Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"genetic ancestry"”.
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Genetic ancestry and population health: elucidating the relative role of African genetic ancestry in cancer genomics and the broader implications for racial health disparities in cancer
… Among these groups, individuals of African ancestry, particularly African Americans, face some of the most severe outcomes, including higher incidence rates, delayed diagnoses, poorer prognoses, reduced survival, and less effective responses to treatment. While historical and systemic …
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Ancestral Paths: Redefining local genetic ancestry and its inference with application to Europeans
… genomes which gives us a snapshot of past genetic variation. We can therefore make inferences from observed genetic signatures present before historical events such as population bottlenecks and natural selection have obscured them from the modern gene pool. Ancient DNA has thus revealed …
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THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES
Background: Genetic studies in asthma and COPD have identified common genetic variants that explain a small proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such …
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Racial Becoming: How Agentic (Self-Initiated) Encounter Events Inform Racial Identity Refinement
… In the context of this study, direct to consumer genetic ancestry tests (DTC-GAT) are operationalized as a self-initiated encounter event. Participants were enrolled in an arts-in-education program that connects self-identified Black Americans with their ancestral roots through theater and genetic …
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Force-extension of the Amylose Polysaccharide
… of South African MG patients of African genetic ancestry develop immunosuppressive therapy-resistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury. Sequence analysis …
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Genetic and Clinical Determinants of Racial/Ethnic Differences In Multiple Myeloma Susceptibility and Outcomes Focusing On Hispanics
… phenotype are also present for MM patients by ancestry, including varying rates of common initiation mutations such as IgH translocations and TP53 mutation between patients of European and African descent. Studies have begun to interrogate the genetic basis for differences in MM susceptibility …
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Motor neuron disease in an African population: A review of current literature and a case series of the flail arm variant in the Western Cape
… on motor neuron disease in persons of African genetic descent, and to describe the clinical phenotype in a subgroup of MND patients with the flail arm (FA) variant seen at Groote Schuur Hospital MND clinic. Methods: In order to identify the current published knowledge of motor neuron disease in …
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Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis
… of South African MG patients of African genetic ancestry develop immunosuppressive therapyresistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury.
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Studies on Host-Seeking Behavior and Differential Chemosensory Gene Expression in Above- and Below-ground Culex Pipiens
… in nature. I characterized the behavioral and genetic variation across eight populations collected from above- and below-ground habitats. Three of the five above-ground populations had hybrid ancestry in our single locus assay, whereas the below-ground populations did not. In choice tests, four …
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Ancestry-based Methods for Characterizing the Evolutionary History of Admixed Populations
… come together to form a new population with genetic ancestry from those sources. Admixture is ubiquitous across the tree of life, including humans, and is often associated with migration and exposure to new environments and selective pressures. Admixed populations provide a unique opportunity …
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Psychological trauma and posttraumatic stress disorder in a South African birth cohort study
… PTSD, are likely to include environmental and genetic influences. Given the high burden of trauma and related disorders, the unique genetic ancestry, and the relative paucity of empirical data, further work in South African populations is warranted. This thesis aimed to investigate a number of …
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A modular and adjustable ptosis crutch as a non-surgical solution to elevating the upper eyelid of myasthenia gravis patients
… the eye and facial muscles. Patients of African genetic ancestry, particularly juveniles, are more likely to develop ocular muscle complications of MG compared to their European counterparts. MG ophthalmoplegic complications include persistent difficulty with moving the eyes and blepharoptosis, …
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The genetic heritage of China: A genomic study of PR China based on nine representative ethnic populations
During the course of the last decade, genetic data have increasingly complemented linguistic, archaeological and palaeontological evidence in efforts to reconstruct human history. As technology has developed, studies have utilised genomic techniques in tracing the origins and migratory patterns of …
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Genomic insights into the evolution of the parasitoid Microctonus aethiopoides
… populations. The study reveals two distinct genetic clusters, most likely reflecting the genetic ancestry of introduced populations rather than post-introduction geographic isolation. All populations exhibit very low diversity and limited population expansion since release, consistent with …
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Investigating the functionality of candidate susceptibility genes in ophthalmoplegic myasthenia gravis using patient-derived material
… OP-MG predominantly affects patients of African genetic ancestry and most commonly those with juvenile-onset. The cause of OP-MG is unknown. Previously, in efforts to understand the pathophysiology of this subphenotype, whole-exome sequencing was undertaken which identified amongst others a …
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
… of South African MG patients of African genetic ancestry develop a severe extraocular muscle (EOM) phenotype whilst receiving standard immunosuppressive drug therapies. This phenotype associates with a functional c.-198C>G SNP (C>G SNP) in the regulatory region of decay accelerating …
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Investigating the functionality of African-specific variants in the TGFB1 regulatory region and their potential role in HIV-associated kidney complications
… frequencies in South Africans with African-genetic ancestry (≈17%) compared with West and East African genomes (<5%). However, the functional significance of these SNPs has only been partially explored. In this study it was hypothesized that higher frequencies of immunemediated disease …
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A multi-ancestry genetic analysis of type 2 diabetes
… including diet, obesity, activity measures, and genetics. Over the past century, there have been extensive research efforts to describe the regulation of insulin secretion and downstream mechanisms of action, leading to the development of several efficacious therapies. Yet, despite these …
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Creating sense from non-sense DNA: de novo genesis and evolutionary history of antifreeze glycoprotein gene in northern cod fishes (gadidae)
… the fish. How and from where this important new genetic trait evolved in the gadid genome remained unknown, as thus far there are no homologous sequences in databases to infer genetic ancestry based on sequence homology. Additionally, the seven AFGP-bearing species are dispersed in separate …