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Showing 1 to 20 of 70 for “"genetic characterization"”.
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Genetic characterization of Theobroma cacao L Nicaraguan
Genetic composition of Theobroma cacao L., including 60 Nicaraguan farmers accessions, was investigated using nine microsatellite (SSR) markers. Fourteen breeders accessions from Experimental Center “El Recreo”, INTA, Nicaragua, two Criollos accession from CATIE, Costa Rica, and two accessions from …
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Genetic Characterization of Zambian Native Cattle Breeds
Breed characterization is a primary step in designing appropriate management and conservation programs of livestock in developing countries. Since cattle represent a major food animal species in Zambia, its conservation is a major goal for both the government and non-governmental organizations. To …
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Genetic characterization of families with von Willebrand disease
… to how it is manifested and inherited. The genetics of, especially type 1, VWD is relatively complicated and many aspects of it remain to be elucidated. The purpose of these studies was therefore to investigate and clarify certain genetic mechanisms that underlie VWD. When we investigated to …
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Genetic Characterization and Manipulation of Solvent -Producing Clostridia
The sol operons from Clostridium beijerinckii NCIMB 8052 and C. beijerinckii BA101 were cloned and sequenced to determine if differences at the sequence level were responsible for the increased butanol production exhibited by C. beijerinckii BA101 relative to the wild type C. beijerinckii NCMIB …
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Molecular genetic characterization of the Drosophila synaptotagmin family
Proper functioning of the nervous system requires fast, spatially-restricted neuron- neuron communication at synapses. Classic physiology studies have demonstrated the importance of calcium in regulating synaptic communication; however the molecular events underlying basic synaptic transmission and …
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Bacteriophage Felix O1: Genetic Characterization and Bioremedial Application
Bacteriophage Felix O1 was studied for applicability as a Salmonella intervention. Felix O1's potential as a Salmonella therapeutic was explored, as was its utility as a food application. Felix O1 is specific for and infects most serovars within the genus Salmonella. The entire 86.155-kb sequence …
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Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia
The aim of my thesis has been to characterize genetically pediatric T-cell acute lymphoblastic leukemia (T-ALL). Articles I and II focus on molecular characterization of translocations involving T-cell receptor (TCR) loci. These types of aberration are characteristic for T-ALL and have previously …
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Strategies for the genetic characterization of the oral streptococci
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Genetic characterization of human immunodeficiency virus from Northern South Africa
… significant opportunities for the spread of new genetic subtypes and/or evolution of current subtypes. Furthermore, analysis should therefore focus on areas where little information is known, such as the Limpopo Province, and where the opportunity for the introduction of new variants exists, and …
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Molecular and genetic characterization of spinocerebellar ataxia type 5 (SCA5)
… are a novel cause of ataxia and the continued characterization of these mutations will lead to a better understanding of the pathogenic mechanisms underlying SCA5 and neurodegenerative disease in general.
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Genetic characterization of the mucopolysaccharide utilization system of Bacteroides thetaiotaomicron
… To address this question, I have taken a genetic approach investigating the mechanism of host-derived mucopolysaccharide utilization and determining the importance of mucopolysaccharides for the survival of Bacteroides in the human colon.
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Molecular genetic characterization of ataxic movement disorders in mouse and human
… approaches are insufficient. The data suggest genetic alterations at ITPR1 underlie approximately over 1% of autosomal dominant SCA type III (ADCA III) cases for which currently no genetic cause has been identified. Data described herein add weight to a role for aberrant intracellular Ca2+ …
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Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis
… higher age. The presence of specific acquired genetic abnormalities is important for diagnosis, prognostication, and treatment stratification. ALL can be further categorized into subgroups defined by structural or ploidy abnormalities. One such subgroup, hypodiploid ALL (<46 chromosomes) is …
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Biochemical and genetic characterization of U1 and U3snRNAs from Schizosaccharomyces pombe
I have examined the small RNA profile of the fission yeast Schizosaccharomyces pombe. In vivo labeling followed by two dimensional gel electrophoresis of S. pombe RNA demonstrates the presence of four prominent species in the size range of interest (100-300 nucleotides). Further analysis of these …
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Molecular genetic characterization of two solvent pathway dehydrogenases from Clostridium Acetobutylicum
… forms part of a wider research effort into the genetics and molecular biology of C. acetobutylicum, which has as an ultimate goal the commercial improvement, and a fundamental understanding of the ABE fermentation. The aim of this study was to isolate and characterize genes involved in …
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Genetic Characterization and Linkage Mapping of Barley Net Blotch Resistance Genes
… resistance sources is dependent upon successful characterization of genes governing resistance in each resistant parent. Five net blotch resistant parents and one susceptible parent were crossed to identify novel resistance genes, postulate gene number and mode of inheritance, and conduct linkage …
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RARE BLEEDING DISORDERS: INSIGHTS INTO CLINICAL PRESENTATION, LABORATORY PHENOTYPE, AND GENETIC CHARACTERIZATION
… Questa tesi integra analisi genetiche, valutazioni cliniche standardizzate e fenotipizzazione di laboratorio, contribuendo a un significativo avanzamento nel campo. (I) Nel primo capitolo abbiamo analizzato genotipo e fenotipo di laboratorio di 526 casi di RBD, una delle …
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Biochemical and Genetic Characterization of Reduced Phosphorus Metabolism in Pseudomonas Stutzeri WM88
The first detailed biochemical and genetic analysis of reduced P metabolism in microorganisms is described in this thesis. Pseudomonas stutzeri WM88 is able to oxidize hypophosphite (P valence +1) and phosphite (P valence +3) for their use as the sole source of P. This process requires two operons …
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Genetic characterization of a family of mouse 5-methylcytosine binding protein genes
Cytosine-5-methylation has been associated with repression of transcription across eukaryotic phyla. In mammals, defects in methylation are associated with disease, developmental defects, and lethality. Furthermore, methylcytosine-specific binding proteins have been described which seem to effect …
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