Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"genetic cross"”.
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The actin-binding protein Drebrin and its implications for Alzheimer's Disease using the model organism C. elegans
… causing peptide pan-neuronally and employing a genetic sub-stoichiometric labelling method to be able to follow the aggregation in vivo and in situ in a non-invasive manner. A second model, expressing human Drebrin pan-neuronally was generated to analyse Drebrin stability, localization and …
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Interaction of akirin and pannier during embryogenesis of Drosophila melanogaster
… In this study, we identified and analyzed the genetic interaction of <em>akirin </em>with the transcriptional GATA factor, <em>pannier</em>. Also, we verified whether two (a third region consisting of a combination of both intronic regions) highly conserved intronic regions of <em>akirin</em> …
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Linkage mapping and genetic analysis of Trypanosoma brucei
… of T.brucei is now available and the diploid genetic system has recently been demonstrated to be Mendelian. This opens up the possibility of using a classical genetic approach to identify genetic loci that determine important phenotypic traits in this parasite, such as host specificity, drug …
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PERPETUATION OF NON-GENETIC CHANGES AT A TRANSGENE LOCUS IN C. ELEGANS
… to reprogramming mechanisms that erase epigenetic information transmitted from the previous generation and as it develops, the organism goes through experiences that affect gene expression. Despite this, developmental processes give rise to nearly the same organism in the next generation, …
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Characterization of the sex chromosomes in spinach
… YY progeny. The YY genotype was verified by a genetic cross and a novel X-specific marker. Potential novel X-specific sequences were found by depth of coverage analysis comparing alignments of male and female sequences to an XX reference. Of the 19 candidates found by depth of coverage, only …
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Algorithms for regulatory network inference and experiment planning in systems biology
… arises in the context of planning large-scale genetic cross experiments that can be used to validate predictions of multigenic perturbations made by mathematical models. (i) I present CrossPlan, a novel methodology for systematically planning genetic crosses to make a set of target mutants from …
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The role of coordinated regulation and aromatic metabolites in activating the mar/sox/rob regulon of Escherichia coli
… has focused primarily on the role of acquired genetic elements contained in transposons and plasmids. In contrast to this view, many bacterial species are equipped with intrinsic mechanisms to survive exposure to a wide variety of antimicrobial compounds. This form of resistance is mediated …
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
… proteins have key roles in drug resistance across a variety of organisms — in *P. falciparum*, the spread of resistance to the antimalarial chloroquine in the 1950s and 60s is largely due to mutations in the Chloroquine Resistance Transporter (PfCRT). Variations in the ABC transporter …
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Gain-of-Function Mouse Models to Investigate Biological Roles of Prmt6
… Cre-inducible PRMT6 transgenic mice have been crossed with a mouse line expressing a Cre recombinase under a Keratin 5 (K5) promoter, as well as with a MMTV-Cre mouse line. I have conducted carcinogenesis studies with these mice. The K5-Cre crossed mice have been subjected to skin …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
… of NSCs in the brain, short developmental time, genetic tractability and wide variety of experimental tools make Drosophila an ideal model for investigating NSC behaviour. My project utilises single-cell transcriptomics to study two aspects of brain development: 1) the regulation of developmental …