Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"gene protein"”.
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Characterization of an alkalophilic Bacillus brevis isolate with respect to its endo-(1,3-1,4)-β-glucanase gene, protein hyperproduction and the degS-degU operon
… of extracellular enzyme producing strains. A gene coding for an endo(1,3- 1,4 )-.8-glucanase (or lichenase) was cloned from B. brevis Alk 36 and expressed in Escherichia coli. The nucleotide sequence of this gene was determined and found to encode a protein of 252 amino acid residues. The …
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The role of MMP10 in non-small cell Lung cancer, and pharmacological evaluation of its potential as a target for therapeutic intervention. Investigation of the role of MMP10 in the tumour microenvironment of non-small cell lung cancer using gene, protein and mass spectrometry approaches to determine MMP10’s potential in drug development strategies
… are required. Among the matrix metalloproteinases (MMPs) that are essential for tumour development, MMP10 is a potential candidate as a therapeutic target based on its expression and contribution to NSCLC development. This research aims to explore the expression and functions of MMP10 …
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Using network clustering to predict copy number variations associated with health disparities
… number variations (CNVs) are one form of human genetic variations that have been linked with complex diseases and often occur at different frequencies among African Americans and Caucasian populations. In this study, we aimed to investigate whether CNVs with differential population frequencies …
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Investigations into the viral molecular determinants of lethality of Punta Toro virus (Bunyaviridae, phlebovirus) in the Syrian hamster.
… dissertation addresses questions regarding viral genetics and their affect on virulence in the hamster model of Phlebovirus pathogenesis. This study reports that PTV strains isolated west of the Panama Canal are not lethal in hamsters and phylogenetic analysis of the coding sequences reveals the …
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Collective analog bioelectronic computation
… integrated-circuit models of protein-protein and gene-protein networks inside a cell. Due to a natural mapping between the Poisson statistics of molecular flows in a chemical reaction and Poisson statistics of electronic current flow in a transistor, stochastic effects are …
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Characterization and site-directed mutagenesis of NifU from Azotobacter vinelandii
In order to elucidate the function of the nifU gene product in nitrogenase maturation in Azotobacter vinelandii. the gene product has been hyperexpressed in Escherichia coli and characterized by various biophysical techniques. Following the initial characterization, site-directed mutagenesis of …
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Biological Circuit Design via BioCAD Tools
… and Synthetic Biology. However, BioCAD is a general purpose tool and can be seen as well as a black box able to receive in input a generic model and analyze its components and submodules, estimate its parameters, or optimize specific functions. BioCAD implements novel and state-of-the-art …
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Mathematical modeling approaches for dynamical analysis of protein regulatory networks with applications to the budding yeast cell cycle and the circadian rhythm in cyanobacteria
… a tool to study regulatory interactions within gene-protein networks. From the modeler's perspective, two challenges arise in the process of building a mathematical model. First, the same regulatory network can be translated into different types of models at different levels of detail, and the …
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Examining the Acute and Chronic Effects of Sepsis on the Circadian Clock in the Mouse
… were also found in post-septic SCN clock gene protein product expression. LPS induced sepsis caused attenuations in SCN functional activation in response to both photic and immune stimulation, as well as alterations in circadian resetting in response to phase resetting immune stimuli. …
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Identification of a mitogen-activated protein kinase, p56, which mediates the self-incompatibility response in Papaver rhoeas L.
… and thus avoid inbreeding. It is a genetically controlled mechanism that encodes a highly specific recognition system that inhibits the growth of incompatible pollen, whereas compatible pollen from an unrelated plant of the same species is able to grow and effect fertilization. In …
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Molecular Analysis of Oomycete Pathogens to Identify and Translate Novel Resistance Mechanisms to Crops
… potential new and durable resistance (R) genes against P. sojae in soybean germplasm. We developed a system to screen soybean germplasm for genes that recognize core Phytophthora sojae RXLR effectors that are conserved within the pathogen species and essential for virulence. R genes that …
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Effect of aging on metabolic status and hormone responsiveness in the ovary
There were significant effects of mares' ages on gene expression in granolosa cells. Most of the effects we noted were on the expression of AMPK subunits, italics indicating genes rather than gene protein products, although there were significant effects of animal age on GLUT4 and IGF-1R expression …
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Model-Based Genomic/Proteomic Signal Processing in Cancer Diagnosis and Prediction
… years, high throughput measurement technologies (gene microarray, protein mass spectrum) have made it possible to simultaneously monitor the expression of thousands of genes or proteins. A topic of great interest is to study the difference of gene/protein expressions between normal and cancer …
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Identify Signature Genes/Pathways to Characterize Alzheimer's Disease Subtypes Based on Uncoupled Tauopathies and Cognitive Decline
… dementia usually found in elderlies, with heterogeneous clinical phenotypes and possible underlying mechanisms. Widely spread tauopathy is one of the pathological change hallmarks in AD brains, in which microtube protein tau forms scar-like neurofibrillary tangles that kill neurons. However, …
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Examination of Molecular Mechanisms Underlying Developmental and Adult Learning-Associated Plasticity in the Rat Brain
… in this thesis examined the expression of two proteins, a transcription factor, Fos, which influences cellular change at the genomic level, and a cytoskeletal protein, Flatmap 1, involved in dynamic change of the cell at such localized areas as the cell soma or processes. These proteins were of …
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The effects of complex I deficiency on neurogenesis and white matter development in a mouse model of Leigh Syndrome (LS)
… of neural stem/progenitor cells (NSCs), which generate the majority of the brain cells during the embryonic and early postnatal periods. However, the in vivo consequences of sustained mitochondrial dysfunction during early neurogenesis remain poorly characterized. We leveraged the NDUFS4 …
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Host Immune-Microbial Interactions in Inflammatory States
… technologies and approaches that would span the gene, protein, and metabolite levels. To assess the functional component of the HD immune response to vaccine stimulation, anti-spike IgG and neutralizing antibody titers were measured at time points before and after vaccination and revealed …
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Chronic Hypoxia Induces Epigenetic Modifications in the Fetal Rat Heart
… that events in utero can significantly alter gene expression patterns in heart tissue leading to increase susceptibility to ischemia reperfusion injury in adulthood. The focus of this project was to elucidate the role of chronic hypoxia in the programming of the cardio-protective gene, Protein …
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Fast simulation of stochastic biochemical reaction networks on cytomorphic chips
… pensive Gillespie algorithms and random-number generation for accurate simulations; and, they routinely operate with nonlinear statics and dynamics. Hence, such simulations are extremely computationally intensive and have remained an important bottleneck in computational biology over decades. By …
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Astrocyte and vascular changes contribute to Alzheimer's disease
… (AD), the most prevalent age-related neurodegenerative disorder, is defined by the pathological accumulation of amyloid-β (Aβ) peptides, neurofibrillary tangles (NFTs), neuronal loss, and the activation of astrocytes and microglia. One of the early indicators of AD is a global reduction in …
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