Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"gene-environment interaction"”.
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Investigating the role of ALDH3B2 and FUT2 as potential risk genes to colorectal cancer through computational analysis and gene expression study of colonic cells, and utilizing colorectal cancer cell lines to explore gene-environment interactions
… studies (TWAS) has brought to light numerous genetic loci known or predicted to be involved in conferring risk to various cancers. Using a systems genetics approach of GWAS and TWAS, this study sought to investigate two identified genes, ALDH3B2 and FUT2, in order to better understand their …
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Parenting styles in relation to body weight and smoking and drinking in children and adolescents: a longitudinal twin study
Objectives: Family provides an environmental and emotional context for children’s development and significantly influences children’s health across their life course. Given the prevalence of childhood obesity and deviant behaviors, parenting styles, which are potentially modifiable by …
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Genetic and environmental influences on impulsivity and coping motives for alcohol across emerging and young adulthood
Variation in the gene encoding the dopamine D4 receptor (DRD4) may moderate the influence of environments (i.e., a gene-environment interaction, GXE) on personality traits and motives associated with alcohol use disorders. This project examines whether variation in DRD4 moderates the environmental …
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Bayesian Statistical Methods In Gene-Environment and Gene-Gene Interaction Studies
… diseases such as cancer result from multiple genetic changes and environmental exposures. Due to the rapid development of genotyping and sequencing technologies, we are now able to more accurately assess causal effects of many genetic and environmental factors. Genome-wide association studies …
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Integrating Functional Genomics, Proteomics and Computational Analysis for the Characterization of Cellular Networks
… study of signaling pathways. I have developed a generalized method for the analysis of functional organization in complex networks. This method makes use of several novel metrics used to characterize a node's status in the network. After the nodes are clustered according to their characteristics, …
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Genetics of Experience: Genetically Sensitive Approaches to Measuring Childhood Environment
Environmental experience is not free of genetic influence. Through genetically-influenced behaviours, genes can influence exposure to certain environments: gene-environment correlation. Particular genotypes may also be more or less sensitive to the effects of the environment: gene-environment …
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Ethanol-induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome
… in one of the DNA mismatch repair (MMR) genes, such as MSH2. MMR is a DNA damage repair pathway involved in the removal of base mismatches and insertion/deletion loops, caused by several endogenous and exogenous factors. Loss of MMR through somatic alteration of the wild-type MMR allele …
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Adolescent inattention/overactivity/impulsivity as an outcome of early institutional deprivation: the role of genetic factors
… early deprivation is moderated by individual genetic make-up, using a subsample of 129 children. Candidate genes were selected using two strategies (Moffitt et al., 2005): i) a phenotype-based strategy that employed genes implicated in the aetiology of ADHD (dopamine transporter and receptor …
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Bayesian regularized quantile mixed models for longitudinal studies
… correlations in the presence of data heterogeneity and long tailed distributions of the disease phenotype is challenging, especially in the context of high dimensional regressions. Here, we aim at developing novel Bayesian regularized quantile mixed effect models to tackle these challenges. …
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Interaction Effects between the Cumulative Genetic Score and Psychosocial Stressor on Drinking Urge and Attentional Bias for Alcohol: A Human Laboratory Study
… studies suggest that the effects of stressful environments on drinking behavior may differ as a function of diverse single monoamine genes regulating serotonin and dopamine neurotransmission. However, research has not utilized an experimental design to examine whether the monoamine genes …
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Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
… (GST) are potent antioxidants. In this work, genetic polymorphisms that alter GST enzyme activity were genotyped in a family-based childhood asthma cohort (341 families, n = 1508) and analysed to investigate whether they alter the risk of developing asthma when individuals are exposed to …
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Characterization of Alternaria alternata isolates causing brown spot of potatoes in South Africa
… not have any effect on pathogenicity and isolate genetic capability had no influence on radial growth of isolates. The combined isolate and light effect (gene-environment interaction), had significant influence on both radial growth and disease severity. The taxonomy of the genus Alternaria has …
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Machine Learning to Interrogate High-throughput Genomic Data: Theory and Applications
… which has attracted great recent interest. The interaction effects among risk factors, both genetic and environmental, are hypothesized to be one of the main missing heritability sources. Moreover, detection of multilocus interaction effect may also have great implications for revealing …
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A Preliminary Investigation into Orofacial Clefts in the Central and Western Regions of Saudi Arabia
… cleft (NSOFC) at birth and (II) investigate the genetic and environmental risk factors associated with NSOFC in infants attending government hospitals in the Western and Central Regions of Saudi Arabia. <br/>Material and methods: Two hundred and seventeen non-syndromic orofacial cleft (NSOFC) …
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A role for environmental epigenetics in the rapid diversification of East African cichlid fishes
Phenotypic plasticity via gene-environment interaction is a central feature of regulatory biology. By definition, phenotypic plasticity involves a change in gene regulation. These gene regulatory transitions are commonly mediated by an array of epigenetic mechanisms, which exert dynamic, …
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Leveraging the microbiome in host genome wide association studies
… has emerged as an effective method for detecting genetic polymorphisms associated with expressed phenotypes. Over the past decade, GWAS of human traits and diseases has revolutionized the field of complex disease genetics, identifying hundreds of genetic variants associated with several different …
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Nature and nurture on picky eating behavior in early childhood
Eating behavior in children is influenced by both genetic and environmental determinants. In the first two years of life, children develop food preferences and dietary habits as they transition from a milk-based diet to table foods. During this time, picky eating behavior often emerges as children …
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Examining Alcohol Dependence and Its Correlates From A Genetically Informative Perspective
… disciplines, including developmental psychology, genetic epidemiology, and molecular genetics, to achieve our current understanding of environmental and genetic risk factors for AD as well as its variable developmental trajectories. Nevertheless, there is still much to be learned in order to …
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LIPID-RELATED CORONARY RISK PROFILE IN SINGAPORE NEWBORNS : RACIAL AND MOLECULAR GENETIC ASPECTS
… ethnic Indians. Despite a common socio-economic environment for generations, the difference in CAD prevalence rates seen in these three ethnic groups was maintained and is probably inherent and related to ethnicity. Plasma lipid, lipoprotein, apolipoproteins and lipoprotein(a) [Lp(a)] levels have …
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Environmental variation and life-history evolution: experiments on Caenorhabditis remanei
… their phenotypes in response to changing environments. Many of these differences are known to be due to genetic changes. However, some of the differences between individuals will be due to phenotypic plasticity. Phenotypic plasticity is the property of a given genotype to produce different …