Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 400 for “"genetic analysis"”.
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Genetic Analysis of Macular Telangiectasia
… The goal of this work has been to identify a genetic cause for the disease in these families. To that end, I used genotyping data from approximately 900,000 single nucleotide polymorphism per individual to create sets of genetic markers for linkage analysis. I analyzed these markers using …
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Genetic analysis of thymocyte apoptosis
… in this GR-dependent system, a somatic cell genetic approach was taken. A panel of Dexamethasone (Dex)-resistant cell lines (Apt-) isolated in a previous study were characterized with respect to their sensitivity to GR-independent apoptotic signals. While W7.2 cells were sensitive to …
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Genetic analysis of hoof traits
… from University of Illinois dairy farm for genetic analysis were all inside 80% range of reference herds. Estimated heritabilities based on Snell transformed scores were.05,.12,.06,.14,.02 and.08 for corkscrew claw, heel erosion, interdigital dermatitis, laminitis, sole ulcers and white line …
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Interactive pedigree plotter for genetic analysis
… other relatives. It is often used to look at the genetic transmission of genetic disorders. The purpose of a pedigree is to have a visually easy-to-read chart that depicts a certain characteristic or disorder in a family. It can be used for a physical characteristic like having a widow‘s peak or …
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Quantitative genetic analysis of maize organogenesis
Uncovering the genetic architecture of complex maize phenotypes is a core goal in understanding fundamental genetics and plant breeding. Several characteristics of maize have made it a staple model organism for studying gene regulation and a global food source. Understanding the underlying genetics …
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Genetic Analysis of Drosophila Stomatogastric Nervous System
… of the ENS and with the fly's powerful genetics offers the opportunity to shed light on the molecular and cellular mechanisms functioning in ENS development. Ret gene expression is conserved in the migrating neural precursors and we have found Dscam protein is present in the axonal …
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Genetic Analysis of Adipose Lineage and Development
… development in vivo because of the lack of genetic tools. To this end, I generated a few knock-in mice that offer both spatial and temporal controls to manipulate gene expression in adipose tissues. Here I demonstrate the application of one of the tools, PPARgamma tTA, in exploring some …
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Genetic Analysis of Rna Exosome Complex Cofactors
<p>The RNA exosome complex is known to process and/or degrade many classes of RNA, including mRNA, rRNA, tRNA and snRNA, through its 3’-to-5’ exoribonuclease catalytic activity. The RNA exosome complex comprises a 9-unit core (exo-9), with six proteins making up a PH-Ring barrel and three proteins …
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Genetic Analysis of Variation in Neuron Number
… variation in neuron number results from both non-genetic and genetic factors. Non-genetic factors, such as litter size and parity, and genetic cofactors, such as sex, age, and body weight, can influence neuron number. However, the cumulative variance in neuron number that can be explained by the …
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Improving Genetic Analysis with Augmented Experimental Designs
<p>Genetic analysis aims at providing useful genetic information that can be used in plant or animal improvement. Genetic data are obtained from measuring traits in field experiments. One of the common problems associated with the field experiments is the field variation due to the heterogeneity of …
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Genetic Analysis of Taste in Homo Sapiens
… obtained from 60 individuals were performed and analysis of TAS2R38, Gustin, and TRPM5 variations were conducted through Polymerase Chain Reaction (PCR), sequencing for SNPs, and upQMPSF for CNV analysis of TRPM5. Among the SNPs and CNVs studied, only TAS2R38 was found to be significantly …
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Genetic analysis of Schizosaccharomyces pombe 7SL RNA
Signal recognition particle (SRP), a ribonucleoprotein composed of six polypeptides and one molecule of 7SL RNA, is required for translocation of secretory proteins into mammalian microsomal vesicles in vitro. In order to investigate the function of the RNA component of SRP, mutations were …
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Genetic analysis of longevity in Saccharomyces cerevisiae
… stress extends life span by a mechanism that genetically mimics CR supports this. High osmolarity causes a metabolic shift from fermentation to an NAD-generating glycerol biosynthesis pathway.
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Genetic analysis of Ximenia Americana under natural conditions
… hybridization approaches have been used for genetic analysis of species that do not have complete genome arrays available. The study used the cross-species DNA-DNA hybridization approach to characterize Ximenia americana biological processes. Preliminary micro-array studies done in the …
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Genetic analysis of the hl locus in maize
Several genetic factors determining the phenotype of maize (Zea mays L.) kernels have been identified and characterized through the analysis of mutant genotypes. The h1 locus is defined by a genetic mutation that results in a starchy and opaque endosperm. This study was conducted to determine the …
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Linkage mapping and genetic analysis of Trypanosoma brucei
… of T.brucei is now available and the diploid genetic system has recently been demonstrated to be Mendelian. This opens up the possibility of using a classical genetic approach to identify genetic loci that determine important phenotypic traits in this parasite, such as host specificity, drug …
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Genetic analysis of innate immunity in Caenorhabditis elegans
Pathogen resistance in Caenorhabditis elegans is a model for studying innate immunity. Several conserved activators in the p38 PMK-1 pathway have been identified and are required for pathogen resistance to the bacterium Pseudomonas aeroginosa. Thus far, screens have been performed to identify …
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Genetic Analysis of the Quorum Sensing Regulator EsaR
… complexes to EsaR. Hence, a random mutagenesis genetic approach to isolate EsaR* variants that are immune to the effects of AHL has been utilized. Error-prone PCR and site-directed mutagenesis were used to generate desired mutants, which were subsequently screened for their ability to repress …
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