Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"gene variations"”.
-
Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations
… in a sub-population of pipistrelles that are genetically more homogeneous. Since Toll-like receptors (TLRs) are an important element of the mammalian innate immune system, a PCR strategy was developed to isolate TLR4 and TLR2 genes from the pipistrelle bats (n=59). The TLR4 sequences were …
-
Exploring the role of mu opioid receptor (OPRM1) and CYP2B6 gene variations for methadone pharmacogenomics. Can these variations be used to advance toxicological interpretation post-mortem?.
… OPRM1 A118G and CYP2B6 T750C, G516T, and A785G variations and post-mortem methadone concentrations were investigated. The allele frequencies of OPRM1 and CYP2B6 variants were then studied in a control population of live non-methadone using subjects, to determine the prevalence and distribution …
-
Associations between gene variations and milk composition in New Zealand dairy cattle: A thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… index, which is used to estimate an animal’s genetic merit for production. In addition to quantity, the compositions of the milk fat and protein are also important quality determinants for milk processing, milk products, and the nutritional value of milk. Gene-markers are useful tools for …
-
Gene variations of FABP4, SCD, GH, and IGF1R and their associations with meat and carcass traits in sheep : A thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… marker-assisted selection. This method leverages genetic variations within candidate genes that influence production traits, guiding animal breeding efforts to enhance desired characteristics. Improvements in phenotypic traits, including meat quality, growth rate, and carcass composition, provide …
-
Recognizing Lynch Syndrome by DNA Mismatch Repair Deficiency
… cancers in particular, although tumorigenesis is thought to only commence upon losing the healthy allele. The clinical importance of identifying LS patients is reflected by the significantly increased cancer risk of LS mutation carriers and the effectiveness of LS associated cancer …
-
An investigation into the capabilities and affecting factors of isometric mid-thigh pull force production in elite youth soccer players.
… is also little evidence around the nature, or genetic influence on this variable in these populations. Greater knowledge on these areas would be beneficial to aid an understanding of performance and to plan practical interventions. Eight weeks of training for players in the under 9 (U9) through …
-
Deficiency in Parkinson's Disease risk gene CD38 as it relates to glial function: dysregulation of astrocyte genes and bioenergetics as a result of CD38 deficiency
… is the second most prevalent age-related neurodegenerative disease and currently affects over 8 million people worldwide. The primary features of PD include cognitive, behavioral, and motor function deficits induced primarily by the progressive loss of dopaminergic neurons within the substantia …
-
Assoziation von Genpolymorphismen der 5 flankierenden Region des Interleukin-10-Gens auf das Überleben oder die Remissionsrate beim aggressiven Non-Hodgkin-Lymphom
… Arbeit unterstützen die Hypothese, dass genetische Polymorphismen innerhalb der 5 flankierenden Region des IL-10-Gens mit prognostischen Faktoren assoziiert sind sowie auf eine schlechte Prognose des aggressiven NHL hinweisen können.
-
Onkogenomische Aspekte Zytokin-assoziierter Signaltransduktion
… führt. Im zweiten Teil der Arbeit konnten durch Genexpressionsanalysen Zielgene von STAT6 im cHL identifiziert und teilweise validiert werden. Unter diesen Genen sind vor allem der Transkriptionsfaktor IRF4, die IL-13-Rezeptoruntereinheit IL13Ra1, die Rezeptortyrosinkinase EphB1 und die …