Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"genetic components"”.
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Computational tools for engineering functionally improved genetic components and cellular factories
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Investigation of the genetic components of maternal infanticide in Sus Scrofa
The aim of this thesis was to investigate the genetic components of maternal infanticide in the domestic pig (Sus scrofa). The killing of piglets by sows by eating them soon after birth is a significant issue for the pig breeding industry because of the impact on animal welfare and the cost in lost …
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Identification of genetic markers associated with growth and morphology quality in senegalese sole (solea senegalensis) to boost aquaculture production
… to solve these problems but requires estimate genetic components of economically valuable traits such as those growth and morphology related under industrial conditions. By other side, the advances in genomics provide new highly powerful analysis tools to determine more accurately genetic …
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Estimation of gene network parameters from imaging cytometry data
Synthetic biology endeavors to forward engineer genetic circuits with novel function. A major inspiration for the field has been the enormous success in the engineering of digital electronic circuits over the past half century. This dissertation approaches synthetic biology from the perspective of …
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Positional Cloning of Adiposity Genes in Ethnic Minorities of the Insulin Resistance Atherosclerosis Family Study
… environment, lifestyle, and predisposing genetic variation. The known physiologic profile of visceral adipose tissue suggests that it could be responsible for obesity’s pathogenicity. Furthermore, African Americans and Hispanic Americans are at a disproportionately higher risk for obesity …
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ST3GAL3 GENE MUTATION WITHIN THE SINGULAR NUCLEOTIDE POLYMORPHISM, RS3952787, POTENTIALLY COULD PREDICT ATTENTION DEFICIT HYPERACTIVE DISORDER, ANXIETY, AND DEPRESSION
… disorder, and as such, certain genetic components may potentially aid in the diagnostic process. Previous and current literature has identified ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (<em>ST3GAL3</em>) as a highly probable genetic component underlying ADHD. This study …
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Quantitative genetic analysis of maize organogenesis
Uncovering the genetic architecture of complex maize phenotypes is a core goal in understanding fundamental genetics and plant breeding. Several characteristics of maize have made it a staple model organism for studying gene regulation and a global food source. Understanding the underlying genetics …
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Simulation, models, and refactoring of bacteriophage T7 gene expression
… molecular events given arbitrary arrangements of genetic components. This thesis is focused on constructing such models for gene expression during bacteriophage T7 infection. T7 gene expression is a particularly well suited model system because knowledge of how the phage functions is thought to be …
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Transcriptional Regulation of Shewanella oneidensis Using Native TMAO-Inducible Promoters in a Plasmid-Free System
… of increased EET activity. My work expands the genetic components that can be used to engineer S. oneidensis for use in biotechnological applications.
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EXPLORING THE CORRELATION OF THE PRESENCE OF THE ST3GAL3 GENE IN INDIVIDUALS DIAGNOSED WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER USING LOOP MEDIATED ISOTHERMAL AMPLIFICATION WITH COLORIMETRIC DETECTION
… can be considered a disorder with significant genetic components. More recent literature points towards the ST3GAL3 gene as a significant source for this genetic correlation. If ST3GAL3 gene plays a significant role in genetically linked ADHD, then we should be able to detect a normal ST3GAL3 …
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The Genetic Basis of Susceptibility to Therapy-related Leukemia in Mice
… chemotherapy drugs and has a poor prognosis. Genetic background influences the risk of acquiring t-AML, yet little is known about susceptibility factors. To identify candidate risk factors, cohorts of twenty inbred mouse strains were treated with N-ethyl-N-nitrosourea (ENU), a potent …
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Transcriptomics to gene expres[s]ion : analysis of the ontogeny of sexual dimorphism in a crustacean, Euphilomedes carcharodonta
<p>The genetics of switchback evolution is largely unknown. While it is assumed that latent gene regulatory networks become reactivated to recreate an ancestral tissue, the details regarding this reactivation has yet to be elucidated. How has a network been maintained over the evolutionary history …
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An Experimentally-validated Agent-based Model to Study the Emergent Behavior of Bacterial Communities
… can be used to predictively design synthetic genetic components towards programmed microbial behavior.
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Identification of new genes and pathways that act to delay C. elegans aging
… an organism is determined by both stochastic and genetic components. The importance of genes is illustrated by the discovery of single gene mutations that alter lifespans of species ranging from invertebrates C. elegans and D. melanogaster to mice. To better understand the mechanisms underlying …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… germline mutations in the bone morphogenetic protein receptor type II (BMPR2) have been linked with the majority (~75%) of the familial form of the disease (HPAH). Mutations in the BMPR2 gene impinge upon the BMP signalling which perturbs the balance between BMP and TGF-β pathways …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… germline mutations in the bone morphogenetic protein receptor type II (BMPR2) have been linked with the majority (~75%) of the familial form of the disease (HPAH). Mutations in the BMPR2 gene impinge upon the BMP signalling which perturbs the balance between BMP and TGF-β pathways …
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Biochemische und funktionelle Charakterisierung einer gerichteten Gendeletion (Knockout) von Fetuin-A in Mäusen
… -/- animals suggested that there are additional genetic components that contribute to the phenotype. The decreased magnesium concentration in the D2 strain could be one modulator because magnesium ions - as fetuin-A - can inhibit crystal growth.
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Molecular mechanisms of stress tolerance in plants
… Therefore, it is necessary to search for new genetic components and strategies for improving resistance and tolerance in crops. In the present thesis, we describe two different approaches that increase our understanding of mechanisms of stress tolerance in plants. The first approach is to …
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Family Histories of Mental Illness and Violence in State Patients
… both severe mental illness and violence have genetic components. Multiple genes play a role in the cause of violent behaviour. Violence is one of the leading causes of death for young people in South Africa and yet little is known about its prevalence in state patients and their family …
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