Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 104 for “"gene regulatory network"”.
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Towards causality in gene regulatory network inference
… the coordination of biomolecules that underlies gene regulation is key to gaining mechanistic insights into cellular functions, phenotypes, and diseases. Advances in single-cell technologies promise to unveil mechanisms of gene regulation at unprecedented resolution by enabling measurements of …
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Unsupervised gene regulatory network inference on microarray data
Obtaining gene regulatory networks (GRNs) from expression data is a challenging and crucial task. Many computational methods and algorithms have been developed to infer gene networks for gene expression data, which are usually obtained from microarray experiments. A gene network is a method to …
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In silico bacterial gene regulatory network reconstruction from sequence
… particularly notorious example is in the area of gene regulatory networks. A molecular study of gene regulation proceeds one protein at a time, requiring bench scientists months of work purifying transcription factors and performing DNA footprinting studies. Massive scale options like ChIP-Seq and …
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Gene regulatory network modelling with evolutionary algorithms -an integrative approach
Building models for gene regulation has been an important aim of Systems Biology over the past years, driven by the large amount of gene expression data that has become available. Models represent regulatory interactions between genes and transcription factors and can provide better understanding …
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Characterisation of the gene regulatory network for posterior segmentation in Parasteatoda tepidariorum
… of components and the architecture of the gene regulatory network that controls the formation of the segment addition zone (SAZ) and posterior segments in the spider Parasteatoda tepidariorum. Analysis of the formation and function of the SAZ among arthropods suggests that Wnt and …
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A dynamic transcriptome technique for transcriptional profiling and gene regulatory network involving the helicase antigen (HAGE)
… drugs. Therefore, it is possible signalling networks could be influenced by as yet unknown molecules or known mediators with function that have not yet been described. As a result of this, work must continue to improve knowledge yet further to allow the design of novel therapies to aid in the …
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Integrating biclustering techniques with de novo gene regulatory network discovery using RNA-seq from skeletal tissues
… of bone and cartilage tissue by determining genes that are expressed and regulated for stem cells to differentiate into skeletal tissues. It would also contribute to the classification of differences in normal skeletogenesis and degenerative conditions involving these tissues. The three …
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Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer
… mutations over others, creating a dynamic heterogeneous system made up of different cell populations, called sub-clones. This heterogeneity poses a challenge for treatment, as this variety serves to ensure there is almost always a portion of the cells which are resistant to any one targeted …
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Unraveling the neurogenin/ngn-1 gene regulatory network of C. elegans using classical genetics and comparative transcriptomics
… survival and function. Defects in neurogenesis have been linked to neurodevelopmental disorders such as schizophrenia and autism spectrum disorders. Understanding the gene regulatory networks that orchestrate neural development, specifically cascades of proneural transcription factors, …
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Multi-target Prediction Methods for Bioinformatics: Approaches for Protein Function Prediction and Candidate Discovery for Gene Regulatory Network Expansion
… a paradigm shift since the advent of next generation sequencing technologies. The retrieved data largely exceeds the capability of biologists to investigate all possibilities in the laboratories, hence predictive tools able to guide the research are now a fundamental component of their …
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Investigating the evolution of diversity and complexity of Prokaryotic gene regulatory networks using in silico models
… origins of diversity and many complex gene regulatory network features, such as global regulation. Using novel in silico models the evolutionary origins of complex features, heterogeneity and the role of stochastic molecular processes in gene regulatory network evolution are …
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Gene regulatory networks controlling an epithelial-mesenchymal transition
… fundamental and indispensable to embryonic morphogenesis throughout the animal kingdom. At the onset of gastrulation in the sea urchin embryo, micromere-derived primary mesenchyme cells (PMCs) undergo an EMT process to ingress into the blastocoel, and these cells later become the larval skeleton. …
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Systems analysis of Crassulacean acid metabolism (CAM) physiology and molecular biology
The main theme of this thesis was to explore the regulatory landscape of CAM using systems biology approaches. The scope of the regulatory landscape was drawn around the mesophyll metabolism of the dicotyledonous obligate CAM genus, *Kalanchoe*, even though the computational frameworks that had …
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Causal Representation Learning for Predicting Genetic Perturbation Effects on Single Cells
… have significantly deepened our understanding of gene regulation in cells. Among these, Perturb-seq has emerged as a powerful technique, enabling high-resolution profiling of transcriptomic responses to genetic perturbations at the single-cell level. Such insights have profound implications for …
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The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
… function as well as promote peripheral nerve regeneration. The present thesis investigates the contribution of SC mitochondrial deficits to disease progression in peripheral neuropathies as well as the gene regulatory network that drives the SC regenerative response after injury and in disease …
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The genetic mechanisms that coordinate the development and morphological divergence of Drosophila genital structures
… these structures are known to some extent, the genetic differences causing phenotypic divergence are not well understood. Drosophila simulans and D. mauritiana exhibit striking morphological differences in the size, shape, and bristle composition of the male periphallic genitalia, despite only …
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Flavonoid diversification in Hibiscus and its impact on petal pattern evolution
… size and colour. This thesis investigates the genetic basis of bullseye patterning and flavonoid pathway diversification across the complex, linking molecular changes to pigment diversity. Flavonoid biosynthesis is regulated by MBW complexes comprising MYB (myeloblastosis) and bHLH (basic …
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Evolution and statistics of biological regulatory networks
… thesis, I study the process of evolution of the gene regulatory network in Escherichia coli. First, I characterize the portion of the network that has been documented, and then I simulate growth of the network. In this study, I assume that the network evolves by gene duplication and divergence. …
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Mechanistic Dissection of Tcf7l1-Dependent Enhancer Decommissioning During Exit from Naïve Pluripotency
… the simultaneous dissolution of the naïve gene regulatory network as well as a redirection of transcriptional response to Wnt/β-catenin signaling. Here, we show that Tcf7l1 functions as a linchpin factor that connects the two outcomes via effects at Tcf7l1-bound cis-regulatory elements in …
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