Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 152 for “"gene regulatory networks"”.
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Supervised Inference of Gene Regulatory Networks
A gene regulatory network (GRN) records the interactions among transcription factors and their target genes. GRNs are useful to study how transcription factors (TFs) control gene expression as cells transition between states during differentiation and development. Scientists usually construct GRNs …
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Robustness Analysis of Gene Regulatory Networks
Cells generally manage to maintain stable phenotypes in the face of widely varying environmental conditions. This fact is particularly surprising since the key step of gene expression is fundamentally a stochastic process. Many hypotheses have been suggested to explain this robustness. First, the …
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Gene Regulatory Networks in Striated Muscle Pathologies
… discs. Both these tissues partake in force generation through contractile units called sarcomeres to support movement, respiration (skeletal muscle), and to pump oxygenated blood throughout the body (cardiac muscle). Gene regulatory networks, the interactions between lineage or …
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Simulation and identification of gene regulatory networks
Gene regulatory networks are a well-established model to represent the functioning, at gene level, of utterly elaborated biological networks. Studying and understanding such models of gene communication might enable researchers to rightly address costly laboratory experiments, e.g. by selecting a …
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Noise and multistability in gene regulatory networks
… each other and bind to DNA to form so-called gene regulatory networks and in this way regulate the level, location and timing of expression of other proteins. Cells implement feedback loops to create a memory of their gene expression states. In this way, every differentiated cell in a …
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Algebraic Methods for Modeling Gene Regulatory Networks
… algebraic methods for modeling and analysis of gene regulatory networks within the discrete modeling context. The first chapter gives a background for discrete models and put in context some of the main research problems that have been pursued in this field for the last fifty years. It also …
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Dynamics of molecular fluctuations in gene regulatory networks
… transcription factors. Proteins are products of genes that regulate the expression of one another, thereby forming large gene regulatory networks that perform specific cellular functions. The complex connectivity between genes of a network could result in various behaviours that are interesting. …
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Gene regulatory networks controlling an epithelial-mesenchymal transition
… fundamental and indispensable to embryonic morphogenesis throughout the animal kingdom. At the onset of gastrulation in the sea urchin embryo, micromere-derived primary mesenchyme cells (PMCs) undergo an EMT process to ingress into the blastocoel, and these cells later become the larval skeleton. …
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Reconstructing gene function and gene regulatory networks in prokaryotes
… a complex environment lies with the network of genetic interactions that process information regarding the state of the cell and its local environment. The object of this study has been to better understand bacterial genetic regulatory networks, which conceptually consist of nodes (the genes) …
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Inference of Gene Regulatory Networks with integration of prior knowledge
Gene regulatory networks (GRNs) are crucial for understanding complex biological processes and disease mechanisms, particularly in cancer. However, GRN inference remains challenging due to the intricate nature of gene interactions and limitations of existing methods. Traditionally, prior knowledge …
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Application of Machine Learning to Mapping and Simulating Gene Regulatory Networks
… in the quantitative and qualitative modeling of gene regulatory networks using high-throughput gene expression data. A semi-parametric Bayesian model based on random forest is developed to infer quantitative aspects of gene regulation relations; a parametric model is developed to predict …
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A Stochastic Framework to Model Extrinsic Noise in Gene Regulatory Networks
… noise. One framework for intrinsic noise in gene regulatory networks was recently proposed within the discrete setting. In contrast, extrinsic perturbations were rarely modeled due to the complex mechanisms that contribute to its emergence. Here a discrete framework to model extrinsic noise …
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CoryneRegNet : a reference database and analysis platform for corynebacterial gene regulatory networks
… factors (the key players in the regulation of gene expression) and on transcriptional regulatory interactions of microorganisms deduced from literature-derived knowledge, computer predictions and global DNA microarray hybridization experiments, has opened the way for the genome-wide analysis of …
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Modeling of gene regulatory networks controlling cell-fate decisions in Bacillus subtilis
… bacterial cells can activate distinct gene-expression programs and differentiate into mutually exclusive cell types. This process is called cell-fate decision. Bacillus subtilis is a well-studied model system for investigating bacterial cell-fate decisions. In Bacillus subtilis, a …
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DeTangle: A Framework for Interactive Prediction and Visualization of Gene Regulatory Networks
… of biological data, computational prediction of gene regulatory networks (GRNs) from gene expression data has become more feasible. Although incorporating other prior knowledge (PK), along with gene expression, greatly improves prediction accuracy, the accuracy remains low. PK in GRN inference …
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Nicotine Alters Gene Regulatory Networks in Dopaminergic Neurons in the Ventral Tegmental Area
… and psychoactive component of tobacco, modulates gene expression in many brain regions implicated in the reward pathway. Dopaminergic (DA) neurons originating from the ventral tegmental area (VTA) of the brain are activated by nicotine and form the natural reward pathway that is known to …
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Synthesising executable gene regulatory networks in haematopoiesis from single-cell gene expression data
… in biology is to understand the complex gene regulatory networks which control tissue development in the mammalian embryo, and maintain homoeostasis in the adult. The cell fate decisions underlying these processes are ultimately made at the level of individual cells. Recent experimental …
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Algorithms for modeling and simulation of biological systems; applications to gene regulatory networks
… level. The reverse-engineering of biochemical networks from experimental data has become a central focus in systems biology. A variety of methods have been proposed for the study and identification of the system's structure and/or dynamics. The objective of this dissertation is to introduce and …
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