Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"gene signatures"”.
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Regulation of cellular growth and identification of stromal gene signatures in breast cancer
… to identify specific RNA targets, we performed a gene expression analysis and detected a negative regulation of the peripheral myelin protein (PMP22) by the G3BP1 isoform. The previously reported growth suppressing effects by PMP22 was here verified in breast cancer cells and we could show that …
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Correlation Matrix Analysis Identifies Gene Signatures of Immune Cell Subsets and Their Interactions In Follicular Lymphoma
… (CMA) of publicly available FL whole-tumor gene expression profiling (GEP) data, we have identified signatures of immune cell subsets. Overall survival correlated most highly with a model using signatures of macrophages, T cells, and stroma, which was able to add significantly to existing …
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Gene Set Analysis of Post-Lactational Mammary Gland Involution Gene Signatures In Inflammatory and Triple Negative Breast Cancer
… involution period mimics wound healing and tumorigenesis like pathological conditions. This indicates that post-lactational involution may create the microenvironment that initiates the development of precancerous mammary cells and promotes the progression of precancerous cells into cancer cells. …
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Clustering of immune-mediated diseases using genomic data
… the biclusters was a bicluster recovering the genes that escape X-inactivation and a bicluster capturing type 1 interferon response, enriched for samples from patients with systemic lupus erythematosus. I found that whilst it is an advantage that biclustering has sufficient complexity to …
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Developmental Single-Cell RNA Sequencing in the Sea Urchin Species Lytechinus variegatus and Heliocidaris erythrogramma
… and differentiation of cell types occurs through gene regulatory networks, or circuits of nodes or genes that interact with and regulate each other’s DNA elements. However, what remains unclear is how a highly conserved developmental GRN can change over evolutionary time and how that can result in …
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Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
… which contributes to complex lung tumor heterogeneity allowing for drug resistance development. In this study, gene expression signatures of six GFRN oncogenes overexpressed in human mammary epithelial cells (HMECs) were generated to interrogate this pathway’s downstream crosstalk, beyond …
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Machine Learning Methods for Single Cell RNA-Sequencing Data to Improve Clinical Oncology
… oncology. It covers four key areas: identifying gene signatures and biomarkers in multiple myeloma, developing methods to account for somatic copy number variations in tumor samples, benchmarking large, pre-trained scRNA-seq foundation models, and creating a framework for predicting clinical …
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Single-Cell Lineage Tracing Of Cancer Metastasis
… capture of both transcriptional and phylogenetic information. Applying macsGESTALT to a mouse model of metastatic pancreatic cancer, we recover ~380,000 CRISPR target sites and reconstruct dissemination of ~28,000 single cells across multiple metastatic sites. We find cells occupy a …
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DIABETES MELLITUS AND THE DYSREGULATION OF ANGIOGENESIS IN TUBERCULOSIS
… disease and poorer treatment outcomes. Angiogenesis plays a key role in TB immunopathology by supporting mycobacterial survival within granulomas, whereas DM-associated oxidative stress impairs normal angiogenic processes. I hypothesized that disrupted angiogenic regulation underlies the …
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Branching out: how a planarian neoblast generates cellular diversity
The extraordinary regenerative capacity of planarians is derived from their large population of pluripotent stem cells called neoblasts. Neoblasts are a heterogenous population of stem cells that begin unspecified, but are rapidly specified within a single cell cycle and give rise to every cell in …
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Prostate cancer evolution employing artificial intelligence to enhance biomarker discovery
Prostate cancer is highly heterogeneous, with the potential for multifocality with phenotypically and genetically distinct tumour foci. Additionally, cellular heterogeneity has the ability to harbour phenotypically diverse cancer cell types. Prostate cancer needs to be explored across different …
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Identifying biological pathomechanisms of TTN-affected myopathies using RNA-Sequencing data
The TTN gene is composed of 364 exons (363 coding) and encodes for titin, the largest protein in nature. Pathogenic TTN variants result in a wide spectrum of skeletal muscle and cardiac disorders known as Titinopathies. These differ in inheritance patterns, onset age, disease course and severity. …
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Hypoxia Acts As An Environmental Cue For The Human Tissue-Resident Memory T-Cell Differentiation Program
… enrichment for endogenous human T<sub>RM</sub> gene signatures, including increased expression of adhesion molecules and decreased expression of genes involved in recirculation. Hypoxia and TGF-β1 synergized to produce a significantly larger population of T<sub>RM</sub> phenotype cells than …
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MOLECULAR PROFILING OF UROTHELIAL CARCINOMA
The general aim of this thesis was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression …
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Integration of Genome Scale Data for Identifying New Biomarkers in Colon Cancer: Integrated Analysis of Transcriptomics and Epigenomics Data from High Throughput Technologies in Order to Identifying New Biomarkers Genes for Personalised Targeted Therapies for Patients Suffering from Colon Cancer
… Our current knowledge of colorectal carcinogenesis indicates a multifactorial and multi-step process that involves various genetic alterations and several biological pathways. The identification of molecular markers with early diagnostic and precise clinical outcome in colon cancer is a …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… effect in increasing the immune infiltrate, angiogenesis, and enriching gene signatures of metabolism, extracellular matrix organization, and MAPK/AKT signaling. Altogether, these studies highlight the importance of targeting multiple aspects of the immune response against tumors, and provide a …
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Arid1a Haploinsufficiency Initiates Neural Crest Transformation in a Mouse Model of Mycn-driven Neuroblastoma
… in the chromatin remodeler and tumor suppressor gene (TSG) ARID1A. Additional causal studies supported ARID1A’s candidacy as a putative 1p36 TSG in MYCN-driven NBL. This study aimed to causally test Arid1a loss during Mycn-driven NBL initiation through the development of a mouse model of high …
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Developmental Patterning and Cell Fate Specification in the Mouse Colon
… form during embryonic development, they can be regenerated after complete degradation as a result of injury. In recent years, a close connection has been made between these two processes, with the identification of foetal-like gene signatures in injured colonic epithelium. Despite this, the cell …
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Beyond differential expression : methods and tools for mining the transcriptomic landscape of human tissue and disease
… experiments provide measurements of thousands of genes simultaneously, and offer a snapshot view of transcriptomic activity. With the rapid growth of public availability of transcriptomic data, there is increasing recognition that large sets of such data can be mined to better understand disease …
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Integrative Analysis of Omics Data In Adult Glioma and Other Tcga Cancers to Guide Precision Medicine
<p>Transcriptomic profiling and gene expression signatures have been widely applied as effective approaches for enhancing the molecular classification, diagnosis, prognosis or prediction of therapeutic response towards personalized therapy for cancer patients. Thanks to modern genome-wide profiling …
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