Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"genetic changes"”.
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Genetic changes in the development of multiple myeloma
… only occurs in ~1% of patients per year. From a genetic point of view, specific abnormalities represent initiating events (i.e. IgH translocations or hyperdiploidy) of this multistep process while others occur at later stages. In this study, interphase-FISH showed that initiating events are …
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PERPETUATION OF NON-GENETIC CHANGES AT A TRANSGENE LOCUS IN C. ELEGANS
… to reprogramming mechanisms that erase epigenetic information transmitted from the previous generation and as it develops, the organism goes through experiences that affect gene expression. Despite this, developmental processes give rise to nearly the same organism in the next generation, …
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Genetic Changes in Pseudorabies Virus After Passage in Captured, Wild Mus Musclulus Domesticus
… to determine if Mus could be vaccinated with a genetically modified strain, and if the vaccine could be shed from these mice after challenge with a more virulent strain. Further, dosage conditions that promoted viral recombination in this host and characterization of these recombinants were also …
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Yearly Environmental and Genetic Changes in the Yield of Fat Corrected Milk Within a Dairy Herd From 1901 to 1954
Made available in DSpace on 2014-12-05T23:07:51Z (GMT). No. of bitstreams: 1 0016388.pdf: 2927513 bytes, checksum: 719ddfd3a870c2263f098e20ebc48127 (MD5) Previous issue date: 1956
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Determining the Fate of Hybridized Genomes in the Allopolyploid Brassica napus
… challenges to fertility following hybridization. Genetic changes in allopolyploids result from recombination between the hybridized subgenomes, which can influence phenotype and ultimately determine fitness of future generations. To study dynamic changes that follow allopolyploid formation, …
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Evolution and Genetics of Floral Color Polymorphisms in Clarkia gracilis ssp. sonomensis and Erythronium umbilicatum
… are pervasive in nature. Understanding the genetic basis of such polymorphisms allows us to address major evolutionary questions including: what types of genetic changes contribute to the evolution of phenotypic diversification? Have they arisen from new or pre-existing genetic material? And …
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IKAROS and LEUKEMIA
… morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct subtypes. Proper classification is important because determining the correct subtype plays a vital role for prognostication and treatment strategy. During the last decades, the use …
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Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia
… for leukemia to arise. Hence, the additional genetic changes present in leukemic ETV6/RUNX1-positive cells give important clues regarding the history of the leukemia. The aim of this thesis has been to characterize thoroughly the genetic changes present in ETV6/RUNX1-positive ALL. In Article …
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Oncogene-Induced Signaling Heterogeneity in Lung Cancer
… novel therapeutic targets. Although studies on genetic heterogeneity in subclonal populations within one tumor using deep sequencing and multiple sectioning have gained popularity recently, the signaling heterogeneity within tumor cells with identical genetic changes remain poorly understood. …
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Trisomies in Hematologic Malignancies
… is known about the biologic outcome, the pathogenetic significance, or the mechanism behind the formation of the latter genetic changes. The aim of the present thesis was to address these issues, focusing on trisomy 8 as the sole cytogenetic change in acute myeloid leukemia (AML) and …
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Tracking buffers of mutation and noise to the genome
Phenotypes are buffered from both genetic perturbations and developmental noise; however, the mechanisms by which this buffering occurs and its evolutionary relevance are poorly understood. In this dissertation, a combination of genetic and computational approaches were undertaken to not only …
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PTEN loss induces epithelial-mesenchymal transition in human colon cancer cells
… tumor milieu likely act in concert with genetic changes in the tumor cells and contribute to enhanced tumor invasion.
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Automated liquid dispensing pin for DNA microarray applications
… the system necessary to help detect and study genetic changes in cells in a more efficient and cost effective manner.
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Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice
… between misaligned sequences can lead to loss of genetic information (e.g. deletions, translocations and loss of heterozygosity). Given that such genetic changes may promote tumorigenesis, it is critical to identify those genetic and environmental factors that render cells susceptible to …
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The genetics of mycolic acids biosynthesis in Corynebacterium glutamicum
… of C. glutamicum. Secondly, investigating the genetics of mycolic acids biosynthesis. This involved identification of presumptive inhA gene involved in mycotic acid synthesis using various molecular biology approaches in C. glutamicum and Brevibacterium species, sequencing the inhA gene in …
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Genetic and Evolutionary Analyses of Drosophila Melanogaster Divergently Selected for Geotaxis
… movement with respect to gravity), that involves genetic analyses and changes in selection pressure. The extreme geotactic expressions observed in the negatively geotactic (high) and positively geotactic (low) lines were considered to be examples of instinctive behavior because (1) they seemed to …
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Molecular evolutionary analysis of the American pika (Ochotona princeps)
… are an excellent system to use for detecting genetic changes associated with adaptation to these conditions. American pika populations were located at lower elevations during glacials, and shifted upslope during interglacials. In this scenario, pikas would have experienced increased selective …
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Étude paléogénétique du cerf élaphe (Cervus elaphus) au cours de la transition Tardiglaciaire - Holocène ancien du Jura (15 000 – 6 000 BP) : relations entre changements morphologiques, environnementaux et génétiques
… to decrease. To complete both studies, a palaeogenetic approach was then developed to test two different alternative: do the deers found come from a single population that adapts to new ecological conditions or instead do they correspond to a succession of different populations depending on …
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Investigating the Fate of Pre-neoplastic Cells in a Mouse Model of Medulloblastoma
… cells that do not form tumors remains unknown. Genetic fate mapping and orthotopic transplantation provided definitive evidence that PNCs give rise to tumors and showed that the predominant fate of PNCs that do not form tumors is differentiation. Moreover, N-myc, a gene commonly amplified in …
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Genetic variability and differentiation in niche components of marine phytoplankton species
… The data were used to determine the amount of genetic variability and the spatial patterns of genetic differentiation in these species. None of the species examined exist purely as clones in nature. Statistically significant genetic variability is found even among clones isolated from single …
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