Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"gene-dosage effect"”.
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Transcriptional Regulation of an Extrachromosomal Gal7 Gene in Saccharomyces Cerevisiae (Yeast Plasmids, Regulatory Mutants, Over Expression)
… of cloned DNA fragments encoding the yeast GAL7 gene, yeast plasmid vectors, chromosomal gal7 deletion strains, and GAL regulatory mutants were used to characterize the in vitro transcription of the GAL7 gene on autonomously replicating plasmids. Normal expression of the plasmid born GAL7 gene …
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Driver genes associated to Broad Copy Number Aberrations in solid cancers
… the changes in transcript levels correlated to gene dosage. It is known that differences in transcripts dosage are among the common causes of cancer progression, especially when somatic chromosomal aberrations occur into the cells. The molecular mechanism linking them to cancerogenesis and their …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… Questi geni Over-UpT sono arricchiti di "Fitness Genes", molti dei quali coinvolti nell’inizio della traduzione e nella poliadenilazione dell'mRNA. In questa tesi, sono stati analizzati i profili genomici e trascrittomici dei geni correlati ai pathway Fitness-OverT, tra cui eIF2, eIF3, CSTF e …