Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"gene-environment interactions"”.
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Exploring Multivariate Gene-Environment Interactions: Models And Applications
… are driven by multiple risk factors, including genetic variants, environmental exposures and interactions between the two. The advent of GWAS in 2005 and subsequent methodological advances have increased our knowledge of the genetic risk factors underpinning complex diseases. In addition, some …
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Etiology of orofacial clefts, gene-environment interactions and folate
Contains fulltext : 146928.pdf (Publisher’s version ) (Open Access)
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Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
… (GST) are potent antioxidants. In this work, genetic polymorphisms that alter GST enzyme activity were genotyped in a family-based childhood asthma cohort (341 families, n = 1508) and analysed to investigate whether they alter the risk of developing asthma when individuals are exposed to …
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Using Genetic Epidemiologic Methods to Explore the Influence of Gene-Environment Interactions on Colorectal Adenoma Recurrence
… There is evidence to suggest that common genetic polymorphisms can modify the effect of environmental risk factors on colorectal neoplasia. Methods: Data on 1430 individuals were obtained from two chemoprevention trials, the Wheat Bran Fiber Trial (WBF) (1) and the Effects of …
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Investigating the role of ALDH3B2 and FUT2 as potential risk genes to colorectal cancer through computational analysis and gene expression study of colonic cells, and utilizing colorectal cancer cell lines to explore gene-environment interactions
… studies (TWAS) has brought to light numerous genetic loci known or predicted to be involved in conferring risk to various cancers. Using a systems genetics approach of GWAS and TWAS, this study sought to investigate two identified genes, ALDH3B2 and FUT2, in order to better understand their …
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Cortisol in Middle Childhood: Associations with Genetic Polymorphisms and Early Environmental Risk
… stress than others. The exploration of candidate genes and gene-environment interactions may be one promising window on risk versus resilience trajectories. However, prior work involving three polymorphisms (COMT Val158Met, MAOA-LPR, and 5-HTTLPR) has yielded well publicized but inconsistently …
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Robust numerical methods to solve differential equations arising in cancer modeling
… is a complex disease that involves a sequence of gene-environment interactions in a progressive process that cannot occur without dysfunction in multiple systems. From a mathematical point of view, the sequence of gene-environment interactions often leads to mathematical models which are hard to …
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Self-injurious and aggressive behaviour in Angelman, Cri du Chat and Cornelia de Lange syndromes
… behavioural phenotype to challenging behaviour (gene-environment interactions). Next, the phenomenology and correlates of self-injurious and aggressive behaviour in the syndromes were explored at a given level of behavioural specificity. Results showed that self-injury was more common in Cornelia …
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Exploring a Role for the Parkinson Disease-Linked GBA1 Gene in Host Responses to Infections
… arises from a combination of factors including genetics, environment, gene-environment interactions, sex and age. How these factors interact has yet to be elucidated. We have previously published roles for PD-linked genes in response to microbial infections in an effort to model gene-environment …
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The molecular genetics of bipolar affective disorder : South African populations, endophenotypes, and environmental influence
The identification of the genetic variants underpinning bipolar disorder (BPD) has been impeded by a complex pattern of inheritance that may include by genetic heterogeneity, genetic epistasis, gene-environment interactions, incomplete penetrance and variable expressivity. In this thesis three …
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Exploring Interactions Between DRD4 Genotype and Perceived Parenting Environment
This study examined possible interactions between DRD4 genotype and parenting on children’s externalizing, internalizing, and prosocial behaviors, and explored both parent and child perceptions of all variables. Both diathesis-stress and differential susceptibility hypotheses were assessed for …
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The impact of variation in the progesterone receptor gene, life history and lifestyle on endometrial function and the menstrual cycle
… by energetic models for fecundity that disregard genetic variation as a potential cause of differences in reproduction. Further, a strong correlation between ovarian and uterine markers of fecundity is assumed, although this assumption is not supported by the available data. A polymorphism in the …
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Bayesian Statistical Methods In Gene-Environment and Gene-Gene Interaction Studies
… diseases such as cancer result from multiple genetic changes and environmental exposures. Due to the rapid development of genotyping and sequencing technologies, we are now able to more accurately assess causal effects of many genetic and environmental factors. Genome-wide association studies …
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Global fibrinolytic potential of black South Africans in the North West Province
… of the plasminogen activator inhibitor-1 (PAI-1) gene on PAI-1act (activity) levels (a main determinant of CLT) and CLT, together with gene-environment interactions and the effect of urbanisation on these interactions. PARTICIPANTS AND METHODS Apparently healthy men and women between the ages of …
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Small RNA and A-to-I editing in Autism Spectrum Disorders
… and repetitive behavior. ASDs have a substantial genetic component, but the specific cause of most cases remains unknown. Understanding gene-environment interactions underlying ASD is essential for improving early diagnosis and identifying critical targets for intervention and prevention. Towards …
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Genetic dissection of variability in cognitive and locomotor phenotypes using Drosophila melanogaster
… by multiple factors including genomic makeup, environmental factors, and gene-environment interactions, therefore are considered complex multifactorial traits. Due to these many factors there is often variability in phenotypic presentation between individuals. While variation plays a critical …
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Novel cardiovascular risk factors in childhood
… dysfunction (Study II-III); exposure to environmental tobacco smoke (ETS) affects heart rate variability (HRV), and whether this association is influenced by diabetes-risk HLA (Study IV). The aim of study V was to investigate in an animal model susceptible to vascular disease whether …
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On the Cellular Basis of Hydrogen Sulfide Toxicity
… to chronic disorders that are dependent on gene-environment interactions. Clinical and epidemiologic studies reveal either persistent sulfate-reducing bacteria colonization or higher H2S concentrations in the gut or feces of patients suffering from ulcerative colitis and/or colorectal …
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Are maternal symptoms of depression/PTSD and Child Genetic risk scores for depression/PTSD associated with childhood subcortical brain volumes?
The antenatal period is a critical window for genetic and environmental factors to influence a child's brain development. While previous research in East Asian and European populations has linked child polygenic risk scores (PRSs) for depression and maternal antenatal symptoms (E) to child …
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