Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 653 for “"gene regulation"”.
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Combinatorial gene regulation by transcription factors
Combinatorial gene regulation is encoded in enhancers and promoters in the form of binding sites for transcription factors (TFs), which collaboratively recruit the transcriptional machinery and drive gene expression. Using high-throughput and quantitative technologies developed by our lab and …
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Akirin-Mediated Gene Regulation During Cardiac Development
… locus to maintain optimal myogenic gene expression levels. Therefore, Akirin represents a class of novel secondary cofactors that work with transcription machinery to link transcription factor output with chromatin remodeling machinery to facilitate gene expression. Previous work …
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Stochastic modelling of gene regulation with microRNAs
… studies of microRNAs, a novel class of gene regulators, discovered relatively recently, is a rapidly growing field. In particular, researchers are focusing on identifying the targets of microRNAs and the roles of microRNAs in post-transcriptional gene regulation; the work presented in …
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Evolution of Gene Regulation in Papio Baboons
<p>Changes in gene regulation are thought to play an important role in primate evolution and divergence. In support of this hypothesis, comparative evidence clearly demonstrate that gene expression patterns differ between closely related species and tend to evolve under selective constraint. …
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Statistical mechanical modeling of eukaryotic gene regulation
Gene expression patterns are regulated by gene regulatory networks. Central to transcriptional regulation of gene expression is the regulation of the quantities of transcription factors (TFs) bound to genomic regulatory sequences. This thesis work is built on statistical mechanics to study the …
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Sequence-driven gene regulation across cellular contexts
Gene expression is a highly coordinated process that depends on the interplay of the DNA and transcription factors that recognise subsequences of the DNA. Transcription factors can induce chromatin accessibility and recruit co-factor proteins, leading to the indirect recruitment of RNA polymerase …
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Mammalian gene regulation through the 3' UTR
… RNAs that function as post-transcriptional gene regulators in animals and plants. They typically interact with target mRNAs through base-pairing predominantly between bases 2-8 (the 'seed' region) at the 50 end of the miRNA and complementary sites in the target 30 UTR ('seed matches'). These …
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Resource competition in CRISPR-mediated gene regulation
CRISPR-mediated gene regulation is known for its ability to control multiple targets simultaneously due to its modular nature: the same dCas9 effector can target different genes simply by changing the associated gRNA. However, multiplexing requires the sharing of limited amounts of dCas9 protein …
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Novel mechanism in astrocyte gene regulation and function
… novel mechanistic findings in astrocyte specific gene regulation and function by the NFI-X transcription factor which can be further extrapolated to astrocyte differentiation and glial tumor invasion. First, we cloned and analyzed human NFI-X3, a novel splice variant of the nfix gene, which …
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Gene Regulation of Tartrate Metabolism in Salmonella typhimurium
… to understand how Salmonella coordinates its gene expression of carbon and energy sources as it experiences transient nutrient niches to facilitate a branched TCA cycle during early events in infection versus at later time points when an oxidative central metabolism is supported. Specifically, …
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Utilising Single-Cell Technology to Investigate Gene Regulation
… have enabled the accurate quantification of gene expression on a cell-by-cell basis. By capturing the transcriptome of thousands of single cells within complex tissues, ranging from organoids to tumoroids, researchers can map individual gene expression profiles that correspond to distinct …
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Hypoxic gene regulation and oncogenic pathways in neuroblastoma
… patients show remarkable clinical heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates to …
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Distributed Delay Improves the Dynamics of Gene Regulation
Gene Regulatory Networks (GRNs) are the principal decision-making apparatuses of cells. GRNs play a critical role in a diverse array of biological processes; cell-fate determination in embryonic development, the induction of labor at the end of pregnancy, maintenance of circadian rhythms, the onset …
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Gene Regulation Through Artificially Induced DNA Conformational Changes
… has been shown to play an important role in the regulation of gene expression. A consequence of this finding is that agents that alter the conformation of DNA should also affect the regulation of gene expression. To explore this, we used tethered-triple helix oligonucleotides (TFO) to bend DNA. …
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Analysis of combinatorial gene regulation with thermodynamic models
… of TFs bound, the expression level of a target gene is usually determined by the combinatorial control of a number of TFs. The interactions among regulatory proteins and their regulatory sequences collectively form a regulatory network. A major challenge in the study of gene regulation is to …
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DNA Secondary Structure in Human Disease and Gene Regulation
… diseases, but the extent of their formation and regulation on a genome-wide level is still not fully understood. The goal of this work is to further explore the role of DNA secondary structure formation in human disease, and to characterize sites of predicted highly stable DNA secondary structure …
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Systems Biology Approaches to Probe Gene Regulation In Bacteria
… the host are not the product of isolated genes, but instead emerge from the concerted operation of regulatory networks. Therefore, identifying components and the systemic behavior of networks is necessary to a better understanding of gene regulation and pathogenesis. To this end, I have …
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In silico approaches to investigating mechanisms of gene regulation
… the precise spatial and temporal expression of genes is critical to our understanding of gene regulatory networks. Connecting transcription factors to the cis-regulatory elements that they bind and regulate remains a challenging problem in computational biology. The rapid accumulation of whole …
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Helicobacter pylori gene regulation by virulence region located sRNAs
… adenocarcinoma. Helicobacter pylori strains are genetically variable, and some contain a DNA region called the cytotoxin associated gene pathogenicity island (cagPAI) that encodes virulence factors. Gastrointestinal disease associated with H. pylori are more likely to occur in infections with …
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