Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"gene switch"”.
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Gene switches and their applications in eukaryotic systems
Gene switches, also known as transcription factors, are important components of genetic circuits, and they have wide utility in synthetic biology, gene therapy, and developmental biology. Small molecule inducible gene switches are especially valuable as they offer an easy way to regulate target …
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Cellular reprogramming in eukaryotes
… processes are controlled by a highly complex genetic and epigenetic network. Although much of this complexity is still unknown to us, we have nonetheless begun exploring, perturbing, and creating genetic circuits in cells. To truly understand and control a cell, we have to build it from …
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Transcription Factor Engineering: Tools and Applications
… in the biology of every organism. By controlling gene expression they regulate growth, development, metabolism, reproduction, signaling, and response to the environment. They have also provided the basis for many useful tools in molecular biology. The estrogen receptor alpha is one of the most …
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I. Design and synthesis of estrogen receptor gene switches. II. Design and synthesis of estrogen receptor ligands occupying an auxiliary binding pocket
… to near wild type activity and create a novel gene switch.
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Development of inducible transgenic mouse models for melanoma
… of melanoma aetiology mediated by N-Ras and PTEN genes. To achieve this, an inducible gene switch approach was employed exploiting the Cre/loxP recombinase system. This approach has the advantage of avoiding embryonic lethality and helps to minimise disease(s) in other tissue(s) that may interfere …
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Unraveling the role of the antifungal peptide AnAFP in Aspergillus niger through a systems biology perspective
… pattern correlates with the activation of genes associated with autophagy, nutrient recycling, and development. Consequently, it has been suggested that AnAFP may operate as a cannibalistic toxin, promoting programmed cell death and contributing to the progression of development, ultimately …