Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"gene structure"”.
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Honey bee behavioural evolution and itpr gene structure studies
… described in Chapter 2, I conducted an itpr gene characterisation, a highly expressed gene present in honey bee brain (Kamikouchi et al. 1998). A partial sequence of the A. mellifera itpr gene was obtained which comprised of 2, 091 bp and showed 62%, 60%, 33%, 56%, and 56% similarities …
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Meta State Generalized Hidden Markov Model for Eukaryotic Gene Structure Identification
Using a generalized-clique hidden Markov model (HMM) as the starting point for a eukaryotic gene finder, the objective here is to strengthen the signal information at the transitions between coding and non-coding (c/nc) regions. This is done by enlarging the primitive hidden states associated with …
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Antifreeze Glycoproteins of Two Unrelated Polar Fishes: Gene Structure, Organization and Evolution
… cods are also encoded by a family of polyprotein genes in which multiple AFGP coding sequences linked in tandem by small cleavable spacers Args or Arg-Ala-Ala-Arg's. However, the northern cod AFGP genes show no sequence identity with trypsinogen gene, indicating trypsinogen gene is not the …
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Gene structure, transcripts and transcriptional regulation of primate type II gonadotropin-releasing hormone receptors
Includes bibliographical references.
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The NADP-dependent glutamate dehydrogenase of Giardia lamblia: a study of function, gene structure, and expression
… protozoan parasite, but its location in the phylogenetic tree is at a critical and informative position. Characterization of its subcellular structure and rRNA sequences suggest that Giardia is one the most primitive eukaryotes known. Giardia has an anaerobic metabolism that uses a NADP-dependent …
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Analysis of maturation-specific genes in soybean seeds: Gene structure, desiccation induction and abscisic acid responsiveness
This study describes two maturation (Mat) genes which share some structural similarities with a special group of genes, whose expression can be induced by water stress and also by exogenous abscisic acid (ABA) application. Previous studies have identified a 31-kDa maturation polypeptide (MAT) which …
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Bioinformatic studies of small disulphide-rich proteins (SDPs)
… Disulphide bridges play crucial roles in the 3D structure, function and evolution of SDPs. The roles and patterns of disulphide bridges in SDPs were investigated using bioinformatic approaches. The systematic analyses suggested that cysteine signature can facilitate the detection of distantly …
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Molecular cloning, characterization, and expression of 3-hydroxy-3-methylglutaryl coenzyme a reductase gene from tomato
… encoding HMGR. The nucleic acid sequence and gene structure was determined. The tomato HMGR gene (HMG2) contains four exons separated by three introns and encodes a polypeptide of 602 amino acid residues (about 64,714 Da). Two membrane-spanning regions are contained in the NH₂-terminus of the …
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Gene identification using phylogenetic metrics with conditional random fields
… a comprehensive and accurate annotation of all genes encoded in the genome, providing the basis for understanding human variation, gene regulation, health and disease. Traditionally, the problem of computational gene prediction has been addressed using graphical probabilistic models of genomic …
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Comparative transcriptomics of long intergenic noncoding RNAs in Drosophila
… along different trajectories than protein-coding genes. Most studies of lincRNA evolution analyze evolution only at the sequence level without ascertaining whether the lincRNA is expressed. Over 2,000 lincRNAs (and counting) have already been identified in the classic model system Drosophila …
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Bioinformatics approaches to large scale genome comparison, including the identification of conserved noncoding regions
… pattern of genomic DNA reveals much about the structure and organization of genomes. REPuter is a bioinformatics tool that efficiently finds repeatitive substrings in large genomic sequences. The identification of repeats enables a wide range of biological interpretations. Here we describe how …
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Subcloning and regulation of a human intestinal sodium-phosphate cotransporter gene
… research was to explore the transporter gene(s) involved in the intestinal sodium-dependent phosphate absorption in human and to investigate the role of sodium-phosphate (NaPi) transporters in phosphate homeostatic regulation. The research was performed to test the hypothesis that the …
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Models of dynamic RNA regulation in mammalian cells
… RNA life cycle. I study the kinetics of a gene's RNA population with a model of its production and degradation, and generalize the system as an ensemble of genes. I further model genes as composite particles and study the regulation and kinetics of altering their internal structure. To …
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Human ceruloplasmin gene and cDNA
… coagulation cascade,suggesting that the three genes evolved from a common ancestral gene. Thereare two ceruloplasmin specific mRNA transcripts, 3.7 and 4.4 Kb, produced bythe liver. Expression of the gene is regulated transcriptionally and post-transcriptionally. The initial aim of this study …
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Characterization of chalcone synthase genes in red raspberry cultivar (rubus idaeus)
… was focused on investigation of the PKS genes that are an essential for the biosynthesis of anthocyanins. The aim of this thesis was to characterize the PKS/CHS gene regions within the three Bacterial Artificial Chromosome clones (BACs), which originated from the genome of the European …
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Molecular analysis of migratory plant-parasitic nematodes with a focus on plant cell wall modifying enzymes
… for their infection process. Most studies on genes encoding these so-called parasitism proteins were conducted on sedentary plant-parasitic nematodes which manipulate the plant to induce a specialized nematode feeding site. In this doctoral thesis parasitism genes of the less specialized …
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Investigating The Roles of The P63 Isoforms In The Microrna Biogenesis Pathway
… biological processes like development, tumorigenesis, metastasis and pluripotency. My thesis work has demonstrated roles for <em>p63, </em>a <em>p53</em> family member, in the upstream regulation of microRNA biogenesis. The <em>p63</em> gene has a complex gene structure and has multiple …
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Transcription of human-specific duplicate genes
In this work, I set out to characterize new genes contained specifically within the human genome but absent from any other, including our closest evolutionary cousins. Our interest in these genes is twofold: First, gene duplication is a fundamental process by which evolutionary innovations at the …
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Genetic mapping and molecular characterization of tbr1 mutant in Arabidopsis thaliana
… synthesis (Potikha and Delmer, 1995). The TBR gene was identified by recombinational mapping, candidate gene sequencing and molecular complementation using genomic cosmid clones, as well as a p35S:TBR genomic DNA construct, fully rescuing the mutant phenotype in both cases. The only mutant …
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Comparison of orthologs across multiple species by various strategies
… we can give an estimate of the conserved set of genes across mammals and correspondingly, find the species-specific sets of genes or functions. However, comparative genomics can be feasible only if a meaningful classification of genes exists. A natural way to do so is to delineate sets of …
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