Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"gene regulatory network (GRN)"”.
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Gene network understanding and analysis
Gene regulatory network (GRN) is a collection of regulators that interact with each other in the cell to govern the gene expression levels of mRNA and proteins. These regulators can either be DNA, RNA, protein and their complex. Transcriptional gene regulation is an important mechanisms in which an …
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Supervised Inference of Gene Regulatory Networks
A gene regulatory network (GRN) records the interactions among transcription factors and their target genes. GRNs are useful to study how transcription factors (TFs) control gene expression as cells transition between states during differentiation and development. Scientists usually construct GRNs …
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Gut Patterning In Development And Evolution: A Comparative Differential Transcriptomics Approach
… a common kit of transcription factors and cis-regulatory elements that compose the Gene Regulatory Network (GRN) essential for the development of the body plan. Modifications within the elements of the GRN determine the evolution of animal forms. In this study, the GRN for embryonic gut …
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THE HOST-PATHOGEN INTERACTOME AND REGULATORY NETWORKS OF ASPERGILLUS FLAVUS PATHOGENESSIS OF ZEA MAYS: RESISTANCE IN MAIZE TO ASPERGILLUS EAR ROT AND TO AFLATOXIN ACCUMULATION
… (PiZeaM), 2) the development of co-expression networks for Z. mays and A. flavus from RNA-seq data, and 3) the development of causal inference networks depicting interactions between the host and the pathogen. PiZeaM is the genome-wide roadmap of protein-protein interactions that occur within …
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A novel statistical signal processing approach for analysing high volatile expression profiles.
… new advanced statistical methods for analysing gene expression profiles to consequently enhance our understanding of the spatial gradients of the proteins produced by genes in a gene regulatory network (GRN). To that end, this research has three main contributions. In this thesis, the …
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Deciphering the regulatory code driving neural crest evolution and development
… crest. Comparisons to the modern neural crest gene regulatory network (GRN) such as that of the chicken can elucidate essential conserved regions of the GRN. Previous studies in P. marinus revealed a neural crest-specific enhancer for the neural crest specification gene, SoxE1, which showed …
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Gene regulatory networks controlling an epithelial-mesenchymal transition
… fundamental and indispensable to embryonic morphogenesis throughout the animal kingdom. At the onset of gastrulation in the sea urchin embryo, micromere-derived primary mesenchyme cells (PMCs) undergo an EMT process to ingress into the blastocoel, and these cells later become the larval skeleton. …
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Gene regulatory network modelling with evolutionary algorithms -an integrative approach
Building models for gene regulation has been an important aim of Systems Biology over the past years, driven by the large amount of gene expression data that has become available. Models represent regulatory interactions between genes and transcription factors and can provide better understanding …
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Big data analytics in computational biology and bioinformatics
… operations, namely pattern discovery and network inference. The dissertation starts by focusing on biological pattern discovery at a genomic scale. Research reveals that the secondary structure in non-coding RNA (ncRNA) is more conserved during evolution than its primary nucleotide …
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High-throughput phenotyping and physiological genetics of stomatal patterning and water use efficiency in maize
… patterns for putative stomatal regulating genes in maize were found to be qualitatively conserved. Comparisons were also made between a maize stomataless mutant designated as “abnormal stomates” (abs1) and non-mutant plants. This revealed that the gene regulatory network (GRN) of abs1 was …
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Genetic Regulation of Müllerian Duct Regression
… to <em>Amh</em> and <em>Amhr2</em>, several genes have been identified to be essential for proper MD regression.</p> <p>Based upon previous studies in the field, we have described a gene regulatory network (GRN) for MD regression. Further analysis of our GRN for MD regression illuminated an …
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A Systems Level Analysis of the Transcription Factor FoxN2/3 and FGF Signal Transduction in Sea Urchin Larval Skeleton Development and Body Axis Formation
… of a cell is accomplished by changing its gene expression profiles. These processes require temporally and spatially regulated transcription factors (TFs), to induce the genes that are necessary to a specific cell type. In each cell a set of TFs interact with each other or activate their …
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Integrative analysis of transcriptional regulatory programs in mammalian systems
Gene regulatory network (GRN) is the most central known information processing program of life. To understand its importance and complexity, it is sufficient to note that all the cells in our body contain the same genetic code yet carry out functions ranging from energy storage to immune response. …
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Gene Regulatory Networks at Single-Cell Resolution: an approach to exploring the impact of genomic regulation on cellular heterogeneity
… data provides a great opportunity to infer gene regulatory associations in different tissues, cell types and cells. However, there are many challenges still to be overcome. In this thesis, I discuss why this opportunity is fascinating but challenging from a computational point of view, and I …
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The role of criticality of gene regulatory networks on emergent properties of biological systems
<p>The relationship between criticality of gene regulatory networks (GRNs) and dynamics of GRNs at a single cell level has been vigorously studied. However, the relationship between the criticality of GRNs and properties of multicellular organisms at a higher level has not been fully explored. Here …