Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"gene recombination"”.
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Transcription, Editing, and Switching of Antibody Genes
… molecules are assembled from V, D, and J gene segments through a process known as V(D)J recombination. Because of its stochastic nature, V(D)J recombination is expected to create self-reactive specificities. In targeted animals carrying autoantibodies, these specificities were shown to be …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR IN RETROGRADE TRANSPORT ALONG MOTORNEURON AXONS
… diseases (NMDs) are characterized by the degeneration of motorneurons and/or associated skeletal muscles, and reduced BDNF is implicated in NMDs. Using Cre-Lox gene recombination technology our lab generated transgenic mice in which the BDNF gene was knocked out of skeletal muscle. We …
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Characterisation of the lipooligosaccharide biosynthesis gene cluster in campylobacter species
The extensive genetic variation in the lipooligosaccharide (LOS) core biosynthesis gene cluster, a majority of which occurs in the LOS outer core biosynthesis gene content present between lgtF and waaV, have led to the development of a classification system; with 8 classes (I-VIII) for …
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Developing Novel Models and Therapeutics for ZFTA-RELA Ependymoma
… of chromosome 11q that results in a gene translocation between the Zinc Finger Translocation Associated (ZFTA) gene and V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A (RELA), the principal effector of NF-KB signalling. ZFTA-RELA fusion ependymomas are recognised by the …
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Spatial organisation of the immunoglobulin heavy chain locus and inter-chromosomal gene networks driving B cell development
… Igl) loci. The mouse Igh is a large (~3Mb) multigene locus that contains 195 variable (V), 10 diversity (D) and 4 joining (J) genes that undergo developmentally regulated V(D)J recombination to produce the variable region of the antibody. Gene expression depends on spatial organisation of …
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Tracking the In Vivo Dynamics of Antigenic Variation in the African Trypanosome
… host, using an extensive repertoire of dedicated genes. Although this process, referred to as antigenic variation, is the major mechanism of pathogenesis for T. brucei, the dynamics of VSG expression in T. brucei during an infection are poorly understood. In this thesis, I describe the development …
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Investigating R gene evolution by meiotic recombination using synthetic gene clusters in Arabidopsis
Plant gene families organized as linked clusters are capable of evolving by a process of unequal crossing-over. This results in the formation of chimeric genes that may impart a novel function. However, the frequency and functional consequences of these unequal cross-over events are poorly …