analysis of individual differences to unravel the genetic contribution of genes central to alpha-synuclein …
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Antibiotic Resistance: Multi-Drug Profiles and Genetic Determinants.
… goal of the study was to identify isolates for genetic characterization using comparisons of susceptibility profiles. Isolates of <em>Moraxella catarrhalis</em> collected from July 1984 through 1994 were analyzed for β-lactamase production using a Cefinase disk assay.</p> <p>A multi-drug profile …
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Unraveling the genetic determinants of virulence in Cryptococcus neoformans
… specific factors, including C. neoformans genetic background. C. neoformans has three major lineages: VNI, VNII, and VNB. VNI and VNII are both clonal and globally distributed, with the vast majority of disease caused by VNI. VNB is highly diverse and regional; disease caused by VNB …
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Mechanisms and Genetic Determinants of Alphavirus Infection of Mosquito Vectors
… and their vector indicate that the primary viral determinants for successful infection of epizootic mosquito vector can be mapped to the E2 glycoprotein region. I hypothesized that in addition to the E2 glycoprotein, regions outside of the E2 glycoprotein determine successful infection by enzootic …
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Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
… acidosis. From these screens, we discovered that genetic depletion of acetyl-CoA carboxylase alpha (ACACA or ACC1) or ATP citrate lyase (ACLY) protected cancer cells from hypoxia-induced apoptosis. Furthermore, the loss of ACLY or ACC1 reduced the levels and activities of the oncogenic …
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Functional Investigation of Genetic Determinants of Red Blood Cell Traits
… studies (GWAS) have identified thousands of genetic loci associated with blood cell traits. However, the identification and interpretation of candidate causal variants and genes remain challenging. With increasing power to detect genetic associations, many loci reveal multiple statistically …
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Genetic determinants underlying rare diseases identified using next-generation sequencing technologies
… has accelerated discovery of disease-causing genetic variants and is showing numerous benefits for research and medicine. I describe the application of next-generation sequencing, namely LipidSeq™ ‒ a targeted resequencing panel for the identification of dyslipidemia-associated variants ‒ and …
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Genetic determinants of rates of cognitive decline in preclinical Alzheimer’s Disease
… of efficacy in clinical trials. A number of genetic variants have been associated with cognitive performance, however additional research needs to be conducted to accurately understand the influence that genetic variation has on cognition in preclinical AD. Aims Initially the aim of this …
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Genetic Determinants of Salmonella and Campylobacter Required for In Vitro Fitness
… worldwide. A comprehensive understanding of the genetic factors that increase the survival fitness of these foodborne pathogens will effectively help us formulate mitigation strategies without affecting the nutrition ecology. The objective of this study was to identify the genetic determinants of …
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Genetic Determinants of ABCB1 Promoter Activity and Their Effects on Environmental Exposure
… offer important information on the role of genetic variability on the activity of the ABCB1 promoter. These studies provide a detailed sequence information for the ABCB1 promoter haplotypes in a mixed ethnic/racial population and demonstrate the effects from an individual SNP are not always …
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Genetic Determinants of Obesity in Relation to Diet, Weight Gain and Mortality
… believed to be a result of interactions between genetic and environmental factors. In this thesis we investigated the role of dietary factors in modifying the genetic susceptibility to obesity (papers I to III), studied the association between genetic susceptibility to obesity and weight gain at …
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Genetic and non-genetic determinants of drug response in type 2 diabetes
… treatment failure. In addition to non-genetic factors, geneticfactors are thought to contribute to such variability. </p><p class="MsoNormal" style="text-align:justify;line-height:150%"><b>Aim</b>: This thesisattempts to investigate genetic and non-genetic factors underlying …
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The genetic determinants of cardiovascular disease in patients with type 2 diabetes
The aim of this thesis was to identify genetic determinants associated with cardiovascular disease. We developed and verified algorithms to identify Coronary artery disease (CAD) , ischaemic stroke (IS) and lower extremity arterial disease (LEAD) cases and controls from electronic medical record …
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