Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"gene response"”.
-
Noxious Cellular Injury Triggers an Oxidative Stress Gene Response
<p>Wound and regeneration involves a series of complex processes that can induce oxidative stress by elevating intracellular reactive oxygen species (ROS) levels. In this study, we used RNA-seq and qPCR to examine the molecular signature of Human Embryonic Kidney cells (HEK-293T) stimulated with …
-
Bioremediation of Trichloroethylene: Analysis of the Plant Gene Response to TCE and Characterization of a Novel TCE-Degrading Endophyte
… the first study was that certain detoxification genes such as cytochrome P450s (CYP), glutathione-S-transferases (GST), glycosyltransferases (UGT), and ATP-binding cassette (ABC) transporters are involved in TCE metabolism in poplar. The study found that poplar trees do have a genetic response to …
-
INHIBITION OF ACTIVITIES OF INDIVIDUAL SUBUNITS OF INTESTINAL MALTASE-GLUCOAMYLASE AND SUCRASE-ISOMALTASE BY DIETARY PHENOLIC COMPOUNDS FOR MODULATING GLUCOSE RELEASE AND GENE RESPONSE
… were the effects of some phenolic compounds on gene expression levels of MGAM and SI. The presence of phenolic compounds in mouse explants caused the generation of different molecular size forms of MGAM, but with no effects on overall maltase activity of the intestinal epithelium. Overall …
-
MECHANO-CHEMICAL FEEDBACK VIA CONTACT PERCOLATION REGULATES PHASE TRANSITION AND TRANSCRIPTIONAL STATE IN HETEROGENEOUS BREAST CANCER
… BC progression, and triggers an inflammatory gene response via cGAS/STING pathway and the acquisition of malignant traits. While prior studies used genetically homogeneous models, BC exhibits mechanical and genetic heterogeneity, which role in PT and BC progression is poorly understood. Here, …
-
Dynamic Modulation of an Immediate -Early Gene in the Songbird Forebrain
"In the nervous system, immediate-early gene (IEG) induction is observed following exposure to salient events. Although the function of IEGs is not fully understood, one prominent model suggests that they are needed to consolidate memories of the inducing event---a ""feed-back"" model. However, a …
-
The immunomodulatory effects of the garlic organosulfur compounds allicin and Z-ajoene in an in vitro murine model of LPS-induced inflammation
… world. Chronic inflammation facilitates tumourigenesis and cancer progression by providing an environment conducive to cancer. Dysregulation of the immune response, and particularly inflammation, is an important part of this process. Garlic (Allium sativum) has been used for centuries as both a …
-
MODELING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY USING PRIMARY AND PATIENT-DERIVED INDUCED PLURIPOTENT STEM CELLS
… Dystrophy (FSHD) is an autosomal dominant degenerative muscle disease with no cure or treatment. The genetic cause of FSHD is the reduction of the copy number of subtelomeric D4Z4 repeats at 4q35 encoding Double Homeobox 4 (DUX4) protein, which is a potent transcription factor that is toxic …
-
Isolation, characterisation and in vitro potential of Oogonial stem cells
… the cells has not been proven, they do appear to generate oocytes when cultured in specific environments, resulting in live offspring in rodents. The primary aim of this thesis was to verify independently the existence of OSCs in human ovary and determine whether they could be isolated from a …
-
Transcriptomic and Secretomic Profiling of Isolated Leukocytes Exposed to Alpha-Particle and Photon Radiation - Applications in Biodosimetry
The general public is at risk of ionising-radiation exposure. The development of high-throughput methods to triage exposures is warranted. Current biodosimetry techniques are low-throughput and encumbered by time and technical expertise. Although there has been an emergence of gene-profiling tools …
-
HPV pseudovirion production in plants
… further work is underway to develop a second generation HPV vaccine that is cheap, stable and displays cross-neutralising activity across a broader range of HPV types. The recent efficient methods for intracellular production of HPV PsVs encapsidating nonpapillomaviral DNA (pseudogenomes) has …